Autobiographical memories and views of the future: In relation to dysphoria

The present study investigated dysphoric individuals' self‐referential processing of autobiographical memories and future personal events, in relation to specificity and response latency. Dysphoric individuals (n  =  17) and nondysphoric controls (n  =  17) were selected from a larger sample based on self‐reported depression. Participants completed an autobiographical memory task (AMT) and a future event task (FET), using pleasant and unpleasant (anxiety‐relevant, depression‐relevant) emotional word cues. In response to each emotional cue, participants were required to access and write down a specific personal memory and future event, respectively. Consistent with the hypotheses, dysphoric individuals were less specific in describing pleasant and unpleasant experiences (particularly pleasant), irrespective of time condition. As expected, dysphoric individuals' specificity for distinct depression‐relevant and anxiety‐relevant experiences did not differ significantly. As predicted, all participants were less specific in describing future personal events than in recalling personal memories. As predicted, dysphoric individuals took longer to think of pleasant memories and pleasant future experiences than controls but, as expected, groups did not differ significantly on mean reaction times for past and future unpleasant experiences. Overall, the data showed a degree of consistency in participants' past and future‐oriented processing of self‐referential material. Although considerable research has investigated autobiographical memories in relation to emotional disturbance, the present findings suggest that constructing future emotional experiences is also an important aspect of mental health.     

Effect of accent and dialect on employability

This study was designed to determine how ethnicity, the amount of perceived accent or dialect, and comprehensibility affect a speaker's employability. Sixty human resource specialists judged 3 female potential applicants. The applicants represented speakers of Spanish‐influenced English, Asian‐influenced English, and African American Vernacular English. When the speaker's perceived accent or dialect was minimal, perceived ethnicity did not affect employability. However, all speakers with maximally perceived accents or dialects were given a lower employability rating. Thus, speakers with a maximally perceived accent or dialect should consider accent or dialectal modification if their comprehensibility or prospective employability is compromised.     

No representation without awareness in the lateral occipital cortex

Recent research has shown that four small dots presented in the vicinity of, but not adjacent to, a target stimulus can banish that stimulus from conscious awareness. It is thought that the mental representation of the masked stimulus is "erased" by the trailing quartet of dots. Using functional magnetic resonance adaptation, we show that there is no persisting neural representation of the successfully masked stimulus in lateral occipital cortex, a region that has been implicated in the processing of object structure. This finding rules out the alternative interpretation that a lingering neural representation is merely rendered inaccessible to consciousness, as is the fate, for example, of monocular information under conditions of binocular rivalry.     

Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor

Since the brain neurotransmitter changes characterising panic disorder remain uncertain, we quantified brain noradrenaline and serotonin turnover in patients with panic disorder, in the absence of a panic attack. Thirty-four untreated patients with panic disorder and 24 matched healthy volunteers were studied. A novel method utilising internal jugular venous sampling, with thermodilution measurement of jugular blood flow, was used to directly quantify brain monoamine turnover, by measuring the overflow of noradrenaline and serotonin metabolites from the brain. Radiographic depiction of brain venous sinuses allowed differential venous sampling from cortical and subcortical regions. The relation of brain serotonin turnover to serotonin transporter genotype and panic disorder severity were evaluated, and the influence of an SSRI drug, citalopram, on serotonin turnover investigated. Brain noradrenaline turnover in panic disorder patients was similar to that in healthy subjects. In contrast, brain serotonin turnover, estimated from jugular venous overflow of the metabolite, 5-hydroxyindole acetic acid, was increased approximately 4-fold in subcortical brain regions and in the cerebral cortex (P < 0.01). Serotonin turnover was highest in patients with the most severe disease, was unrelated to serotonin transporter genotype, and was reduced by citalopram (P < 0.01). Normal brain noradrenaline turnover in panic disorder patients argues against primary importance of the locus coeruleus in this condition. The marked increase in serotonin turnover, in the absence of a panic attack, possibly represents an important underlying neurotransmitter substrate for the disorder, although this point remains uncertain. Support for this interpretation comes from the direct relationship which existed between serotonin turnover and illness severity, and the finding that SSRI administration reduced serotonin turnover. Serotonin transporter genotyping suggested that increased whole brain serotonin turnover most likely derived not from impaired serotonin reuptake, but from increased firing in serotonergic midbrain raphe neurons projecting to both subcortical brain regions and the cerebral cortex.     

Attitudes Toward Fragile X Mutation Carrier Testing from Women Identified in a General Population Survey

