Effects of social isolation and environmental enrichment on atherosclerosis in ApoE-/- mice

Social support and a stimulating environment have been suggested to reduce stress reactions and cardiovascular risk. The aim of this study was to assess the role of environmental enrichment and social interaction for development of atherosclerosis in atherosclerosis prone mice. Male ApoE-/- mice were divided into four groups and followed during 20 weeks: (i) enriched environment (E, n=12), (ii) deprived environment (ED, n=12), (iii) enriched environment with exercise (E-Ex, n=12) and (iv) socially deprived by individual housing (SD, n=10). Plasma lipid and cytokine concentrations were measured. Atherosclerosis was quantified in cross-sections of innominate artery and en face in thoracic aorta. Plaque area was significantly increased in SD mice in the innominate artery (P<0.05 vs. all other groups), but not in the thoracic aorta. Plasma lipids were increased in SD mice (P<0.001 vs. all for total cholesterol, P<0.05 vs. E and P<0.01 vs. ED for triglycerides). Plasma concentration of granulocyte-colony stimulating factor (G-CSF) was decreased in SD mice compared to E mice (P<0.05). Thus, social isolation increased atherosclerosis and plasma lipids in ApoE-/- mice. Reduction in plasma G-CSF levels may hamper endothelial regeneration in the atherosclerotic process. While environmental enrichment did not affect atherosclerosis, social isolation accelerated atherosclerosis.     

Lifecourse Social Conditions and Racial and Ethnic Patterns of Cognitive Aging

A lifecourse perspective is key for understanding and interpreting racial and ethnic patterns in neuropsychological test performance. In this article, we discuss contextual factors that shape the environmental conditions encountered by racial and ethnic minorities in the United States, in particular African-Americans. These conditions include geographic segregation at the level of regions, metropolitan areas, and neighborhoods; intra- and inter-national migration patterns; socioeconomic position, including financial resources, and occupational and educational opportunities; discrimination; and group resources. Each of these exposures sets in course a cascade of individual mediators that ultimately manifest in neuropsychological outcomes. The physiological and behavioral consequences of these pathways likely accumulate across the lifecourse. We focus on cognitive aging, although the processes discussed here begin in infancy and likely influence cognitive outcomes throughout life from childhood into old age. A lifecourse framework can help inform clinical encounters, neuropsychological research, and surveillance regarding the population prevalence of cognitive impairments.     

Variations on an old theme: maternity for women with a very successful professional career

In this study, relationships of middle-class women from Rio de Janeiro with their family and work are presented. A series of events during the 20th century have changed woman's identity, previously centered on the roles of mother and wife, so that, there are now other options for women. Carioca girls are currently educated to compete, seek greater professional growth, and value their independence. However, some social discourses still reinforce women's former role the in the family. The notion that the mother-child unit is basic, universal, and, psychologically, the most appropriate, both for the child's healthy development and the mother's wholeness, is still firmly rooted. Motherhood is therefore one of the most complex and problematic matters for modern Carioca woman. Fifteen women with successful professional careers, residents of the city of Rio de Janeiro, varying in age from 30 to 40, and with children from 6 months to 3 years of age, were interviewed. The interviews had an invisible structure, were recorded and transcribed. The discourse of the resultant texts was analyzed, using the categories I established. In this project, I focus on the results of the analysis of the category "View of Maternity" of the interviewed women.     

Age-of-acquisition and subjective frequency estimates for all generally known monosyllabic French words and their relation with other psycholinguistic variables

Ratings for age of acquisition (AoA) and subjective frequency were collected for the 1,493 monosyllabic French words that were most known to French students. AoA ratings were collected by asking participants to estimate in years the age at which they learned each word. Subjective frequency ratings were collected on a 7-point scale, ranging from never encountered to encountered several times daily. The results were analyzed to address the relationship between AoA and subjective frequency ratings with other psycholinguistic variables (objective frequency, imageability, number of letters, and number of orthographic neighbors). The results showed high reliability ratings with other databases. Supplementary materials for this study may be downloaded from the Psychonomic Society’s Archive of Norms, Stimuli, and Data, www.psychonomic.org/archive.     

Emotional prejudice,essentialism, and nationalism The 2002 Tajfel lecture

In explaining differences between groups, people ascribe the human essence to their ingroup and consider outgroups as less human. This phenomenon, called infra‐humanization, occurs outside people's awareness. Because secondary emotions (e.g. love, hope, contempt, resentment) are considered uniquely human emotions, people not only attribute more secondary emotions to their ingroup than to outgroups, but are reluctant to associate these emotions with outgroups. Moreover, people behave less cooperatively (in terms of altruism, imitation, and approach) with an outgroup member who expresses himself through secondary emotions. Infra‐humanization occurs for high and low status groups, even in the absence of conflict between groups. It does not occur when the outgroup target is adequately individualized, by a complete name or through perspective taking, for instance. The differential familiarity with the ingroup and the outgroup cannot explain infra‐humanization. Yet, preliminary results show that subjective essentialism and ingroup identification may mediate the effects of infra‐humanization. A connection is made between nationalism and infra‐humanization. Copyright © 2003 John Wiley & Sons, Ltd.     

Does it matter where you work? A comparison of how three work venues (traditional office, virtual office, and home office) influence aspects of work and personal/family life

Millions use electronic tools to do their jobs away from the traditional office. Some labor in a “virtual office” with flexibility to work wherever it makes sense and others telecommute primarily from home. This IBM study compares how three work venues (traditional office, n=4316, virtual office, n=767, and home office, n=441) may influence aspects of work (job performance, job motivation, job retention, workload success, and career opportunity) and personal/family life (work/life balance and personal/family success). Perceptions, direct comparisons, and multivariate analyses suggest that the influence of the virtual office is mostly positive on aspects of work but somewhat negative on aspects of personal/family life. The influence of the home office appears to be mostly positive and the influence of traditional office mostly negative on aspects of both work and personal/life. Implications of these findings are discussed.     

When prototypicality makes ‘maybes’ look more certain: Another look at targets' vigilance towards prejudice cues

In previous research, targets' sensitivity to prejudice cues has been assessed on the basis of two types of information. Prototypical information renders the situation representative of discrimination encountered by the ingroup. Diagnostic information is a direct indication that prejudice possibly is operating in a given situation. We hypothesize that, when available and processed at the onset of an evaluation situation, prototypical information shapes targets' understanding of subsequent diagnostic information. In three experiments, participants were informed that they were to be evaluated by relevant outgroup members either before or after having performed a task. Diagnostic information was always provided at the same moment, i.e. after the task was completed, and was either uncertain (prejudice may bias the evaluation) or certain (prejudice certainly biases the evaluation). In the before condition, attributions to prejudice were as elevated whatever participants were told that prejudice might, or certainly did, bias the evaluation. Furthermore, in the case of uncertain diagnostic information, those who were readily informed of the evaluator(s)' identity attributed their failure to prejudice to a greater extent than those who received this information later. Copyright © 2004 John Wiley & Sons, Ltd.