要注意中药对肝的损伤作用

含有生物碱类、皂苷类、萜类、毒蛋白类、重金属类成分的中药易致急性肝损伤.中药对肝脏损伤的原因及机制较为复杂,可能与药物对肝脏的直接毒性或特异性体质有关.此外,中药炮制方法、给药途径、剂型、剂量、疗程及配伍不当也会引起药物性肝损伤.中药所致的药物性肝损伤的诊断主要依据用药史、发病的时间、过程和临床表现并排除其他因素.治疗可选用还原型谷胱甘肽、S-腺苷蛋氨酸、多烯磷脂酰胆碱、熊去氧胆酸、水飞蓟素等药物,重症可选择人工肝脏支持治疗.     

阿尔茨海默病生物学标志物研究进展

阿尔茨海默病（AD）是常见的中枢神经系统变性疾病,是痴呆最常见的病因,发病率高.病理特征为老年斑及神经元纤维缠结.AD的确诊有赖病理学,临床诊断极其耗时.由于尚无准确的早期诊断方法,常使AD患者错过早期治疗的时机,这成为制约有效防控AD的瓶颈问题.因此寻找高敏感性、特异性、无创性的生物学标志物对AD的早期诊断至关重要.本文仅将目前较为广泛研究的生物学标志物及其研究现状作一概述.分别对脑脊液、血液、尿液及唾液中的AD标志物作逐一介绍.     

开腹手术后早期炎性肠梗阻的诊断与综合治疗

总结术后早期炎性肠梗阻的临床治疗经验及防治措施.回顾性分析36例腹部手术后早期炎性肠梗阻患者临床治疗方法.33例经非手术治疗治愈,平均治愈时间(15.5±9.5)d,1例自动出院,2例转往上级医院进一步治疗.腹部手术后早期炎性肠梗阻应以保守治疗为主,有效的治疗包括禁食、胃肠减压、全肠外营养支持、糖皮质激素和生长抑素的应用.炎性肠梗阻选择非手术治疗,既保证了治疗的有效性,同时也能够让患者接受.     

Too exhausted to remember: Ego depletion undermines subsequent event‐based prospective memory

Past research has consistently found that people are likely to do worse on high‐level cognitive tasks after exerting self‐control on previous actions. However, little has been unraveled about to what extent ego depletion affects subsequent prospective memory. Drawing upon the self‐control strength model and the relationship between self‐control resources and executive control, this study proposes that the initial actions of self‐control may undermine subsequent event‐based prospective memory (EBPM). Ego depletion was manipulated through watching a video requiring visual attention (Experiment 1) or completing an incongruent Stroop task (Experiment 2). Participants were then tested on EBPM embedded in an ongoing task. As predicted, the results showed that after ruling out possible intervening variables (e.g. mood, focal and nonfocal cues, and characteristics of ongoing task and ego depletion task), participants in the high‐depletion condition performed significantly worse on EBPM than those in the low‐depletion condition. The results suggested that the effect of ego depletion on EBPM was mainly due to an impaired prospective component rather than to a retrospective component.     

Exploring trust of mobile applications based on user behaviors: an empirical study

This paper explores trust of mobile applications based on users' behaviors. It proposes a trust behavior construct through principal component analysis, reliability analysis, and confirmatory factor analysis based on the data collected from a questionnaire survey with more than 1,500 participants. It is indicated that a user's trust behavior is composed of three principal constructs: using behavior, reflection behavior, and correlation behavior. They are further delineated into 12 measurable sub‐constructs and relate to a number of external factors. The data analysis showed that the questionnaire has positive psychometric properties with respect to construct validity and reliability. We also discuss the practical significance and limitations of our work toward usable trust management.     

Practice Effects on Motor Control in Healthy Seniors and Patients with Mild Cognitive Impairment and Alzheimer's Disease

ABSTRACT

This research was designed to test the hypothesis that motor practice can enhance the capabilities of motor control in healthy controls (NC) and patients with a diagnosis of probable Alzheimer's disease (AD) and mild cognitive impairment (MCI), and consequently results in better motor performance. Approximately half of the subjects in the NC (n = 31), AD (n = 28), and MCI (n = 29) either received or did not receive practice on a task of fast and accurate arm movement with a digitizer. Changes in movement time (MT), movement smoothness (jerk), and percentage of primary submovement (PPS) were recorded and compared among the three groups across six blocks of trials (baseline and five training sessions). For all subjects, practice improved motor functions as reflected by faster and smoother motor execution, as well as a greater proportion of programming control. Compared to unaffected matched controls, AD and MCI subjects exhibited a greater reduction in movement jerk due to practice. Movement time and PPS data revealed that motor practice appeared to reduce the use of “on-line” correction adopted by the AD or MCI patients while performing the aiming movements. Evidently, their arm movements were quicker, smoother, and temporally more consistent than their untrained peers. The findings of this study shed light on how MCI and AD may affect motor control mechanisms, and suggest possible therapeutic interventions aimed at improving motor functioning in these impaired individuals.     

