Signaling Mechanisms Mediating BDNF Modulation of Synaptic Plasticity in the Hippocampus

Although recent studies indicate that brain-derived neurotrophic factor (BDNF) plays an important role in hippocampal synaptic plasticity, the underlying signaling mechanisms remain largely unknown. Here, we have characterized the signaling events that mediate the BDNF modulation of high-frequency synaptic transmission. Mitogen-associated protein kinase (MAPK), phosphotidylinositol-3 kinase (PI3K), and phospholipase C-γ (PLC-γ) are the three signaling pathways known to mediate neurotrophin signaling in other systems. In neonatal hippocampal slices, application of BDNF rapidly activated MAPK and PI3K but not PLC-γ. BDNF greatly attenuated synaptic fatigue at CA1 synapses induced by a train of high-frequency, tetanic stimulation (HFS). Inhibition of the MAPK and PI3K, but not PLC-γ, prevented the BDNF modulation of high-frequency synaptic transmission. Neurotrophin-3 (NT-3), a close relative of BDNF, did not activate MAPK or PI3K and had no effect on synaptic fatigue in the neonatal hippocampus. Neither forskolin, which activated MAPK but not PI3 kinase, nor ciliary neurotrophic factor (CNTF), which activated PI3K but not MAPK, affected HFS-induced synaptic fatigue. Treatment of the slices with forskolin together with CNTF still had no effect on synaptic fatigue. Thus, although the activation of MAPK and PI3K is required, the two together are not sufficient to mediate the BDNF effect. Inhibition of new protein synthesis by anisomycin or cycloheximide did not prevent the BDNF effect. These data suggest that BDNF modulation of high-frequency transmission is independent of protein synthesis but requires MAPK and PI3K and yet another signaling pathway to act together in the hippocampus.     

Maturity Levels for Outlaw Groups: The Case of Criminal Street Gangs

The maturity of street gangs varies among groups as well as among countries where gangs are present. In this article, a four stage model for maturity is introduced to help define the threat represented by outlaw groups. Maturity models can serve several important purposes. First, a contingent approach to law enforcement implies that the police and other government agencies can apply appropriate measures. Second, law enforcement can distinguish approaches for fighting non-mature gangs versus mature gangs. Third, the evolution of gangs over time provides insights into the mechanisms that make gangs threatening to society.     

Convenience in White-Collar Crime: Introducing a Core Concept

This article is concerned with white-collar criminals and considers the role of convenience in explaining crime occurrence. The article puts forward convenience as a theoretical concept that underlies existing theories and research on white-collar crime. Convenience seems present in all three dimensions of crime: economic dimension, organizational dimension, and behavioral dimension. Convenience in white-collar crime implies savings in time and effort by privileged and trusted individuals to solve a problem, where alternatives seem less attractive, and future threats of detection and punishment are minimal. The proposed theory of convenience in white-collar crime emerges as an integrated explanation in need of more theoretical work as well as empirical study.     

The effects of establishing operations on preference assessment outcomes

Preference assessments were conducted for 4 individuals with developmental disabilities across conditions of (a) control, allowing equal access to all stimuli prior to the preference assessment; (b) deprivation, allowing no access to one stimulus for 48 hr prior to the assessment; and (c) satiation, allowing free access to one stimulus for 10 min immediately prior to the assessment. Deprivation resulted in increased preference, whereas satiation resulted in decreased preference compared to control conditions.     

Psychological skills and mindfulness training effects on the psychological wellbeing of undergraduate music students: An exploratory study

This study explored the efficacy of psychological skills and mindfulness training intervention on the psychological wellbeing of undergraduate music students. Participants were undergraduate music students (n = 36) from the Department of Music at a South African university, 21 of whom were elected to take the psychological skills and mindfulness training intervention. Data on their self-reported psychological wellbeing, psychological skills, mindfulness and performance anxiety levels were collected pre-and post-intervention. The analysis applied non-parametric procedures to determine changes in students’ psychological wellbeing after the seven-week intervention programme. Findings suggest improvements in psychological wellbeing, psychological skills, mindfulness and performance anxiety with training. Psychological skills and mindfulness training may have benefits to the psychological wellbeing of music students.     

Blame game in private investigation reports: The case of Deloitte examination at Telenor VimpelCom

Business and public organisations hire fraud examiners to conduct private investigations when there is suspicion of misconduct or financial crime. Fraud examiners carry out their investigation based on a mandate. Often, individuals in the organisation are suspects. The blame game hypothesis is concerned with factors that cause blame attribution to some individuals but not to others. In this case study, only executives were blamed who had not disclosed corruption information to a major shareholder and to the chief executive officer.     

Determinants of fraud examination performance: An empirical study of internal investigation reports

Fraud examiners from global auditing firms and local law firms are in the business of private policing by conducting internal investigations in private and public organisations when there is suspicion of financial crime. The business is often characterised by secrecy, and reports of investigations are often difficult or impossible to disclose. Since 2012, we have successfully retrieved 63 fraud examination reports in Scandinavia. Based on these reports, this article presents a statistical analysis of fraud examination performance. Performance was measured in terms of the extent of successful reconstruction of past events and the extent of justification of conclusions from the examinations. We identified three statistically significant determinants of fraud examination performance: the seriousness of the consequences, the relative seriousness of the consequences and the conclusions, and the seriousness of the conclusions.     

Theory of Convenience: Determinants of White-Collar Crime Intention

ABSTRACT

Crime intentions are an important area of research in criminology. Yet substitutes for real intentions have to be applied since respondents will be reluctant to tell truthfully of their tendency to commit a crime. In this article, we present determinants of white-collar crime based on the theory of convenience. Convenience theory suggests that the extent of individual convenience orientation determines to what extent a person of respectability and high social status in the course of his or her occupation will make a decision to violate the law whenever alternative decisions are less convenient. A more stressful and greedy financial motive, an improved organizational opportunity to commit and conceal crime, and a stronger personal willingness for deviant behavior are assumed to influence the extent of white-collar crime intention. Based on a survey of business school students, we find support for suggested causal relationships in the theory of convenience. Business school students are relevant for this research, as they will occupy positions in the future where they can commit financial crime, prevent crime, or become victims of such crime.     

Islamophobic and anti-Muslim resistance to postsecularism: South Asian Americans and the disciplining of American racial and religious subjectivities*

ABSTRACT

Assaults on Sikhs and other South Asian Americans represent not merely cases of ‘mistaken Muslims.’ Their victimization is different—yet not distinct—from anti-Muslim sentiment. They are the casualties of an American racial and secular nationalist project to discipline citizens into a ‘safe’ religious subjectivity. Although a variety of Hollywood films demonstrate a slowly growing sophistication in portrayals of Muslims, Islamic traditions, and South Asian Americans, too many continue to promote America’s sometimes fatal conflation of race and religion that becomes particularly acute in periods of strident nativism.