Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo

We have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/ MAPK) is transiently activated in anatomically restricted regions of the lateral amygdala (LA) following Pavlovian fear conditioning and that blockade of ERK/MAPK activation in the LA impairs both fear memory consolidation and long-term potentiation (LTP) in the amygdala, in vitro. The present experiments evaluated the role of the ERK/MAPK signaling cascade in LTP at thalamo-LA input synapses, in vivo. We first show that ERK/MAPK is transiently activated/phosphorylated in the LA at 5 min, but not 15 or 60 min, after high-frequency, but not low-frequency, stimulation of the auditory thalamus. ERK activation induced by LTP-inducing stimulation was anatomically restricted to the same regions of the LA previously shown to exhibit ERK regulation following fear conditioning. We next show that intra-LA infusion of U0126, an inhibitor of ERK/MAPK activation, impairs LTP at thalamo-LA input synapses. Collectively, results demonstrate that ERK/MAPK activation is necessary for synaptic plasticity in anatomically defined regions of the LA, in vivo.     

A taxometric study of the Adult Attachment Interview

This study is the first to examine the latent structure of individual differences reflected in the Adult Attachment Interview (AAI; C. George, N. Kaplan, & M. Main, 1985), a commonly used and well-validated measure designed to assess an adult's current state of mind regarding childhood experiences with caregivers. P. E. Meehl's (1995) taxometric methods (i.e., MAXCOV-HITMAX) were applied to data from 504 AAIs. Analyses revealed that the variation underlying secure versus dismissing states of mind was more consistent with a dimensional than a taxonic model. (Taxometric analyses of preoccupation were indeterminate.) In addition, variation in secure adults' (n=278) reports about their early experiences revealed little evidence for qualitative groups of earned- and continuous-secures. Rather, the inferred life experiences of secure adults appeared to be distributed continuously. Findings are discussed in terms of their theoretical implications regarding the phenomenon of earned-security specifically and variation underlying secure and insecure states of mind more generally. The consequences of these analyses for AAI reliability training and coding are also explored.     

Effects of internet-based voucher reinforcement and a transdermal nicotine patch on cigarette smoking

Nicotine replacement products are commonly used to promote smoking cessation, but alternative and complementary methods may increase cessation rates. The current experiment compared the short-term effects of a transdermal nicotine patch to voucher-based reinforcement of smoking abstinence on cigarette smoking. Fourteen heavy smokers (7 men and 7 women) completed the four 5-day phases of the study: baseline, patch treatment, voucher treatment, and return to baseline. The order of the two treatment phases was counterbalanced across participants. In the patch treatment condition, participants wore a 14-mg transdermal nicotine patch every day. In the voucher treatment condition, participants received vouchers contingent on abstinence from smoking, defined as producing carbon monoxide (CO) readings of < or =4 parts per million. Participants e-mailed two video clips per day showing them breathing into a CO monitor and the resulting CO reading to clinic staff. In the voucher treatment, 24% of samples were negative, and 5% of samples were negative in the patch treatment. Results suggest that contingent vouchers were more effective than transdermal nicotine patches in promoting abstinence.     

A model of the synchronic self

The phenomenology of the self includes the sense of control over one's body and mind, of being bounded in body and mind, of having perspective from within one's body and mind and of being extended in time. I argue that this phenomenology is to be accounted for by a set of five dissociable cognitive capacities that compose the self. The focus of this paper is on the four capacities that compose the synchronic self: the agentive(B) self, which underlies the sense of control over one's body; the boundary(B) self, which underlies the sense of being bounded within one's body; the agentive(M) self which underlies the sense of control over one's thoughts; and the boundary(M) self which underlies the sense of being bounded within one's mind. I model the agentive(B) and agentive(M) selves as parts of the motor control system and the boundary(B) self as the capacity to form and integrated map of the body. I point to the delusion of thought broadcast as a possible source of evidence for future research on the boundary(M) self.     

Predicting institutional adjustment with the Lifestyle Criminality Screening Form and the Antisocial Features and Aggression scales of the PAI

I included scores on the Antisocial Features (ANT) and Aggression (AGG) scales of the Personality Assessment Inventory (PAI; Morey, 1991) and ratings on the Lifestyle Criminality Screening Form (LCSF; Walters, White, & Denney, 1991) along with age and prior disciplinary record in a series of negative binomial regression analyses of total, nonaggressive, and aggressive incident reports (IRs) received in a 2-year follow-up of 120 male maximum security federal prisoners. Findings indicated that the AGG scale, but not the LCSF or ANT, predicted total and nonaggressive IR counts. The LCSF achieved significant receiver operating characteristic (ROC) results in predicting dichotomized aggressive IRs, the ANT achieved significant ROC results in predicting dichotomized total and nonaggressive IRs, and the AGG achieved significant ROC results in predicting all 3 dichotomized categories of IR. Supplemental analyses revealed that the AGG continued to predict total and nonaggressive IRs when the Psychological Inventory of Criminal Thinking Styles (PICTS; Walters, 1995) Proactive scale was included in the negative binomial regression but not when the PICTS Reactive scale was included in the negative binomial regression.     

The Adult Attachment Interview and self-reports of attachment style: an empirical rapprochement

Although 10 studies have been published on the empirical overlap of the Adult Attachment Interview (AAI) and measures of self-reported attachment style, results in this literature have been inconsistently interpreted in narrative reviews. This report was designed as a rapprochement of the AAI and attachment style literatures and includes 3 studies. Study 1 (combined N = 961) is a meta-analytic review showing that by J. Cohen's (1992) criteria (mean r = .09), the association between AAI security and attachment style dimensions is trivial to small. Study 2 (N = 160) confirms meta-analytic results with state-of-the-art assessments of attachment security and also examines attachment dimensions in relation to the Big 5 personality traits. Finally, Study 3 is an investigation of 50 engaged couples that shows that developmental and social psychological measures of attachment security predict somewhat distinct--though theoretically anticipated--aspects of functioning in adult relationships.     

Factors in the assessment of suicidality in youth

Suicide remains a leading cause of death among youth, and suicide ideation and behavior are relatively common in both normal and clinical populations. Clinicians working with young people must assess for the presence of suicidal ideation, suicidal behavior, and other risk factors, in order to determine the level of risk. This paper provides the clinician with a summary of risk factors for youth suicide, as well as providing standardized terminology to enhance assessment of suicidal ideation and behavior.     

Rawls and Religious Community: Ethical Decision Making in the Public Square

While most people may initially agree that justice is fairness,as an evangelical Protestant I argue that, for many religiouscomprehensive doctrines, the Rawlsean model does not possessthe resources necessary to sustain tolerance in moral decisionmaking. The weakness of Rawls's model centers on the reasonablepriority of convictions that arise from private comprehensivedoctrines. To attain a free and pluralistic society, peopleneed resources sufficient to provide reasons to tolerate actionsthat are otherwise intolerable. In addition to arguing for thedeficiency of the Rawlsean political model, I sketch out a preliminarymodel of ambassadorship that offers religious communities, andin particular Protestant evangelicals, the necessary resourcesto engage the broader society tolerantly while maintaining theirreligious convictions. As a citizen of the church and a memberof another kingdom, Christians serve as ambassadors to thosewho are not of the heavenly kingdom. I take this model to bemore ambitious than that of a sojourner who lives in the landbut is isolated as much as possible from society, while moremodest than that of reconstructionists who seek to implementtheir own sacred law on all others.