两例先天性无痛症患者的心理生理特点研究 Ⅱ.对致痛性强刺激的知觉和反应

本工作对两例先天性无痛症患者对于致痛性强刺激的知觉和反应进行了研究(例1女,10岁,例2男,13岁)。对照组为20例正常儿童,性别和年龄均与患儿相匹配。 结果:1),生活中痛:两例患儿均无(包括痛感觉和痛反应)。2)实验性痛:①痛感觉:两例患儿均无;②“痛”反应:例1有“痛”反应(脉搏和呼吸的变化以及行为反应明显,大致与正常儿童相似)。例2无“痛”反应(脉搏和呼吸的变化轻微,无行为反应,与正常儿童不同)。 由结果看来,先天性无痛症患者似乎可分为两种类型:不完全型(如同例1)和完全型(如同例2)。存在有“痛”反应而无痛感觉的无痛症患者。 本工作结果从另一侧面为痛的两成分学说提供了依据。     

As the Flocks Gather: How Religion Affects Voluntary Association Participation

This study investigates the relationship between different dimensions of religiosity and voluntary association participation using data from Queen'sUniversity's 1996 "God and Society in North America" survey. I look at the participatory, devotional, affiliative, and theological dimensions of religiosity and examine how they affect voluntary association participation at three different levels: membership, volunteering, and serving on a committee. The results show that all four religious dimensions have considerable, but distinctive, influences on secular voluntary association participation.     

中学教师处理学生心理健康问题策略特点探析

采用问卷法考察了268名中学教师在厌学、退缩行为、自我中心、攻击性行为和考试焦虑五种问题情境下教师对处理学生心理健康问题的策略有效性和使用可能性的评定以及性别、教龄因素对教师评定策略有效性的影响。结果表明:(1)中学教师处理学生心理健康问题策略具有情境性,教师对处理学生心理健康问题的策略的有效性的认可和真正在具体情境中采取的策略不尽相同。在厌学和退缩行为情境中,教师倾向于认为情感关爱型策略更有效;自我中心情境中,行为疏导型策略更有效;攻击行为情境中,惩罚约束型策略更有效;在焦虑情境中,言语疏导型策略更有效。在采用可能性的评定中,对学生的厌学、退缩行为、自我中心和焦虑问题,教师都更倾向于采用言语疏导型策略;在攻击行为情境中,教师更倾向于采用行为疏导型策略。(2)与性别相比,教龄是影响教师评定处理学生心理健康问题策略有效性的较为敏感的变量。在厌学情境中,20年以上教龄的教师认为责任转移型策略和情感关爱型策略更有效;在自我中心情境中,20年以上教龄的教师认为责任转移型策略更有效。     

Messages about sex in the workplace: A content analysis of primetime television

Because television has the potential to shape cultural beliefs about both sexual norms and appropriate workplace behavior, it seems important to examine TV’s portrayal of “sexual etiquette” in the workplace. In a content analysis of two episodes of every primetime comedy aired on all broadcast and cable networks during fall 2000, we coded every sexual remark and behavior made in a workplace scene. Across all networks, 85 percent of programs and one in four workplace interactions contained some type of sexual content. Overall, a viewer is likely to hear eleven sexual remarks and see two to three sexual behaviors in a workplace setting per hour; this jumps to twenty-three remarks and nine behaviors on cable networks. Sexual remarks were mostly explicit, made in an office setting, by White men, and were rarely (1.4%) about sexual harassment or discrimination. Although sexual content in the workplace was generally less common on broadcast than cable networks, a broadcast network (Fox) actually had the highest overall rate, with sexual content in 38 percent of workplace scenes. Given that research suggests that TV teaches youth about sexuality and cultivates sexual attitudes and beliefs consistent with televised portrayals, it is alarming that youth may learn from television that sex in the workplace is not only commonplace, but also to be tolerated and enjoyed.