Mounting evidence has established that diet-induced obesity (DIO) is associated with deficits in hippocampus-dependent memory. The bulk of research studies dealing with this topic have utilized rats fed a high-fat diet as an experimental model. To date, there has been a paucity of research studies that have established whether the memory deficits exhibited in DIO rats can be recapitulated in mice. Moreover, the majority of experiments that have evaluated memory performance in rodent models of DIO have utilized memory tests that are essentially aversive in nature (i.e., Morris water maze). The current study sought to fill an empirical void by determining if mice maintained on a high-fat diet exhibit deficits in two non-aversive memory paradigms: novel object recognition (NOR) and object location memory (OLM). Here we report that mice fed a high-fat diet over 23 weeks exhibit intact NOR, albeit a marked impairment in hippocampus-dependent OLM. We also determined the existence of corresponding aberrations in gene expression within the hippocampus of DIO mice. DIO mice exhibited significant reductions in both SIRT1 and PP1 mRNA within the hippocampus. Our data suggest that mice maintained on a high-fat diet present with impaired hippocampus-dependent spatial memory and a corresponding alteration in the expression of genes that have been implicated in memory consolidation. 相似文献
This investigation tested whether social norms and endorsement of humanitarian values interact to influence authoritarians' attitudes toward immigrants. Oyamot, Borgida, and Fisher (2006) found correlational evidence for a model in which: (1) clear social norms for attitudes toward an outgroup (favorable or unfavorable) influence the authoritarianism–attitude relationship in the direction of the norm, and (2) in the absence of clear social norms, endorsement of humanitarian–egalitarian values attenuate the intolerant tendencies of authoritarians. The current investigation tested the model in a survey experiment conducted in a diverse adult sample (N = 388). We measured participants' levels of authoritarian predisposition and endorsement of humanitarian values. Participants were then randomly told that Americans in general had either negative, positive, or mixed opinions about immigrants and immigration (social norm condition), and then asked about their attitude toward immigrants. Consistent with the model, authoritarianism was negatively related to attitudes toward immigrants in the negative norm condition. However, authoritarians' tendency toward intolerance was attenuated when they thought that Americans in general had positive opinions about immigrants. Also as predicted, when societal norms were depicted as mixed, authoritarians' attitudes depended upon endorsement of humanitarian values: humanitarian authoritarians held positive attitudes and non-humanitarian authoritarians held the most negative attitudes toward immigrants. Implications for understanding the effects of authoritarian predispositions in varying social contexts are discussed. 相似文献
This article is the published version of the 2011 H. Paul Douglass Lecture given at the Religious Research Association meeting in Milwaukee, WI. It argues that there has been a step change in activity with regard to the social scientific work on religion in Europe in the last half decade. It sets out the evidence for this claim and the (not always positive) reasons why this had happened. It then examines the implications of this work for the faith communities of modern Europe, arguing that effective cooperation between the religious sector and the researchers who study this is the best antidote for the misconceptions about religion that currently abound in many European societies. 相似文献
How do body representations influence decisions about action? We developed a novel paradigm using the mirror illusion (Holmes, Crozier, & Spence, in Cognitive, Affective, & Behavioral Neuroscience, 4, 193–200, 2004) to examine two ways of evoking body plasticity—extension of body capabilities and visual capture—and its influence on perceived affordances. In two experiments, we manipulated the action capabilities of a seen left hand by lengthening the arm with a rod (Exp. 1) or enlarging the hand with a glove (Exp. 2). The right hand was unaltered physically and was occluded by placement in a mirror box. We induced visual capture through synchronous finger movements of both hands. Right-hand estimates of reaching and of fitting through apertures increased relative to actual capabilities during visual capture, supporting the claim that visual capture can induce the incorporation of an apparent body extension into action decisions. The results suggest that both perceptual and cognitive influences on bodily awareness underlie perceived affordances. 相似文献
The current review evaluates the use of treatment fidelity strategies in evidence-based parent training programs for treating externalizing disorders. We used a broad framework for evaluating treatment fidelity developed by the National Institutes of HealthTreatment Fidelity Workgroup that includes the aspects of treatment design, treatment delivery, training providers, and assessment of participant receipt of treatment and enactment of treatment skills. Sixty-five articles reporting outcome trials of evidence-based parent training programs met inclusion criteria and were coded for treatment fidelity strategies. The mean adherence to fidelity strategies was .73, which was higher than two previous review studies employing this framework in the health literature. Strategies related to treatment design showed the highest mean adherence (.83), whereas training of providers and enactment of treatment skills had the lowest (.58). In light of an increasing emphasis on effectiveness and dissemination trials, the broader treatment fidelity framework as applied in this review focuses needed attention on areas often overlooked in fidelity practices, such as training providers and generalization of treatment skills. We discuss the strengths and limitations of fidelity practices in parent training studies, implications of these findings, and areas for future research. 相似文献
Journal of Child and Family Studies - Drawing on self-determination theory and problem-behavior theory, we tested the relation between parental psychological control and adolescents’... 相似文献
In response to the COVID-19 pandemic, restrictions on economic activities have resulted in a sharp rise of unemployment. The purpose of this research is to explore mental disorders associated with COVID-19 related unemployment using a large, nationally representative dataset, the 2020 COVID-19 Household Pulse Survey. ANOVA with post hoc tests (Tukey HSD) are utilized to reveal the mean difference of mental disorders between various employment status, as well as between reasons of unemployment. Binary logit model is used to investigate the potential effect of different reasons of unemployment on mental disorders. Individuals who were not working during the pandemic due to involuntary reasons had higher probabilities of mental disorders than those who were working and those who voluntarily separated from work. Among respondents who were not working due to COVID-19 related reasons, respondents whose employer went out of business were the most likely to experience mental disorders. Household job uncertainty in the next four weeks positively contributed to mental disorders. Government should consider measures to contain the spread of virous while keeping as many people employed as possible. Government should also consider providing adequate financial and counseling assistance to individuals who are in the greatest need for such support.
The current research tested the concept of institutional agency (IA) and its implications for laypeople's attribution patterns related to economic behaviors and organizational responsibilities. The term “institutional agency” refers to a set of lay theories about whether or not an organization can have personhood and related mental properties, such as wishes, desires, intents, and responsibility. Through three cross‐cultural studies, we found that people do form certain beliefs about IA which are similar to the legal discourse of institutional responsibility. However, there are significant cultural differences in views of IA, and the concept is more mentally salient for Americans than for Chinese. In Study 1, we distinguished institutional from group agency by showing the cultural differences on attributions in the scenario with “individual vs. group agency” and the scenario with “individual vs. institutional agency.” In Study 2, we again demonstrated the stronger salience of IA for Americans than for Chinese by including the individual, group, and institutional agencies together in one scenario. In Study 3, we further demonstrated that the concept of IA is more salient for Americans by presenting three different agents in separate scenarios. The practical implications of these cultural differences for cross‐cultural understanding and the psychological effects of economic globalization are discussed. 相似文献