An index of prenatal steroid exposure predicts adult face perception skills

Face perception skills are fundamental to social cognition, yet they vary markedly across individuals. This diversity has stimulated controversy over the relative contributions of genetic factors, prenatal environment, and postnatal experience to face perception. Recent twin studies have found that face perception is heritable, highlighting the potential for substantial prenatal determination of these skills. In contrast, previous work on potential influences of the prenatal hormonal environment on social cognition have found no association between 2D:4D, a marker for prenatal androgen exposure, and processing of facial emotional expressions, apparently precluding a major role for prenatal hormones in governing face perception. We propose that substantial predictive relationships between 2D:4D and face perception may have been masked in previous work because the task employed required both face perception and processing of others?? emotions, the latter component being greatly influenced by circulating hormones in adults. To assess prenatal hormone influences on face perception without requiring emotion processing, we related 2D:4D to the face inversion effect (FIE), a measure of the recruitment of specialist face processes to visual perception. The magnitude of the resulting predictive relationship (r = .52) compared surprisingly well with that found between identical twins?? face perception (rs = .27?C.61), suggesting that mechanisms of 2D:4D may account for a substantial proportion of perinatal influences on face processing. Furthermore, we employed 2D:4D as a common scale to map individual differences in the FIE onto prenatal testosterone:estrogen ratios, assayed by Lutchmaya, Baron-Cohen, Raggatt, Knickmeyer, and Manning (Early Human Development 77:23?C28, 2004). The substantial overlap between the two data sets further implicates prenatal steroids in adult face perception skills.     

Is the Continuity of Externalizing Psychopathology the Same in Adolescents and Middle–Aged Adults? A Test of the Externalizing Spectrum’s Developmental Coherence

Externalizing psychopathology (EXT) is a framework for understanding diagnostic comorbidity and etiology of antisocial and substance-use behaviors. EXT indicates continuity in adulthood but the structure of adolescent EXT is less clear. This report examines whether adolescent EXT is trait-like, as has been found with adults, or categorical. We use tests of measurement invariance to determine how diagnostic indicators of EXT differ in adolescents compared to adults. The EXT measures employed were DSM-IIIR diagnoses of adult antisocial behavior, conduct disorder, and alcohol, marijuana, and drug dependence. Latent trait, latent class, and hybrid models were fit to two separate data sets: 2,769 seventeen-year-old adolescents and 2,619 adults from the Minnesota Twin Family Study. The best model in both samples was a single-trait LT model. Parameters from the adolescent and adult models were equivalent for all disorders except alcohol dependence. It appears that EXT in adolescence can be accurately represented by a single-trait model, and the measurement properties of EXT are similar during these time periods with the exception of alcohol dependence.     

Development and validation of a revised measure of codependency

This study assessed the factor structure, internal consistency, and concurrent validity of a revised instrument, the Composite Codependency Scale (CCS), a 19‐item measure designed to assess codependent traits. Exploratory factor analysis of the CCS, using data from 301 adults from the general population and 49 attending members of Codependents Anonymous (CoDA), yielded three factors: self‐sacrifice, interpersonal control, and emotional suppression. The scale and its subscales exhibited good internal consistency. Consistent with the tenets of the codependency model, higher codependency scores were significantly associated with higher levels of depression, anxiety, stress, and familial dysfunction and lower levels of narcissistic tendencies, self‐esteem, and emotional expressivity. Furthermore, the revised measure effectively discriminated members of CoDA from those in the general population.     

