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101.
Glucose effects on mecamylamine-induced memory deficits and decreases in locomotor activity in mice.
Peripheral glucose administration attenuates the effects of muscarinic cholinergic antagonists on several measures, including spontaneous alternation, inhibitory avoidance, and locomotor activity. The present study examined glucose interactions with mecamylamine, a nicotinic cholinergic antagonist, on these measures. Mecamylamine (5 mg/kg, sc) significantly impaired spontaneous alternation performance. Glucose (100 mg/kg, ip) administered with mecamylamine attenuated the impairment. Treatment with hexamethonium (5 and 10 mg/kg, sc), a peripheral nicotinic blocker, did not impair performance. Pretraining treatment with mecamylamine, but not hexamethonium, significantly reduced later retention latencies on inhibitory avoidance tests. Glucose, administered with mecamylamine prior to training, significantly attenuated the impaired test performance. Mecamylamine, but not hexamethonium, significantly decreased locomotor activity. In contrast to the attenuating effects of glucose on the other measures above, glucose administered with mecamylamine potentiated the decreased locomotor activity. These findings demonstrate that glucose influences the behavioral effects of a nicotinic cholinergic antagonist in a manner generally similar to that of muscarinic cholinergic antagonists, and supports previous evidence that circulating glucose interacts with central cholinergic functions. 相似文献
102.
E. Mark Gold 《Psychometrika》1973,38(4):555-569
The object of this paper is to clarify Schönemann's unfolding algorithm and, in particular, to make it clear that the equations numbered (3.2) in Schönemann's [1970] article, which define Schönemann's solutions, are not a complete set of restraints for the purpose of defining metric unfoldings. Namely, Schönemann has transformed the original equations which define an unfolding to a set of linear and non-linear equations of which he uses only the linear equations to define his solutions. Given infallible data (solution(s) exist) Schönemann's solutions will include the correct solutions. If enough data are available so that there are enough linear equations to uniquely determine a single solution, then Schönemann's solution will coincide with the correct solution. LetP andQ denote the number of elements in the two sets of points, the interset distances of which are specified by the data in the unfolding problem. Letm denote the dimensionality of the Euclidean space into which these points are to be imbedded. If only the linear equations, numbered (18) herein, are to be used, then Schönemann gives the following data requirement for the solution to be uniquely determined: Max {P – 1,Q – 1} m(m + 3)/2. If the full set of linear and nonlinear equations (18–20) are used, then the amount of data required for a solution to be locally unique is relaxed toP +Q – 1 m(m + 3)/2. Both of these results assume that the equations are independent, which has not been proved.This study was supported by General Research Support Grant RR 5612 of the Division of Research Facilities and Resources, National Institutes of Health, U.S. Public Health Service. 相似文献
103.
J M Gold 《Journal of personality assessment》1987,51(4):489-505
Traditional Rorschach theory has consistently overlooked the linguistic aspect of the response process. Most conceptualizations focus on the perceptual and cognitive aspects of the process, never examining the subject's need to find a linguistic representation for the inner, perceptual process. This review examines the traditional formulations and suggests that new research from information-processing, neuropsychological, and dual-coding memory theory paradigms offer new possibilities for Rorschach research that would incorporate an appreciation of the unique cognitive demand of the test--the linking of percept with language. 相似文献
104.
DasGupta S Fornari A Geer K Hahn L Kumar V Lee HJ Rubin S Gold M 《The Journal of medical humanities》2006,27(4):245-251
Although social justice is an integral component of medical professionalism, there is little discussion in medical education about how to teach it to future physicians. Using adult learning theory and the work of Brazilian educator Paulo Freire, medical educators can teach a socially-conscious professionalism through educational content and teaching strategies. Such teaching can model non-hierarchical relationships to learners, which can translate to their clinical interactions with patients. Freirian teaching can additionally foster professionalism in both teachers and learners by ensuring that they are involved citizens in their local, national and international communities. 相似文献
105.
