Cocaine-induced brainstem seizures and behavior

A variety of abnormal sensory/motor behaviors associated with electrical discharges recorded from the bilateral brainstem were induced in adult WKY rats by mechanical (electrode implants) and DC electrical current stimulations and by acute and chronic administration of cocaine. The electrode implant implicated one side or the other of the reticular system of the brainstem but subjects were not incapacitated by the stimulations. Cocaine (40 mg/kg) was injected subcutaneously for an acute experiment and subsequent 20 mg/kg doses twice daily for 3 days in a chronic study. Cocaine generated more abnormal behaviors in the brainstem perturbation group, especially the electrically perturbated subjects. The abnormal behaviors were yawning, retrocollis, hyperactivity, hypersensitivity, “beating drum” behavior, squealing, head bobbing, circling, sniffing, abnormal posturing, and facial twitching. Shifts in the power frequency spectra of the discharge patterns were noted between quiet and pacing behavioral states. Hypersensitivity to various auditory, tactile, and visual stimulation was present and shifts in the brainstem ambient power spectral frequency occurred in response to tactile stimulation. These findings suggest that the brainstem generates and propagates pathological discharges that can be elicited by mechanical and DC electrical perturbation. Cocaine was found to activate the discharge system and thus induce abnormal behaviors that are generated at the discharge site and at distant sites to which the discharge propagates. Cognitive functions may also be involved since dopaminergic and serotonergic cellular elements at the brainstem level are also implicated.     

Explaining the gender difference in depressive symptoms

It was hypothesized that women are more vulnerable to depressive symptoms than men because they are more likely to experience chronic negative circumstances (or strain), to have a low sense of mastery, and to engage in ruminative coping. The hypotheses were tested in a 2-wave study of approximately 1,100 community-based adults who were 25 to 75 years old. Chronic strain, low mastery, and rumination were each more common in women than in men and mediated the gender difference in depressive symptoms. Rumination amplified the effects of mastery and, to some extent, chronic strain on depressive symptoms. In addition, chronic strain and rumination had reciprocal effects on each other over time, and low mastery also contributed to more rumination. Finally, depressive symptoms contributed to more rumination and less mastery over time.     

The Milan method—a preliminary critique*

The elegance of the techniques developed by the Milan group has tended to blind family therapists to the many problems inherent in their approach. A close reading of their work uncovers many ethical and political issues which need to be addressed. This paper is a preliminary attempt to develop a critique of the group's method which recapitulates some of the most alienating aspects of the traditional medical model. It will concentrate solely on a critical reading of Paradox and Counterparadox and will not seek to come to terms with the more recent evolution of the Milan school.     

Binocular detection by normal and stereoblind observers

Binocular forced-choice detection performance was measured in three stereoblind observers and four observers with normal stereopsis. Detection rates of normal observers were greater than expected from probability summation, while those of the stereoblind observers were near or at a level expected from probability. It is concluded that binocular summation is reduced or absent in stereoblind persons.     

Psychophysiological assessment of imagery in obsessive-compulsives: a pilot study

In a within-groups design, four obsessive-compulsive patients imagined four different types of scenes: (1) exposure to feared situations; (2) exposure to feared situations followed by engaging in ritualistic behavior: (3) engaging in ritualistic behavior without provocation; and (4) neutral situations. Each scene type was presented three times with order of presentation randomized. Beat-by-beat heart rate samples were taken during the visualization of each scene and converted to second-by-second heart rate. An examination of second-by-second heart rate for each scene type suggested that scenes involving exposure to feared situations elicited defensive responses (DR), whereas those that did not elicited orienting responses (OR). The implications of these results for compulsive behavior, the fear-reduction model and Sokolov's (1963) OR-DR model, are briefly discussed.     

The reading grade level of common measures in child and adolescent clinical psychology

The purpose of this article is to provide easily accessible readability information for 49 parent- and 35 child- and adolescent-report measures commonly used by clinicians and researchers. There is a great deal of variability in reading ability required across measures. The majority of parent-report measures (65%) required reading ability above the 8th grade level. The average child-/adolescent-report measure required reading ability above the 6th grade level. Given the potential contribution of readability to a measure's reliability, validity, and overall utility, examining and accounting for readability should be a more common practice in test construction and administration.     

Windows into nothingness: terror management, meaninglessness, and negative reactions to modern art

Why do people dislike art that they find meaningless? According to terror management theory, maintaining a basic meaningful view of reality is a key prerequisite for managing concerns about mortality. Therefore, mortality salience should decrease liking for apparently meaningless art, particularly among those predisposed to unambiguous knowledge. Accordingly, mortality salience diminished affection for modern art in Study 1, and this effect was shown in Study 2 to be specific to individuals with a high personal need for structure (PNS). In Studies 3 and 4, mortality salient high-PNS participants disliked modern art unless it was imbued with meaning, either by means of a title or a personal frame of reference induction. Discussion focused on the roles of meaninglessness, PNS, and art in terror management.     

Associative learning of likes and dislikes: Some current controversies and possible ways forward

Evaluative conditioning (EC) is one of the terms that is used to refer to associatively induced changes in liking. Many controversies have arisen in the literature on EC. Do associatively induced changes in liking actually exist? Does EC depend on awareness of the fact that stimuli are associated? Is EC resistant to extinction? Does attention help or hinder EC? As an introduction to this special issue, we will discuss the extent to which the papers that are published in this issue help to resolve some of the controversies that surround EC. We also speculate about possible boundary conditions of EC and attempt to reconcile conflicting results on the functional properties of EC.     

Medical problems,maladaptive behaviors,and the developmentally disabled

Research has shown that aberrant behaviors of people with developmental disabilities have multiple determinants; of these, medical problems and their potential relations to aberrant behaviors, have been, for the most part, not studied. This retrospective study examined the relations of 26 acute medical treatements to the aberrant behaviors of 10 elderly people with developmental disabilities. Results showed that 73.1% of the aberrant behaviors decreased in frequency after medical treatments. The study suggests the importance of acute medical problems and treatments as possible factors in the occurrence of aberrant behaviors in this population.