Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis

Computerized treadmill gait analysis in models of toxicant exposure and neurodegenerative disorders holds much potential for detection and therapeutic intervention in these models, and researchers must validate the technology that assists in that data collection and analysis. The present authors used a commercially available computerized gait analysis system that used (a) a motorized treadmill on retired breeder male C57BL/6J mice, (b) the toxicant-induced (1-methyl-1-, 2-, 3-, 6-tetrahydropyridine) MPTP mouse model of Parkinson's disease (PD), and (c) the superoxide dismutase 1 (SOD1) G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS). The authors compared the detection of deficits by computerized treadmill gait analysis in MPTP-treated mice with inked-paw stride length and correlated these measures to dopamine (DA) loss. The authors found that the computerized treadmill gait analysis system did not distinguish MPTP-treated mice from vehicle controls, despite a nearly 90% deficit of striatal DA. In contrast, decreases in inked-paw stride length correlated strongly with DA losses in these same animals. Computerized treadmill gait analysis could neither reliably distinguish SOD1 G93A mutant mice from controls from 6 to 12 weeks of age nor detect any consistent early motor deficits in these mice. On the basis of the authors' findings, they inferred that computerized gait analysis on a motorized treadmill is not suited to measuring motor deficits in either the MPTP mouse model of PD or the SOD1 G93A mouse model of ALS.     

Knowledge cannot explain the developmental growth of working memory capacity

According to some views of cognitive growth, the development of working memory capacity can account for increases in the complexity of cognition. It has been difficult to ascertain, though, that there actually is developmental growth in capacity that cannot be attributed to other developing factors. Here we assess the role of item familiarity. We document developmental increases in working memory for visual arrays of English letters versus unfamiliar characters. Although letter knowledge played a special role in development between the ages of 6 and 8 years, children with adequate letter knowledge showed practically the same developmental growth in normalized functions for letters and unfamiliar characters. The results contribute to a growing body of evidence that the developmental improvement in working memory does not wholly stem from supporting processes such as encoding, mnemonic strategies, and knowledge. A video abstract is available at: https://www.youtube.com/watch?v=LJdqErLR2Hs&feature=youtu.be     

LeRoy Walters and Julie Gage Palmer,The Ethics of Human Gene Therapy

Theoretical Medicine and Bioethics -     

Executive-process interactive control: A unified computational theory for answering 20 questions (and more) about cognitive ageing

Although the effects of ageing on human information processing and performance have been studied extensively, many fundamental questions about cognitive ageing remain to be answered definitively. For example, what are the sources of age-related slowing? How much is working-memory capacity reduced in older adults? Is time-sharing ability lost with age? Answering such questions requires a unified computational theory that characterises the interactive operations of many component mental processes and integrates diverse data on cognitive ageing. Toward fulfilling this requirement, an executive-process interactive control (EPIC) architecture has been extended to model performance of both young and older adults. EPIC models yield accurate accounts of ageing effects on reaction times and accuracy in basic dual-task and working-memory paradigms. From these accounts, it appears that time-sharing ability and working-memory capacity decrease relatively little until after 70 years of age. Before age 70, at least some apparent performance decrements may be attributable to conservative executive processes and inefficient task procedures rather than decreased "hardware" functionality. By clarifying and deepening such insights, unified computational theories like EPIC will help answer many questions about cognitive ageing.     

The Effect of a Final Exam on Long-Term Retention

Testing on a final exam in a college course improved long-term retention over material that had not been tested on the final. Students from an upper level psychology course took a long-term retention test, four to five months after the end of the course. For half of the items, a related question had been on the final. For the remaining half, a related question had appeared on an earlier exam, but not the final. On the long-term retention test, percent correct was 79% when a related question had appeared on the final and 67% when a related question had not appeared on the final. These results have both theoretical and practical implications.     

Interdisciplinary Linkage of Community Psychology and Cross-Cultural Psychology: History, Values, and an Illustrative Research and Action Project on Intimate Partner Violence

An analysis of the respective organizational histories, missions, and scholarly activity of the International Association for Cross-Cultural Psychology and the Society for Community Research and Action was conducted in order to inform the development of interdisciplinary linkages between members of the two organizations. The analysis revealed many points of shared values and actions, as well as some important differences. Both scholarly organizations developed out of a similar historical and cultural zeitgeist in the late 1960s and early 1970s. The missions emphasize the role of culture/diversity in psychological phenomena, adopting an interdisciplinary orientation, the value of collaboration, the importance of research method and ethics, and the value of action research. However, community psychology generally lacks an adequate treatment of cultural phenomena while cross-cultural psychology often fails to draw on community and participatory methods useful for understanding culture in context. These common roots and differences are examined. Finally, we describe a community based, participatory research and intervention project to address intimate partner violence among Latinos and European-Americans living in Oregon. Analysis of the research process and on some of our initial findings illustrates challenges and potential benefits of an interdisciplinary, cultural community psychology.     

Online counselling: a descriptive analysis of therapy services on the Internet

This study investigated the emerging practice of online counselling. Although the traditional practice of counselling involves face-to-face interaction between counsellor and client, a growing number of practitioners are providing counselling or therapy services via the Internet. In the present study, a total of 67 online counsellors completed a questionnaire exploring the backgrounds, services, fees, and communication technologies of practitioners offering online counselling to the public. Results suggest that online counselling is conducted by relatively experienced, primarily Western-based practitioners and is characterised by the use of email. Online clients are mainly female and receive relatively short-term interventions. Although the field appears to be evolving as its popularity increases, some ethical concerns raised by early research remain inadequately addressed.