Correspondence between statistically derived behavior problem syndromes and child psychiatric diagnoses in a community sample

The correspondence between Diagnostic and Statistical Manual (3rd ed.) (DSM-III) diagnoses and statistically derived syndromes was examined within a community sample of children and adolescents in Puerto Rico. Specifically, the extent to which behavior dimensions, derived from the Child Behavior Checklist and the Youth Self-Report, corresponded to psychiatric diagnoses, derived from parent and child versions of the Diagnostic Interview Schedule for Children, was examined. The alternative approaches for assessing psychopathology in children and adolescents were compared against external validators. The results indicated a meaningful convergence between DSM-III diagnoses and statistical syndromes; however, a one-to-one correspondence did not emerge. Little evidence was found for diagnostic thresholds. There was no evidence of the superiority of either the statistically derived syndromes or the DSM-III diagnoses. The incorporation of a measure of impairment improved the validity of both approaches. Adding parental reports to the selfreports of adolescents yielded little gain in the validity of either the statistical or diagnostic approach. The implications for the definition and assessment of child and adolescent disorders are discussed.This research was supported by grant MH 38821 from the National Institute of Mental Health.The authors wish to acknowledge Glorisa Canino, Ph.D., and Maritza Rubio-Stipec, M.A., of the University of Puerto Rico, co-investigators in the epidemiologic project and to Barbara Bettes, Ph.D. for her contribution to preliminary analyses for this manuscripl. Portions of this paper were presented at the 38th Annual Meeting of the American Academy of Child and Adolescent Psychiatry, San Francisco, October 1991.     

Non‐generalized and generalized conditioned reinforcers: establishment and validation

Conditioned reinforcers, or tokens, are frequently used in clinical settings; however, little applied research has focused on establishing and validating their effectiveness. Following pairing of a novel token with an edible reinforcer in the present study, preference and reinforcer assessments verified that the tokens functioned as conditioned reinforcers. Results indicated that the tokens were established as conditioned reinforcers that matched the reinforcer value of the primary reinforcers with which they had been paired. The effects of motivating operations (MOs) on the effectiveness of these conditioned reinforcers were then evaluated. Conditioned reinforcer effectiveness decreased during satiation conditions. Subsequently it was found that increasing the number of backup reinforcers with which the token was paired resulted in the effectiveness maintaining during satiation conditions. Copyright © 2008 John Wiley & Sons, Ltd.     

Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice

Ethanol is a frequently abused drug that impairs cognitive processes such as learning. Varenicline, an α4β2 nicotinic receptor partial agonist and α7 nicotinic receptor full agonist prescribed for smoking cessation, has been shown to decrease ethanol consumption. The current study investigated whether varenicline could ameliorate ethanol-induced deficits in learning and whether varenicline alters blood alcohol concentration in C57BL/6 mice. Conditioning consisted of two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)—foot shock unconditioned stimulus (US; 2 s, 0.57 mA) pairings. For all studies, saline or ethanol (1.0, 1.5, 2.0 g/kg i.p.) was administered 15 min before training, and saline or varenicline (0.05, 0.1, 0.2 mg/kg i.p.) was administered 60 min before either training or testing. For blood alcohol analysis, saline or varenicline (0.1 mg/kg) was administered 60 min before collection, and saline or ethanol (1.0, 1.5, 2.0 g/kg) was administered 15 min before collection. Varenicline dose-dependently ameliorated ethanol-induced conditioning deficits for all three doses of ethanol when administered before training but not when administered 24 h later, before testing. In addition, varenicline did not alter blood alcohol concentration. The smoking cessation aid varenicline may have therapeutic uses for treating ethanol-associated disruptions in cognitive processes.     

《马克思的社会本体论——马克思社会实在理论中的个性和共同体·导言》

美国女哲学家古尔德于1978年出版的马克思主义研究专著《马克思的社会本体论》,以马克思的《大纲》(即《1857-1858年经济学手稿》)为文本基础,提出了一个对马克思的新的理解,她认为马克思启动了对传统哲学的根本变革,实现了系统哲学和社会理论的结合,她将马克思视为一个系统的哲学家,并将马克思的这一变革重建为社会本体论.作者围绕五个主要范畴即社会、劳动、因果性、自由和正义详尽地阐发了马克思的社会本体论思想.作为对马克思的解释或理论重建,作者对文本的解读新颖而富有个性,笔者以为本书对于推进国内马克思主义的研究尤其是对于马克思主义哲学的深入研究,有不可忽视的参考价值.     

Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training

Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pairings of an auditory CS and a foot shock US. Multiple doses of nicotine were given before or immediately after training and on testing day (0.0, 0.050, 0.125, 0.250, and 0.375 mg/kg, i.p). Freezing to both the context and auditory CS was measured 24h after training and again 1 week after training. Mice did not receive nicotine for the 1-week retest. Nicotine (0.125 and 0.250 mg/kg) given on both training and testing days enhanced freezing to the context at 24h. In addition, elevated freezing to the context was seen 1 week post-training in mice previously treated with 0.125 and 0.250 mg/kg nicotine. Thus, nicotine-treated mice did show elevated levels of freezing when retested 1 week later, even though no nicotine was administered at the 1-week retest. Mice that received nicotine on training day or testing day only and mice that received nicotine with mecamylamine, a nicotinic receptor antagonist, were not different from saline-treated mice. In addition, post-training administration of nicotine did not enhance fear conditioning. The present results indicate that nicotine enhancement of contextual fear conditioning depends on administration of nicotine on training and test days but results in a long-lasting enhancement of memories of contextual fear conditioning that remains in the absence of nicotine.     

Age-related impairment in the 250-millisecond delay eyeblink classical conditioning procedure in C57BL/6 mice

In this study we tested 4-, 9-, 12-, and 18-month-old C57BL/6 mice in the 250-msec delay eyeblink classical conditioning procedure to study age-related changes in a form of associative learning. The short life expectancy of mice, complete knowledge about the mouse genome, and the availability of transgenic and knock-out mouse models of age-related impairments make the mouse an excellent species for expanding knowledge on the neurobiologically and behaviorally well-characterized eyeblink classical conditioning paradigm. Based on previous research with delay eyeblink conditioning in rabbits and humans, we predicted that mice would be impaired on this cerebellar-dependent associative learning task in middle-age, at ~9 months. To fully examine age differences in behavior in mice, we used a battery of additional behavioral measures with which to compare young and older mice. These behaviors included the acoustic startle response, prepulse inhibition, rotorod, and the Morris water maze. Mice began to show impairment in cerebellar-dependent tasks such as rotorod and eyeblink conditioning at 9 to 12 months of age. Performance in hippocampally dependent tasks was not impaired in any group, including 18-month-old mice. These results in mice support results in other species, indicating that cerebellar-dependent tasks show age-related deficits earlier in adulthood than do hippocampally dependent tasks.     

Is the future always brighter than the past? Anticipation of changes in the personal future after recall of past experiences

People tend to hold an optimistic view of their futures. Using a novel paradigm to examine the anticipated change from the personal past to the personal future, we found that the future was not always perceived as brighter than the past. College students (N = 156) recalled positive and negative personal events of various situations. Following each recall, they imagined a future personal event involving the same situation. Participants expected over half of the events to change in either upward or downward directions, depending on the valence of the past events. In addition, participants anticipated greater changes in domains of less stability, and Asians anticipated greater changes than European Americans. Anticipated future changes were further associated with psychological well-being. The findings shed new light on future event simulation.     

Bernard Williams: Political Realism and the Limits of Legitimacy

Abstract: A central component of Bernard Williams' political realism is the articulation of a standard of legitimacy from within politics itself: LEG. This standard is presented as basic, inherent in all political orders and the best way to underwrite fundamental liberal principles particular to the modern state, including basic human rights. It does not require, according to Williams, a wider set of liberal values. In the following, I show that where Williams restricts LEG to generating only minimal political protections, seeking to isolate his account of political legitimacy from a range of liberal principles, this is neither internal to, nor necessarily demanded by, the specifically political account of LEG. Instead, the limitation depends upon his wider ethical thought.     

Adolescent mice,unlike adults,consume more alcohol in the presence of peers than alone

One hallmark of adolescent risk‐taking is that it typically occurs when adolescents are with peers. It has been hypothesized that the presence of peers primes a reward‐sensitive motivational state that overwhelms adolescents' immature capacity for inhibitory control. We examined this hypothesis using a rodent model. A sample of mice were raised in same‐sex triads and were tested for alcohol consumption either as juveniles or as adults, with half in each age group tested alone and half tested with their cagemates. The presence of ‘peers’ increased alcohol consumption among adolescent mice, but not adults. The peer effect on human adolescent reward‐seeking may reflect a hard‐wired, evolutionarily conserved process through which the presence of agemates increases individuals' sensitivity to potential rewards in their immediate environment.     

The assessment and management of suicide risk: state of workshop education

A systematic search of popular and scholarly databases identified workshops that addressed general clinical competence in the assessment or management of suicide risk, targeted mental health professionals, and had at least one peer-reviewed publication. We surveyed workshop developers and examined empirical articles associated with each workshop. The state of workshop education is characterized by presenting the learning objectives, educational formats, instructor factors, and evaluation studies. Workshops are efficacious for transferring knowledge and shifting attitudes; however, their role in improving clinical care and outcomes of suicidal patients has yet to be determined.