The Problem with Token-reflexivity

This essay presents an argument against the token-reflexive approach to the semantics for indexical languages. After some preliminary remarks in section one, sections two and three explain why some traditional arguments against token-reflexivity are ultimately ineffective. Section four puts forth a more persuasive argument, to the effect that token-reflexive views overgenerate with respect to results of analyticity. However, as section five explains, defenders of the alternative, type-oriented view have all too often wasted the advantage offered by their approach: the unmotivated, independent restriction of semantic evaluation to so-called ‘proper’ indexes is responsible for undesirable conclusions, similar to those to which token- reflexive theorists are committed.     

Workaholism and work engagement: how are they similar? How are they different? A systematic review and meta-analysis

Workaholism and work engagement can be depicted, respectively, as the pathological and the healthy form of heavy work investment. In spite of their different definitions and outcomes on individual and organizational life, workaholism and work engagement are not clearly and adequately distinguished by scholars and researchers as they appear to show some overlapping features. The aim of this investigation was to meta-analyze available studies, selected by systematic review, on the relations between subdimensions of workaholism and work engagement. Thirty-five studies were eligible for analysis. Associations emerged between Working Excessively and Absorption (g = .34), Working Compulsively and Absorption (g = .28), and Working Excessively and Dedication (g = .14). Moreover, the results were not influenced by publication bias and showed nationality to be a significant moderator. Overall, these findings suggest that further research is necessary to extend our knowledge of workaholism, work engagement, and the relationship between the two, in order to disentangle commonalities and differences between them.     

Scientific Integrity Principles and Best Practices: Recommendations from a Scientific Integrity Consortium

Science and Engineering Ethics - A Scientific Integrity Consortium developed a set of recommended principles and best practices that can be used broadly across scientific disciplines as a mechanism...     

On a Generalization of Local Independence in Item Response Theory Based on Knowledge Space Theory

Psychometrika - Knowledge space theory (KST) structures are introduced within item response theory (IRT) as a possible way to model local dependence between items. The aim of this paper is...     

Conflict of interest as seen from a researcher's perspective

The continuous growth of the pharmaceutical industry is expected to require a considerable output of new drugs, with speedy development and approval processes. This profit-driven expansion of the drug market may broaden the already established erosion of the role of academia in favor of commercial clinical research organizations. Less and less control on the clinical trial design, its conduct and the resulting publication[s] is the likely consequence. Academic medicine and governments should find means to sustain the development of independent clinical research. An earlier version of this paper was presented at an International Conference on “Conflict of Interest and its Significance in Science and Medicine” held in Warsaw, Poland on 5–6 April, 2002.     

Prospects for gene therapy in the fragile X syndrome

"If politics is the art of the possible, research is the art of the soluble. Both are immensely practical-minded affairs." P. B. Medawar.Gene therapy is unarguably the definitive way to treat, and possibly cure, genetic diseases. A straightforward concept in theory, in practice it has proven difficult to realize, even when directed to easily accessed somatic cell systems. Gene therapy for diseases in which the central nervous system (CNS) is the target organ presents even greater challenges and diverse vectors and brain delivery approaches are under investigation. We argue that in the case of the fragile X syndrome the approach most likely to have a chance of being effective should consist of a small, diffusible vector derived from the adeno-associated virus, carrying an FMR1 cDNA comprising the 5' promoter region and the 3' untranslated region of the gene, delivered to the entire brain by osmotic blood-brain barrier disruption. The approach can be tested in Fmr1 knockout mice, although changes in their neurobehavioral abnormalities may be difficult to evaluate. A defect in the expression of GABA(A) receptors in these mice-if shown to be a direct consequence of the Fmr1 defect-promises to be a more readily assessable marker of restored FMRp function on gene transfer.     

Orienting of attention via observed eye gaze is head-centred

Observing averted eye gaze results in the automatic allocation of attention to the gazed-at location. The role of the orientation of the face that produces the gaze cue was investigated. The eyes in the face could look left or right in a head-centred frame, but the face itself could be oriented 90 degrees clockwise or anticlockwise such that the eyes were gazing up or down. Significant cueing effects to targets presented to the left or right of the screen were found in these head orientation conditions. This suggests that attention was directed to the side to which the eyes would have been looking towards, had the face been presented upright. This finding provides evidence that head orientation can affect gaze following, even when the head orientation alone is not a social cue. It also shows that the mechanism responsible for the allocation of attention following a gaze cue can be influenced by intrinsic object-based (i.e. head-centred) properties of the task-irrelevant cue.     

Adjectives Modulate Sensorimotor Activation Driven by Nouns

We performed three experiments to investigate whether adjectives can modulate the sensorimotor activation elicited by nouns. In Experiment 1, nouns of graspable objects were used as stimuli. Participants had to decide if each noun referred to a natural or artifact, by performing either a precision or a power reach-to-grasp movement. Response grasp could be compatible or incompatible with the grasp typically used to manipulate the objects to which the nouns referred. The results revealed faster reaction times (RTs) in compatible than in incompatible trials. In Experiment 2, the nouns were combined with adjectives expressing either disadvantageous information about object graspability (e.g., sharp) or information about object color (e.g., reddish). No difference in RTs between compatible and incompatible conditions was found when disadvantageous adjectives were used. Conversely, a compatibility effect occurred when color adjectives were combined with nouns referring to natural objects. Finally, in Experiment 3 the nouns were combined with adjectives expressing tactile or shape proprieties of the objects (e.g., long or smooth). Results revealed faster RTs in compatible than in incompatible condition for both noun categories. Taken together, our findings suggest that adjectives can shape the sensorimotor activation elicited by nouns of graspable objects, highlighting that language simulation goes beyond the single-word level.     

Experiencing,caring, coping: Vested interest mediates the effect of past experience on coping behaviors in environmental risk contexts

Social psychology provides a treasure-trove of insights into adaptations that may limit the devastating effects of climate change. Vested Interest Theory may contribute to this knowledge base, suggesting that one's vested interest may significantly influence appropriate coping behaviors, as it is has been shown to enhance the relation between attitudes and self-relevant behaviors. The theory's utility is investigated in an environmental risk context. Here, we replicate previous research findings showing that citizens in high-risk areas perceived higher risk and stronger intentions to cope with it when vested interest perceptions were salient. Furthermore, the current studies investigate the behavioral effect of vested interest on coping with an environmental risk (flooding): results showed that vested interest significantly mediated the past experience–coping behaviors relationship. In Study 1’s mediation analysis (Rome and Vibo Valentia, Italy, N = 466), past experience of flood risk enhanced vested interest in flood risk, which in turn increased volunteering for flood prevention activities, thereby mitigating risk. In Study 2 (N = 391), the same mediation effect was replicated in the Timis region, a high flood risk area in western Romania. These results shed light on literature inconsistencies on this topic, providing insights for the theoretical understanding of the relationship between past experience of a given risk and related coping behaviors, possibly shedding light to the risk perception paradox. These insights may drive effective intervention strategies to enhance people's behavioral coping with environmental risks.