Unrealistic optimism is often assessed using a single question asking for an estimate of comparative risk. However, it has been proposed that individuals treat such a question essentially as though it were only about their own risk. This proposal leads to the prediction that, when the questions about own risk and comparative risk are asked in sequence, the correlation between the resulting estimates should be lower if the question about own risk comes first than if the question about comparative risk comes first. This prediction was tested using a student sample (N=68). Participants answered the two types of question in sequence, with order of presentation being counterbalanced. Results were in accord with the prediction. Possible reasons are advanced for individuals' answering questions about comparative risk as if the questions concerned their own risk. 相似文献
106.
The most useful information about the anatomy of human memory comes from cases where there has been extensive neuropsychological testing followed by detailed post-mortem neurohistological analysis. To our knowledge, only eight such cases have been reported (four with medial temporal lobe damage and four with diencephalic damage). Here we present neuropsychological and post-mortem neurohistological findings for one patient (NC) with bilateral damage to the medial temporal lobe and two patients (MG, PN) with diencephalic damage due to bilateral thalamic infarction and Korsakoff's syndrome, respectively. All three patients exhibited a similar phenotype of amnesia with markedly impaired declarative memory (anterograde and retrograde) but normal performance on tests of nondeclarative memory (e.g., priming and adaptation-level effects) as well as on tests of other cognitive functions. Patient NC had damage to the hippocampus (dentate gyrus and the CA1 and CA3 fields) and layer III of the entorhinal cortex, but with relative sparing of the CA2 field and the subiculum. Patient MG had damage to the internal medullary lamina and mediodorsal thalamic nuclei. Patient PN had damage to the mammillary nuclei, mammillothalamic tracts, and the anterior thalamic nuclei. These findings illuminate several issues regarding the relation between diencephalic and medial temporal lobe amnesia, the status of recognition memory in amnesia, and the neuroanatomy of memory. 相似文献
107.
108.
The impact of haloperidol treatment on the Wechsler Adult Intelligence Scale (WAIS) and the Thought Disorder Index was investigated in a group of 19 patients with schizophrenia tested both before and after 26 days of treatment with haloperidol. Thought disorder scores declined significantly over the course of treatment and fewer patients demonstrated severe forms of thought disorder at the end of the trial. WAIS performance improved significantly but the magnitude of change was consistent with the literature on expected practice effects. Thought disorder scores were negatively correlated with IQ at baseline, but not at Day 26. The results suggest a partial dissociation of thought disorder and other cognitive functions in schizophrenia. 相似文献
109.
EQUATING INVERSE PROBABILITIES IN IMPLICIT PERSONALITY JUDGMENTS 总被引:1,自引:0,他引:1
Abstract— Meehl and Rosen (1955) observed that their colleagues tended to equate the sensitivity of a sign (its probability given a diagnostic category) with its predictive accuracy (the probability of the diagnostic category given the sign). Such equating of inverse probabilities implies ignoring base rates. Later, many researchers demonstrated such neglect in a number of experimental contexts involving hypothetical judgments; others have found some use of base rates—but only when base rates were supplied by the experimenter, in which case even irrelevant base rates influenced judgment. The present study tested for equating conditional probabilities in a context similar to the contexts involved in the initial observations—that is, subjects strove for accuracy rather than attempted to make good judgments about hypothetical problems, and the base rates were generated by the subjects themselves. Neglect of base rates was revealed by within-individual comparisons showing subjects equated inverse probabilities without equating the corresponding unconditional ones. 相似文献
110.
The problem-solving abilities of 4- and 5-year old children (N = 208) were assessed to test the hypothesis that high levels of compliance are negatively related to problem solving. Problem-solving competence was examined with a task-specific measure and a standardized measure of general problem-solving performance. Low compliant children performed better on both measures. The role of compliance in the cognitive development of girls and boys is discussed. 相似文献