视觉长时记忆激活度对促进视觉短时记忆的影响

短时记忆与长时记忆的关系是记忆领域研究的重要内容。基于此, 研究者们就视觉长时记忆是否能促进视觉短时记忆的问题展开了大量研究, 但所得出的结论并不一致。通过不同程度的学习形成不同激活度的视觉长时记忆, 考察对几何图形的视觉长时记忆是否能对变化检测中的短时记忆起到促进作用。结果发现, 低激活水平的视觉长时记忆不能促进视觉短时记忆, 而事先存在且高度激活的视觉长时记忆对视觉短时记忆却具有促进作用; 同时, 随着视觉长时记忆激活水平的提高, 刺激间间隔的效应值也逐渐减小。本研究说明, 视觉长时记忆能否促进视觉短时记忆取决于视觉长时记忆的激活水平, 高激活的视觉长时记忆对阻止视觉短时记忆痕迹的迅速消退具有重要意义。     

基于网络新闻报道的医院暴力伤害事件研究

通过自行设计的网络调查表,对以网络搜索引擎收集到的2013年1月~2014年3月我国网络新闻报道的医院暴力伤害事件进行逐条筛选,并对符合纳入标准的严重医院暴力伤害事件进行分析,了解我国医院暴力伤害事件的发生特征与发生规律,为今后进行有针对性的干预与防治提供重要线索,同时提醒医务人员警惕医院暴力伤害事件发生的高危因素以及高危人群,做好重点防范措施。随着计算机和网络信息技术的迅猛发展,网络媒体可以成为干预医院暴力伤害事件高发的重要途径和研究的重要数据补充来源。     

英国本科医学教育培养目标的嬗变——基于《明日的医生》报告的解读

英国医学总会在1993年、2003年和2009年先后出版了三份《明日的医生》报告,为本科医学教育提供了综合性框架,指导本科医学课程设计和评价体系的形成。从知识、技能、医学伦理和职业道德三个层面,比较英国本科医学教育人才培养目标的嬗变,发现其要求不断趋于全面、细化、深入。并进一步分析了政治、多元文化、国家医疗政策、医学领域自身及医学教育内部等诸因素对英国本科医学教育的影响,以期为我国的本科医学教育提供借鉴。     

Automated assessment of conditioning parameters for context and cued fear in mice

A behavioral technique often used to evaluate the cognitive performance of rats and mice is the fear conditioning paradigm. During conditioned fear experiments, freezing responses shown by rodents after exposure to environmental stimuli previously paired to an aversive experience provide a behavioral index of the animal's associative abilities. The present study examined the ability of a computer-controlled automated Freeze Monitor system for recording immobility behavior in mice. The sensitivity of the automated procedure to detect group differences caused by the application of various training protocols was also evaluated. Statistical analyses revealed significant positive correlations between immobility scores obtained with the automated apparatus and hand-scored data collected by a continuous or a time-sampling method. Behavioral patterns recorded by the computerized system were very similar to those obtained by the hand-scoring methods adopted. In particular, during context testing, exposure to environmental stimuli previously paired with a mild foot shock (unconditioned stimulus [US]) evoked increased immobility behavior in mice conditioned with the US compared with levels of immobility displayed by mice previously confined to the same contextual stimuli without receiving the US. Moreover, although during conditioned stimulus (CS) testing, mice previously exposed to the US displayed high levels of immobility when confined to environmental cues much different from those paired with the US (contextual fear generalization), both hand-scored and automated results revealed the effect of CS–US pairing (increased immobility) only in mice trained to associate the two stimuli (paired group) but not in mice exposed to both CS and US separated by a 40-sec time interval (unpaired group) or in mice receiving only the US (US group) during conditioning sessions. Overall, the results show associative conditioning measured in an automated apparatus and highlight the utility of obtaining both latency as well as beam interruption parameters.     

Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals

Individuals from across the psychosis spectrum display impairments in reinforcement learning. In some individuals, these deficits may result from aberrations in reward prediction error (RPE) signaling, conveyed by dopaminergic projections to the ventral striatum (VS). However, there is mounting evidence that VS RPE signals are relatively intact in medicated people with schizophrenia (PSZ). We hypothesized that, in PSZ, reinforcement learning deficits often are not related to RPE signaling per se but rather their impact on learning and behavior (i.e., learning rate modulation), due to dysfunction in anterior cingulate and dorsomedial prefrontal cortex (dmPFC). Twenty-six PSZ and 23 healthy volunteers completed a probabilistic reinforcement learning paradigm with occasional, sudden, shifts in contingencies. Using computational modeling, we found evidence of an impairment in trial-wise learning rate modulation (α) in PSZ before and after a reinforcement contingency shift, expressed most in PSZ with more severe motivational deficits. In a subsample of 22 PSZ and 22 healthy volunteers, we found little evidence for between-group differences in VS RPE and dmPFC learning rate signals, as measured with fMRI. However, a follow-up psychophysiological interaction analysis revealed decreased dmPFC-VS connectivity concurrent with learning rate modulation, most prominently in individuals with the most severe motivational deficits. These findings point to an impairment in learning rate modulation in PSZ, leading to a reduced ability to adjust task behavior in response to unexpected outcomes. At the level of the brain, learning rate modulation deficits may be associated with decreased involvement of the dmPFC within a greater RL network.     

早产儿预防性应用抗生素的临床决策思路

近年来,随着对滥用抗生素所引起的细菌耐药性和二重感染的认识的逐步深入,预防性应用抗生素在临床上越来越受到限制.但由于早产儿感染的临床隐匿性和易并发严重并发症等特点,预防早产儿感染的发生和进一步的发展,就显得尤为重要.通过对早产儿发生感染的易感因素、感染诱因和临床特点的分析研究,来探讨早产儿临床预防应用抗生素的必要性、合理性及临床决策思路.     

Self-image of punk rock and nonpunk rock juvenile delinquents

The purpose of this study was to provide some understanding of punk rockers. Although they have received media attention in the depiction of their unusual hair and clothing styles, there is limited information about their personalities. In this study a delinquent group of punk rockers was compared with a delinquent group of nonpunk rockers on self-image, a personality factor related to teenagers' mental health and adjustment. Each group consisted of 20 subjects, 15 males and 5 females, aged 14 to 17. Subjects were administered a Screening Questionnaire, the Offer Self-Image Questionnaire (OSIQ), and the California Psychological Inventory (CPI) while detained at a Southern California juvenile hall. Interest in the CPI was focused on the Socialization (So) scale. A one-way analysis of variance was conducted on each of the five OSIQ dimensions. No significant differences were found between the groups. The importance of these findings is that even though punk rockers may look and act unusual, they may actually be similar to other groups. Due to possibly invalid CPI test protocols a t test and content analysis of the CPI So scale was conducted. The t test was significant and the chi-square analyses were significant on two questions of the CPI So scale. This suggests that there may be differences between the groups in terms of family dynamics. Professionals can utilize these findings in their work with this misunderstood segment of society.