Fragile X syndrome is primarily due to a CGG repeat expansion found in the FMR1 X-linked gene. In a previous study, we conducted focus groups with women to assess their attitudes towards fragile X carrier screening. In this follow-up study, we conducted in-depth interviews of general population reproductive-age women who were identified as carriers. We explored their attitudes toward testing for carrier status of the fragile X mutation. These women underwent screening primarily to participate in a research project rather than in search of a diagnosis for specific symptoms. As such, these women were wholly unprepared for positive carrier results. Their responses about their results and carrier screening, in many cases, were being worked out over the course of the interview itself. The most salient finding of this work is the apparent lack of relevance of carrier status to these women. Many expressed that although the information could be relevant in the future, it is not relevant at this stage of their lives in terms of family planning (either with respect to having unaffected offspring or to premature ovarian failure) and personal relationships. Although issues of abortion seemed prominent in the focus groups, we found that carrier status did not have an apparent effect on women’s attitudes about termination. We hypothesize this may be related to the fact that women had not processed their new carrier status and had not related it to previously-formed personal opinions. The findings of this work have significant implications for genetic counseling and population screening. Genetic counselors should be mindful that general population women may not recognize the immediate importance of their carrier status even when literature is provided and discussed prior to providing a sample. As part of comprehensive genetic counseling, counselors should identify the reproductive life stage of the woman receiving the new information and help her identify when this information would be more meaningful in her life. Counselors can assist in setting up a personalized road map with specific types of services that will be more applicable to the woman as her carrier status becomes more relevant.     

Information structure expectations in sentence comprehension

In English, new information typically appears late in the sentence, as does primary accent. Because of this tendency, perceivers might expect the final constituent or constituents of a sentence to contain informational focus. This expectation should in turn affect how they comprehend focus-sensitive constructions such as ellipsis sentences. Results from four experiments on sluicing sentences (e.g., The mobster implicated the thug, but we can't find out who else) suggest that perceivers do prefer to place focus late in the sentence, though that preference can be mitigated by prosodic information (pitch accents, Experiment 2) or syntactic information (clefted sentences, Experiment 3) indicating that focus is located elsewhere. Furthermore, it is not necessarily the direct object, but the informationally focused constituent that is the preferred antecedent (Experiment 4). Expectations regarding the information structure of a sentence, which are only partly cancellable by means of overt focus markers, may explain persistent biases in ellipsis resolution.     

Nonlocal effects of prosodic boundaries

Placing a prosodic boundary before a phrase may influence its syntactic analysis. However, the boundary’s effect depends on the presence, size, and position of other, earlier, prosodic boundaries. In three experiments, we extend previous results about the effect of the position of the early boundary. In sentences in which a final phrase may modify either a local verb or an earlier verb, a boundary immediately after the first verb leads to more first-verb attachments than when the earlier boundary appears in another position between the two verbs (Experiments 1 and 2). This effect cannot be attributed to weaker effects of more distant boundaries (Experiment 2), but is likely due to the first verb being more prominent when a boundary immediately follows it, since similar effects are observed when the verb is accented (Experiment 3). The results support the informative boundary hypothesis and show that the impact of earlier, nonlocal boundaries is not fully uniform.     

Using the MMPI-2 to Predict Symptom Reduction During Psychotherapy in a Sample of Community Outpatients

In the present study, potential MMPI-2 predictors of psychotherapy outcome were examined in a community clinical sample of 51 patients seeking treatment at a university training clinic. Results indicated that particular MMPI-2 scales (L, F, Pd, Pa, Sc, Trt) were the most predictive of initial levels of patient distress, whereas three other clinical scales (Hs, D, Hy) were significantly associated with actual symptom reduction over time. The clinical implications of these data include the use of the MMPI-2 in clinical practice as a means to frame the provision of direct feedback to patients regarding the likelihood of treatment response, which in turn, might actually have therapeutic benefits. The limitations of the study are reviewed and suggestions for future research are offered, including the potential use of widely known and utilized instruments in helping to predict response to psychotherapy.     

On becoming a psychoanalyst

One has the opportunity and responsibility to become an analyst in one's own terms in the course of the years of practice that follow the completion of formal analytic training. The authors discuss their understanding of some of the maturational experiences that have contributed to their becoming analysts in their own terms. They believe that the most important element in the process of their maturation as analysts has been the development of the capacity to make use of what is unique and idiosyncratic to each of them; each, when at his best, conducts himself as an analyst in a way that reflects his own analytic style; his own way of being with, and talking with, his patients; his own form of the practice of psychoanalysis. The types of maturational experiences that the authors examine include situations in which they have learned to listen to themselves speak with their patients and, in so doing, begin to develop a voice of their own; experiences of growth that have occurred in the context of presenting clinical material to a consultant; making self-analytic use of their experience with their patients; creating/discovering themselves as analysts in the experience of analytic writing (with particular attention paid to the maturational experience involved in writing the current paper); and responding to a need to keep changing, to be original in their thinking and behavior as analysts.     

CONSTRUCTING AND DERIVING RECIPROCAL TRIGONOMETRIC RELATIONS: A FUNCTIONAL ANALYTIC APPROACH

Participants were pretrained and tested on mutually entailed trigonometric relations and combinatorially entailed relations as they pertained to positive and negative forms of sine, cosine, secant, and cosecant. Experiment 1 focused on training and testing transformations of these mathematical functions in terms of amplitude and frequency followed by tests of novel relations. Experiment 2 addressed training in accordance with frames of coordination (same as) and frames of opposition (reciprocal of) followed by more tests of novel relations. All assessments of derived and novel formula‐to‐graph relations, including reciprocal functions with diversified amplitude and frequency transformations, indicated that all 4 participants demonstrated substantial improvement in their ability to identify increasingly complex trigonometric formula‐to‐graph relations pertaining to same as and reciprocal of to establish mathematically complex repertoires.