骨源性因子ucOCN在运动抗抑郁中的作用机制

羧化不全骨钙素(ucOCN)是骨中成骨细胞分泌的特异性蛋白,因其在调控神经发育、神经可塑性等中的重要角色而受到神经科学领域关注。"骨-脑"串联"对话"是骨内分泌-神经介导的应答系统,ucOCN透过血脑屏障后介导单胺类神经递质、神经内分泌、神经免疫、神经再生及基因表达等机制,进而作用于海马CA3区、扣带回等脑区功能发挥来调节抑郁发生及改善。而ucOCN作为骨源性力学刺激敏感基因,运动上调其表达后进入血液循环,通过介导5-HT/GABA分泌、HPA轴功能、炎症反应、神经营养因子(BDNF等)表达或信号途径(如GSK3β/β-catenin、TLR4/miR-223/NLRP3等)激活等来实现"骨串联脑",发挥运动抗抑郁作用。通过对骨源性因子ucOCN介导脑区功能变化从而实现运动抗抑郁的作用机制进行探讨、梳理,一方面有助于更深入了解骨内分泌功能,另一方面为抑郁发生、改善和运动抗抑郁研究提供新的理论基础和研究思路。     

视觉注意捕获的快速脱离假说与信号抑制假说

快速脱离假说和信号抑制假说都是将传统的自下而上捕获和自上而下控制结合起来的混合模式假说。快速脱离假说认为突显干扰物总能在第一时间自下而上地捕获注意, 当突显干扰物与任务要求不符时, 注意会迅速脱离该位置。信号抑制假说认为突显干扰物都会产生“注意我”的信号, 当突显干扰物与任务要求不符时, 该信号会被自上而下地抑制以阻止注意捕获发生。前者相关的研究多采用空间线索提示范式和眼动脱离范式, 实验中被试采取独子探测策略, 而后者相关的研究多采用额外单例范式的变式, 实验中被试采取特征探测策略。未来研究应采用不同的刺激类型和实验方法进一步为两个假说提供证据支持, 同时要关注奖赏、训练等因素对“捕获-脱离”和“信号-抑制”的影响。     

Examining the item response process to personality measures in high-stakes situations: Issues of measurement validity and predictive validity

We conducted two experimental studies with between-subjects and within-subjects designs to investigate the item response process for personality measures administered in high- versus low-stakes situations. Apart from assessing measurement validity of the item response process, we examined predictive validity; that is, whether or not different response models entail differential selection outcomes. We found that ideal point response models fit slightly better than dominance response models across high- versus low-stakes situations in both studies. Additionally, fitting ideal point models to the data led to fewer items displaying differential item functioning compared to fitting dominance models. We also identified several items that functioned as intermediate items in both the faking and honest conditions when ideal point models were fitted, suggesting that ideal point model is “theoretically” more suitable across these contexts for personality inventories. However, the use of different response models (dominance vs. ideal point) did not have any substantial impact on the validity of personality measures in high-stakes situations, or the effectiveness of selection decisions such as mean performance or percent of fakers selected. These findings are significant in that although prior research supports the importance and use of ideal point models for measuring personality, we find that in the case of personality faking, though ideal point models seem to have slightly better measurement validity, the use of dominance models may be adequate with no loss to predictive validity.     

An empirical look at the Defense Mechanism Test (DMT): reliability and construct validity

Although the Defense Mechanism Test (DMT) has been in use for almost half a century, there are still quite contradictory views about whether it is a reliable instrument, and if so, what it really measures. Thus, based on data from 39 female students, we first examined DMT inter-coder reliability by analyzing the agreement among trained judges in their coding of the same DMT protocols. Second, we constructed a "parallel" photographic picture that retained all structural characteristic of the original and analyzed DMT parallel-test reliability. Third, we examined the construct validity of the DMT by (a) employing three self-report defense-mechanism inventories and analyzing the intercorrelations between DMT defense scores and corresponding defenses in these instruments, (b) studying the relationships between DMT responses and scores on trait and state anxiety, and (c) relating DMT-defense scores to measures of self-esteem. The main results showed that the DMT can be coded with high reliability by trained coders, that the parallel-test reliability is unsatisfactory compared to traditional psychometric standards, that there is a certain generalizability in the number of perceptual distortions that people display from one picture to another, and that the construct validation provided meager empirical evidence for the conclusion that the DMT measures what it purports to measure, that is, psychological defense mechanisms.     

Extension of Luria's Psycholinguistic Studies in Poland

One of Luria's basic interests was the organization of human cognitive processes, and thinking in particular. He believed that language and thought are closely related, and hence the manner in which we speak reflects the way we think. To verify this assumption, he and his collaborators performed a number of interesting psycholinguistic experiments with subjects of various ages and cultural backgrounds. The tasks used made the evaluation of both receptive and expressive language possible. The Narrative Ability Test described here stems from Luria's observations to a considerable degree. The test was administered to preschool children (N = 106), schoolchildren (N = 143), adolescents (N = 89), adults (N = 126), and older persons (N = 175). Findings of the 20-year studies with normal and deviant populations indicate close relationships among thought, language, and self-control. It was found that difficulty in developing narratives corresponds with a disability to process complex information. Correlations between narrative skills and age, sex, and social background were also noted.     

血栓形成及抗凝药物在临床应用中的思考

血栓栓塞性疾病对人类的健康已构成了极大的危害.在临床工作中应深入了解血栓形成以及凝血机制的新概念,了解传统抗凝药物的特点、以及凝血因子靶点Ⅹa、Ⅱa等特异性抑制为基础的新型抗凝药物的研发进展,合理使用抗凝药物,提高对血栓栓塞性疾病的诊治水平.