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131.
It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM). We also demonstrated that the blockade of Ang II receptors AT1, but not AT2, recovers ORM impairment of Mas-deficient mice. Considering that high concentrations of Ang-(1-7) may activate AT1 receptors, nonspecifically, we evaluate the levels of Ang-(1-7) and its main precursors Ang I and Ang II in the hippocampus of Mas-deficient mice. The Ang I and Ang II levels are unaltered in the whole hipocampus of MasKo. However, Ang-(1-7) concentration is increased in the whole hippocampus of MasKo mice, as well as in the CA1 area. Taken together, our findings suggest that the functionality of the Ang-(1-7)/Mas axis is essential for normal ORM processing.  相似文献   
132.
Szalma JL  Teo GW 《Acta psychologica》2012,139(3):471-485
The goal for this study was to test assertions of the dynamic adaptability theory of stress, which proposes two fundamental task dimensions, information rate (temporal properties of a task) and information structure (spatial properties of a task). The theory predicts adaptive stability across stress magnitudes, with progressive and precipitous changes in adaptive response manifesting first as increases in perceived workload and stress and then as performance failure. Information structure was manipulated by varying the number of displays to be monitored (1, 2, 4 or 8 displays). Information rate was manipulated by varying stimulus presentation rate (8, 12, 16, or 20 events/min). A signal detection task was used in which critical signals were pairs of digits that differed by 0 or 1. Performance accuracy declined and workload and stress increased as a function of increased task demand, with a precipitous decline in accuracy at the highest demand levels. However, the form of performance change as well as the pattern of relationships between speed and accuracy and between performance and workload/stress indicates that some aspects of the theory need revision. Implications of the results for the theory and for future research are discussed.  相似文献   
133.
The current research investigated whether mothers of transgender youth experience stigma-by-association. Mturk participants (N = 489) were randomly assigned to read a vignette about a family in which the social identity (transgender, gay/lesbian, cisgender/heterosexual control) and gender (girl, boy) of a child was manipulated, while all other information was held constant. Results revealed stigma targeting mothers as a function of children's social identity (but not gender), such that mothers of transgender girls and boys were viewed substantially more negatively than identical mothers of cisgender/heterosexual youth. Moreover, this stigma was particularly robust among politically conservative participants. In contrast, mothers of gay/lesbian youth did not encounter systematic stigma, though they were sometimes perceived more negatively than mothers of cisgender/heterosexual youth. Results provide novel experimental evidence of stigma-by-association targeting mothers of transgender youth and raise serious concerns about the treatment of parents who seek to affirm their transgender children.  相似文献   
134.
In a time of increasing religious diversity, interfaith political coalitions have become important settings for interreligious interaction, but little research has explored the types of religious expression that are generated therein. Prevailing theories in the sociology of religion indicate that interaction with religious others results in dilution of traditional religious commitments or production of stronger boundaries. But emerging perspectives in cultural sociology shift attention from individual religious commitments to the ways in which settings shape different styles of religious expression. Insights about edge spaces drawn from urban theory suggest that religiously diverse settings can be generative of new types of religious practices. We apply these insights to the study of interfaith activism by drawing on interviews and ethnographic fieldwork with religious advocacy professionals and activists working in interfaith coalitions. Conceptualizing the sites of these interfaith encounters as edge spaces, we analyze variation in the types of religious expression that occur in interfaith settings. We find that both aggregative and integrative practices are produced, but these vary depending on the goals and structure of the setting, as well as participants’ accountability to outside religious gatekeepers.  相似文献   
135.
We tested domestic dogs (N = 16) in a Guesser–Knower task in which they chose between possible locations for hidden food indicated by human informants. In four experiments, the perceptual access of the Guesser and Knower to the hidden food baiting was manipulated. When informants had differing perceptual access to the baiting, dogs preferred the location indicated by the Knower from the start of testing (Experiment 1), even when baiting was done by a third experimenter (Experiments 2–3). However, when there was no difference in perceptual access and both informants either knew or did not know the food location, dogs had no preference between the informants (Experiment 4). Controls ruled out alternative explanations in terms of associative learning, unintentional and olfactory cues. Analysis of individual data showed no significant heterogeneity across dogs, and results were not correlated with age or sex. Dogs’ performances were superior to those of nonhuman primates in previous studies. Although a mentalistic explanation is not required, results add to evidence that dogs have a remarkable sensitivity to cues related to humans’ attentional state, which enables them to respond as if they had a functional theory of mind in the Guesser–Knower task with human informants.  相似文献   
136.
Aims: The purposes of this study were to examine: (1) the content of and reasons for trainee nondisclosure in supervision, and (2) the influence of trainee anxiety and perception of the supervisory working alliance on amount of nondisclosure and willingness to disclose. Method: As the focus of the study was a single supervision session, qualitative and quantitative data were collected from 204 trainees about their most recent supervision session. Results: Within the single supervision session on which they reported, 84.3% of trainees withheld information from their supervisors. Trainees reported an average of 2.68 nondisclosures occurring in the session, with the most common nondisclosure involving a negative supervision experience. Trainee perception of a better supervisory working alliance was related to less nondisclosure and greater overall willingness to disclose in supervision. Higher trainee anxiety was related to greater nondisclosure and lower overall willingness to disclose in supervision. Implications: The implications of the findings for the practice of supervision are discussed and areas for further research are suggested.  相似文献   
137.
This paper considers a seldom-discussed feature of assessment, namely, the significance of the setting of a fee and its connection with the setting in which a fee is agreed. Its importance is illustrated with reference to the three-times-weekly sessions over a period of one year with a single woman in her 30s. It will be seen how, in much the same way as aspects of her earliest history coloured her development from the start, the experience of setting the fee in the first session of treatment influenced subsequent features of the work.

In this case, the charging of a lowered fee will be shown to have affected the nature of the therapeutic relationship and it will be seen how the issue of payment of a fee at all provided a focus from which psychodynamically important material could be developed. It gave opportunity for the testing and working-through of a number of elements, both conscious and unconscious, throughout the first year of treatment. That is, the issue of the fee was found to be grossly over-determined — symptomatic of roots in several quite separate feelings and memories, each of which had to be uncovered before the issue could begin to be resolved.  相似文献   
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Family involvement is recognized as a critical element of service planning for children’s mental health, welfare and education. For the juvenile justice system, however, parents’ roles in this system are complex due to youths’ legal rights, public safety, a process which can legally position parents as plaintiffs, and a historical legacy of blaming parents for youth indiscretions. Three recent national surveys of juvenile justice‐involved parents reveal that the current paradigm elicits feelings of stress, shame and distrust among parents and is likely leading to worse outcomes for youth, families and communities. While research on the impact of family involvement in the justice system is starting to emerge, the field currently has no organizing framework to guide a research agenda, interpret outcomes or translate findings for practitioners. We propose a research framework for family involvement that is informed by a comprehensive review and content analysis of current, published arguments for family involvement in juvenile justice along with a synthesis of family involvement efforts in other child‐serving systems. In this model, family involvement is presented as an ascending, ordinal concept beginning with (1) exclusion, and moving toward climates characterized by (2) information‐giving, (3) information‐eliciting and (4) full, decision‐making partnerships. Specific examples of how courts and facilities might align with these levels are described. Further, the model makes predictions for how involvement will impact outcomes at multiple levels with applications for other child‐serving systems.  相似文献   
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