Fibroblast growth factor-2 alters the nature of extinction

These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not depend on NMDAr activation. Three experiments demonstrated that FGF2 prevents the switch from NMDAr-dependent to NMDAr-independent reacquisition and re-extinction, suggesting that FGF2 may lead to the partial erasure of the original fear memory. These findings add to a growing body of work suggesting that FGF2 may be a novel pharmacological enhancer of exposure therapy for humans with anxiety disorders.     

Configural processing and perceptions of head tilt

Configural processing is important for face recognition, but its role in other types of face processing is unclear. In the present study, participants made judgments of head tilt for faces in which the vertical position of the internal facial region was varied. We found a highly reliable relationship between inner-face position and perceived head tilt. We also found that changes in inner-face position affected the perceived dimensions of an individual unchanged facial feature: compared to control faces, nearly two-thirds of faces in which the features had been moved down were judged to have a longer nose. This finding suggests an early integration of configural and featural processing to create a stable holistic percept of the face. The demonstration of holistic processing at a basic perceptual level (as opposed to during face recognition) is important as it constrains possible models of the relationships between featural and configural processing.     

Longitudinal Analysis of Adolescent NSSI: The Role of Intrapersonal and Interpersonal Factors

Non-suicidal self-injury (NSSI) occurs in approximately 10 % of adolescents. To establish effective prevention and intervention initiatives, it is important to understand onset, maintenance and cessation of NSSI. We explored whether the relationships between interpersonal factors (i.e. attachment, social support) and NSSI were mediated by intrapersonal factors (i.e. emotion regulation, self-esteem, self-efficacy). Participants were 1973 students (1414 female and 559 male) aged between 12 and 18 years (M?=?13.89, SD?=?0.97) recruited from 40 Australian high schools. Participants completed a questionnaire at two time-points with a 12-month interval. At baseline, 8.3 % of adolescents engaged in NSSI, increasing to 11.9 % at follow-up. Family support was most salient in onset, maintenance and cessation of NSSI. Attachment anxiety was related to NSSI onset. Of the intrapersonal variables, self-esteem and self-efficacy were significant in predicting onset of NSSI. Self-esteem, self-efficacy and cognitive reappraisal mediated the relationship between attachment anxiety and NSSI onset. A combination of interpersonal and intrapersonal variables contributes to the onset, maintenance and cessation of NSSI in adolescence. Perceived family support appears to be an important safeguard against NSSI. Strategies targeting family functioning and teaching cognitive reappraisal techniques to adolescents may reduce the number engaging in NSSI.     

Three methods of developing MMPI taxonomies of sexual offenders

In a sample of 261 state hospital sexual offenders, Minnesota Multiphasic Personality Inventory (MMPI) profiles did not differ for offenders with adult victims versus offenders with child victims when offender age was controlled. MMPI 2-point analyses for the whole sample revealed five common codes that were independent of victim maturity. The sample was randomly divided in half and subjected to a cluster-analytic procedure which revealed two MMPI clusters. The first cluster was unelevated, with Scale 4 as its high point. The second cluster had multiple elevations, with Scales 8, 4, 2, and 7 as the highest scales. These clusters were replicated in a cluster analysis of the second half of the sample. However, when the sample was recombined, the two clusters were not externally validated basis on demographic and criminological variables. The results suggest that common psychological variables among sexual offenders may have more discriminative value than victim maturity in developing sexual offender taxonomies.     

Social influence processes affecting adolescent substance use

Social influence is central to models of adolescent substance use. Nonetheless, researchers fail to delineate the various forms of social influence. A framework that distinguishes between active (explicit drug offers) and passive (social modeling and overestimation of friends' use) social pressure was tested. The effect of these processes on alcohol and cigarette use was examined with 526 seventh graders taking part in an alcohol prevention program. Hierarchical regression analyses demonstrated that pretest measures of alcohol use, offers, modeling, and overestimation each accounted for unique variance in posttest alcohol use. Similar results were obtained for cigarette smoking. The general model was not significantly different for boys and girls, or for prior users and prior nonusers, supporting the generalizability of the framework. Implications for intervention programs are discussed.     

Detecting fake-good and fake-bad MMPI-2 profiles

This study examined the extent to which the validity scales of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) could identify subjects who were faking bad or faking good and differentiate between psychiatric patients and normal subjects who were faking bad. Subjects were 106 undergraduate college students and 50 psychiatric patients. Results indicate that the mean profiles and optimal cutoff scores resembled those previously reported for the original MMPI. Accurate identification of persons who were faking bad or faking good was achieved. It was possible to differentiate between the psychiatric patients and normal persons who were faking bad, but different cutoff scores were needed to differentiate between normals taking the test under standard instructions and those instructed to fake bad. Optimal cutoff scores were suggested.     

The Chalcedonian Logic of John Wesley's Christology

This article addresses John Wesley's theology of the person of Jesus Christ. Against those who have discerned either a Monophysite or a Nestorian trajectory, it argues that Wesley's Christology as a whole conforms to a Chalcedonian grammar, displaying certain Alexandrian–Lutheran tendencies in particular. It does so in three stages. First, it examines Wesley's emphasis on Christ's divinity, his ostensible reservations about Christ's humanity, and his view of the hypostatic union in the context of dogmatic christological traditions. Second, it situates his christological emphases within his deistic ideological context. Finally, it briefly illuminates the connection between Wesley's thought on Christ's person and his theology of Christ's work.     

Emergence and Causal Powers

This paper argues that the non-reductive monist need not be concerned about the ‘problem’ of mental causation; one can accept both the irreducibility of mental properties to physical properties and the causal closure of the physical. More precisely, it is argued that instances of mental properties can be causally efficacious, and that there is no special barrier to seeing mental properties whose instances are causally efficacious as being causally relevant to the effects they help to bring about. It is then shown that the causal relevance of mental properties is consistent with there being no downward causation, so the dilemma of ‘epiphenomenalism or reduction’ can be avoided. Non-reductive monism lives on as a viable position in the philosophy of mind.

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