A new theory of absence experience

Ordering your morning coffee and then realising that your wallet is missing from your bag triggers an experience of the absence of your wallet. Familiar cases like this one provide good evidence for the idea that we frequently experience absences. According to one popular view, we experience absences by perceiving them. I argue that there are a number of problems with the perceptual view, and propose an alternative, cognitive account. Now, a cognitive account of absence experience has already been widely discussed and unequivocally rejected by participants in the debate. However, arguments against it depend upon the important, yet mistaken assumption that cognitive accounts must appeal to beliefs or judgements. I argue that the phenomenology involved in absence experience is not that associated with belief or judgement, but is instead an intellectual seeming. This renders my account immune to the objections that have been made against the existing cognitive view.     

Experiences of transgender prisoners and their knowledge,attitudes, and practices regarding sexual behaviors and HIV/STIs: A systematic review

Background: Despite transgender people being more visible in prison systems, research suggests they are at higher risk of experiencing sexual violence compared to other prisoners. Research also suggests that transgender prisoners experience harassment, and physical and sexual assault by fellow prisoners, and prison officers who lack transgender-specific health knowledge. There exist no systematic reviews on the experiences of transgender people in prisons. This review aims to fill this research gap. The following question developed in consultation with transgender, sexual health/HIV and corrective services stakeholders has guided the systematic review: What are transgender and gender-diverse prisoners’ experiences in various prison settings and what are their knowledge, attitudes and practices regarding sexual behaviors and HIV/STIs?

Methods: The review followed the PRISMA guidelines and searches were conducted in four databases for the period of January 2007 to August 2017. Studies were assessed against predetermined inclusion and exclusion criteria. Included studies were peer-reviewed, written in English with online full-text availability and reported data on transgender and gender-diverse prisoner experiences relevant to the research question.

Results: Eleven studies (nine qualitative, one quantitative, one mixed-methods; nine in USA, two in Australia) met the criteria for review. Four studies were of high quality, six were of good/acceptable quality, and one study was of modest quality. Transgender and gender-diverse prisoners reported a range of challenges which included sexual assault, discrimination, stigma, harassment, and mistreatment. Information on their sexual health and HIV/STIs knowledge, attitudes, practices is in short supply. Also, their lack of access to gender-affirming, sexual health/STIs and mental health services is commonplace.

Conclusions: The experiences of transgender prisoners as reported in this review are almost uniformly more difficult than other prisoners. Their “otherness” is used as a weapon against them by fellow prisoners through intimidation and violence (including sexual) and by prison officers through neglect and ignorance.     

A pilot study of urinary peptides as biomarkers for intelligence in old age

Intelligence is an important indicator of physical, mental and social well-being. In old age, intelligence is also associated with a higher quality of life and better health. Heritability studies have shown that there are strong genetic influences, yet unknown, on intelligence, including in old age. Other approaches may be useful to investigate the biological foundations of intelligence differences. Proteomics is a proven technique in revealing biomarkers for certain illnesses. In this pilot study, forty individuals were selected as the cognitive extremes from over 750 people in the Lothian Birth Cohort 1936 (age ~ 72 years) based on their high and low intelligence scores, as measured by a general cognitive ability factor. Urine samples were used as a stable, reliable and abundant source of proteins. Using capillary electrophoresis coupled to mass spectrometry (CE-MS) technology, the proteome of the high and low intelligence groups was determined. Data were calibrated and matched against the human urinary database, to enable comparative assessment. At a nominal significance level (P < 0.05), there were several candidate proteins for association with intelligence, including a zinc finger protein (ZNF653) that has been associated with cognitive deficits, and complement C3 and collagen fragments that have been associated with Alzheimer's disease. Results are preliminary, do not survive multiple testing correction, and require validation. This pilot study shows the potential of this novel proteomics approach, and its applicability to understanding the biological foundations of intelligence differences.