Revisiting the suitability of antisaccade performance as an endophenotype in schizophrenia

Poor performance on the antisaccade task has been proposed as a candidate endophenotype in schizophrenia. Caveats to this proposal, however, include inconsistent findings in first-degree relatives of individuals with schizophrenia, and substantial heterogeneity in individuals with the disorder. In this study, we examined antisaccade performance in patients and relatives, and sought to establish whether antisaccade measures could differentiate between two patients clusters identified in the Western Australian Family Study of Schizophrenia with either pervasive cognitive deficits (CD) or cognitively spared (CS). Ninety-three patients (CD = 47, CS = 46), 99 relatives and 62 healthy controls carried out a standard antisaccade task. Results showed: (i) significantly greater error rate, and prolonged latencies to correct responses and self-correction saccades in patients compared with controls; (ii) high error rates in relatives of poorly performing patients; (iii) longer latencies of self-correction saccades in relatives compared to controls; and (iv) higher error rate and longer latencies of self-correction saccades in the CD subgroup compared with CS. Unaffected relatives as a group were unimpaired in error rate as compared to healthy controls. These findings suggest that the antisaccade error rate and latency of self-correction saccades are useful measures in specific applications of genetic research in schizophrenia, without fully meeting endophenotype co-familiality requirements.     

The Impact of Right Temporal Lobe Epilepsy On Nonverbal Memory: Meta-regression of Stimulus- and Task-related Moderators

Neuropsychology Review - Nonverbal memory tests have great potential value for detecting the impact of lateralized pathology and predicting the risk of memory loss following right temporal lobe...     

Recognition by association: Within‐ and cross‐modality associative priming with faces and voices

Recent literature has raised the suggestion that voice recognition runs in parallel to face recognition. As a result, a prediction can be made that voices should prime faces and faces should prime voices. A traditional associative priming paradigm was used in two studies to explore within‐modality priming and cross‐modality priming. In the within‐modality condition where both prime and target were faces, analysis indicated the expected associative priming effect: The familiarity decision to the second target celebrity was made more quickly if preceded by a semantically related prime celebrity, than if preceded by an unrelated prime celebrity. In the cross‐modality condition, where a voice prime preceded a face target, analysis indicated no associative priming when a 3‐s stimulus onset asynchrony (SOA) was used. However, when a relatively longer SOA was used, providing time for robust recognition of the prime, significant cross‐modality priming emerged. These data are explored within the context of a unified account of face and voice recognition, which recognizes weaker voice processing than face processing.     

Eveningness and Seasonality are Associated with the Bipolar Disorder Vulnerability Trait

Trait theories of vulnerability to bipolar disorder (BD) are increasingly common in the literature, yet poorly understood. The aim of the current study was to complement existing knowledge of trait theories by investigating two biological rhythm features often associated with BD – eveningness and seasonality – in a sample assessed as vulnerable to the disorder. Two hundred and thirteen participants completed an online survey consisting of the General Behavior Inventory, Seasonal Pattern Assessment Questionnaire, and Morningness-Eveningness Questionnaire. Hierarchical regressions controlling for sex and age showed that greater levels of seasonality and a tendency towards an eveningness chronotype were weak, but significant predictors of the BD vulnerability trait. When the traits of vulnerability to depression and mania were investigated separately, seasonality and eveningness were significant predictors of the former, but only seasonality was a significant predictor of the latter. The Autumn/Winter pattern of seasonality was a weak predictor of trait vulnerability to mania but not depression. The current findings advance understanding of the BD vulnerability trait, and may have consequences for the behavioural management of those who are considered to be ‘at risk’ of the disorder.     

The illusion of control: Sequential dependencies underlie contingent attentional capture

The degree to which humans have top-down control over which information they process remains a central debate within the attention literature. Most of the evidence supporting the top-down control of visuospatial attention has come from cueing paradigms in which target stimuli are preceded by cues that are similar or dissimilar from the target. These studies find that the cues similar to targets capture attention, but dissimilar cues do not, suggesting the top-down control of attention. Here, we used a modified cueing paradigm to investigate an alternative possibility that the cue type differences are due to sequential dependency effects occurring between cue and target processing rather than the top-down control of attention. When individuals searched for color targets, we replicated contingent capture effects in RTs, which are susceptible to sequential dependencies, but memory performance was always best at the cued locations, regardless of the cue’s identity. When individuals searched for onset targets, we observed contingent capture in both tasks. These results demonstrate the utility of the memory probe paradigm and suggest an asymmetry between how strongly onsets and color defined cues capture attention.