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391.
Different time course for the memory facilitating effect of bicuculline in hippocampus, entorhinal cortex, and posterior parietal cortex of rats 总被引:2,自引:0,他引:2
Several lines of evidence indicate that gamma-aminobutyric acid (GABA) type A (GABA(A)) receptors regulate memory consolidation. Here we studied the effect on consolidation of the selective antagonist of GABA(A) receptors, bicuculline, given into several regions of the cortex at different times after one-trial step-down inhibitory avoidance (0.5 mA, 2-s footshock). Rats were bilaterally implanted with cannulae aimed at the CA1 region of the dorsal hippocampus, entorhinal cortex or posterior parietal cortex, three areas known to be involved in the memory consolidation of this task. At different times after training, bicuculline (0.5 microg/side) was infused into the above mentioned structures. Bicuculline increased memory retention when administered either immediately or 1.5h after training into CA1, and both immediately and 3h after training in the entorhinal or parietal cortex. Thus, in agreement with previous findings using other drugs, the response was biphasic in these latter structures. This suggests that GABAergic mechanisms normally downregulate, memory processing by inhibiting on-going activities necessary for consolidation at the times in which bicuculline was effective in each structure. Based on previous findings, in the hippocampus, such activity involves a number of receptors and signaling pathways in the first 1.5h after training. In the entorhinal and parietal cortex memory-related activities include the participation of protein kinase A and extracellularly regulated kinase (ERK) twice, right after training and then again 3h later. 相似文献
392.
Connolly A 《The Journal of analytical psychology》2006,51(2):173-189
This paper discusses the experience of working as an analyst in post-totalitarian Russia in order to explore some of the general theoretical and clinical issues involved in working in a different cultural and linguistic context, and the particular problems encountered in the Russian cultural context. It describes how the Soviet regime worked actively to create a new totally collective mentality through the destruction of individual differences and the collectivization of private space, and the effects this produced in the individual and collective psyche. It examines the difficulties encountered when working with Russian analysands in creating and maintaining the setting, in preserving boundaries, in creating analytical space, and in working with certain particular transference-countertransference dynamics. It focuses on the contrast between my own Western experience of space and the spatial experience of the analysands, and describes the process of helping them use analytical space to interiorize and create a new experience of psychic space. The paper uses dreams to illustrate some of these dynamics, and the particular psychic problems associated with the traumas created by totalitarian regimes. 相似文献
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In the present study, the authors compared 2 frequently used measures to operationalize the construct of the self, namely, the Self-Construal Scale (SCS; T. M. Singelis, 1994) and the Twenty Statements Test (TST; M. Kuhn & T. S. McPartland, 1954), in a sample of 324 male and female undergraduate psychology students of diverse ethnocultural backgrounds. Results demonstrated low intercorrelations between the 2 measures, suggesting that the qualitative and quantitative measures did not evaluate the same construct. A factor analysis of the SCS scale revealed 3 constructs-an independent construct, an interdependent construct, and a power distance or hierarchy construct. Implications for future research included the need for ongoing work in identifying and measuring the constructs of the self. 相似文献
395.
Miller JL Freed-Brown SG White DJ King AP West MJ 《Journal of comparative psychology (Washington, D.C. : 1983)》2006,120(3):229-238
Five variables were studied relating to the emergence of sociality in hand-reared cowbirds (Molothrus ater): proximity, sex assortment, reactions to adults, head-down displays, and vocalizations. The authors were especially interested in female sociality because adult female birds influence male courtship, song content, and use through proximity, attention, and displays. The authors found that young female birds failed to show same-sex affiliation typical of the species at any point in the study. Brief introduction of adults did not affect social patterns. Adults used more head-down displays than juveniles, who used more displays with familiar peers. Directed and undirected singing emerged concurrently; directed singing was positively correlated with earlier hatching. This is the first demonstration of the need for early learning in the development of female sociality. 相似文献
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397.
Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning
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A common cellular alteration, reduced post-burst afterhyperpolarization (AHP) in CA1 neurons, is associated with acquisition of the hippocampus-dependent tasks trace eyeblink conditioning and the Morris water maze. As a similar increase in excitability is correlated with these two learning paradigms, we sought to determine the interactive behavioral effects of training animals on both tasks by using either a consecutive or simultaneous training design. In the consecutive design, animals were trained first on either the trace eyeblink conditioning task for six sessions, followed by training on the water maze task for six sessions, or vice versa. The simultaneous design consisted of six or 11 training days; animals received one session/day of both trace eyeblink conditioning and water maze training. Separate groups were used for consecutive and simultaneous training. Animals trained on both tasks simultaneously were significantly facilitated in their ability to acquire the trace eyeblink conditioning task; no effect of simultaneous training was seen on the water maze task. No effect was seen on acquisition for either task when using the consecutive training design. Taken together, these findings provide insight into how the hippocampus processes information when animals learn multiple hippocampus-dependent tasks. 相似文献
398.
Connolly A 《The Journal of analytical psychology》2002,47(3):359-382
After reviewing the different psychoanalytical approaches to language of authors such as Freud, Lacan, Kristeva, Jung and Nicolas Abraham, the author examines the problem of 'analytical listening', of the attitude that every analyst must assume towards the words of the analysand, words that must be heard not just in terms of their content but above all in terms of their sound. We live in a culture in which visual images predominate over acoustic images and all too often this cultural trend is repeated in analysis, but it is only when we can hear the 'poetry' of the analysand's discourse that we are able to provide an 'echo', an analytical response that can co-symbolize with, that can offer to the analysand a word or a metaphor that will unlock the symbol hidden behind his or her words. The author then turns to the problem of bilinguism and its role in analysis. In her view, bilingual analysts are facilitated in their task of listening and of translation, because bilinguism facilitates the rapidity and fluidity of the analyst's associations, and at the same time sharpens his or her awareness of how the sound of a word can subtly change its meaning. The paper ends with a clinical vignette which illustrates the role that language can play in hysteria. In hysteria the dissociation between body and psyche is accompanied by a dissociation inside language itself, between verbalization and vocalization. These dissociations can be linked to the traumatic impact of the encounter between the 'language of tenderness' and the 'language of passion', between the child's attachment needs and parental sexuality. In such cases the failure of communication can be resolved principally through the use the analyst makes of the countertransference. 相似文献
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400.
RESUMENEl presente trabajo es un estudio empírico longitudinal y transversal de dos grupos de niños de procedencias ambientales diferentes (ambiente familiar y centro de menores) en el que se observan las diferencias en el proceso de desarrollo lingüístico, centrándose en la evolución pragmática del lenguaje mediante la cual se estudia la evolución y construcción de conceptos. Tras definir el procedimiento de estudio y analizar el desarrollo del lenguaje en los sujetos teniendo en cuenta la Longitud Media de los Enunciados (L.M.E.), las autoras concluyen que este desarrollo es mejor en los niños del medio ambiental familiar, diferenciándose también en el ritmo de adquisición y, por tanto, en la evolución del proceso de simbolización. Entre otras cuestiones, los autores destacan que el retraso tanto lingüístico como cognitivo que presentan los niños institucionalizados es consecuencia de la no adecuación de las pautas de interacción adulto-niño exigidas, afirmando que dichas pautas están determinadas por las condiciones ambientales. El trabajo finaliza resaltando que interacción, lenguaje y cognición están dialécticamente interrelacionados. 相似文献