Brain Oxidative Damage Following Acute Immobilization and Mild Emotional Stress

We studied the role of free radicals on brain oxidative damage in rats after acute immobilization stress (restraint) and mild emotional stress (handling). To investigate brain oxidative damage, CuZn and Mn dependent superoxide dismutase (CuZn SOD, Mn SOD) activities, lipid peroxidation (TBARs), Na ⁺ K ⁺ ATPase activity, protein carbonyl (PrC), and reduced and oxidized glutathione (GSH, GSSG) levels were measured in the cerebral cortex (CTX), hippocampus (HIP), and striatum (ST) of the animals after the two different stress stimuli. Because stress produces abnormalities in the hypothalamic-pituitary-adrenal axis, the intensity of the two stress conditions were measured by plasmatic corticosteroid (COR) levels: particularly, COR levels doubled in handled rats and increased 15-fold in restrained animals. The SOD activities increased in CTX and decreased in HIP of the handled rats, while in ST a significant decrease in handled animals but an increase in restrained animals occurred. TBARs, GSH, and GSSG levels remained unchanged, while an index of glutathione redox decreased significantly in ST of handled animals and in CTX of restrained ones. Na ⁺ K ⁺ ATPase activity increased significantly in the HIP and ST of both groups of stressed rats. The stress induced a remarkable increase in PrC levels in all studied cerebral areas. These findings provide evidence to support the idea that stress produces oxidants but that the oxidative damage in stress differs in cerebral areas and could contribute to the degenerative mechanism of aging.     

Altered Cortico-Limbic Functional Connectivity During an Empathy Task in Subjects with Post-Traumatic Stress Disorder

Empathy is a multidimensional construct consisting of cognitive (inferring mental states) and emotional (empathic concern) components. Emotional empathy is severely impaired in individuals affected by Post-Traumatic Stress Disorder (PTSD). Here, we investigated the neural correlates of such an emotional empathy dysfunction to shed light on the neural circuitry responsible for the social and emotional dysfunction in PTSD. We asked a group of PTSD and a group of healthy controls to solve a Multifaceted Empathy Test, measuring both cognitive and emotional empathy, and investigated the functional connectivity of the cortical areas involved in solving the test. The results revealed that, in healthy individuals, increased neural activity in the frontal cortex modulates activity in the insula while subjects perform the emotional empathy task; whereas, in individuals affected by PTSD, increased activity in limbic regions such the insula and the amygdala modulates activity in the frontal cortex while performing the emotional empathy task. These findings suggest that the lack of cortical top-down control of the frontal cortex on the limbic system in PTSD during empathic processing may explain the emotional and social difficulties experienced by individuals suffering from PTSD.     

A Computationally Grounded,Weighted Doxastic Logic

Modelling, reasoning and verifying complex situations involving a system of agents is crucial in all phases of the development of a number of safety-critical systems. In particular, it is of fundamental importance to have tools and techniques to reason about the doxastic and epistemic states of agents, to make sure that the agents behave as intended. In this paper we introduce a computationally grounded logic called COGWED and we present two types of semantics that support a range of practical situations. We provide model checking algorithms, complexity characterisations and a prototype implementation. We validate our proposal against a case study from the avionic domain: we assess and verify the situational awareness of pilots flying an aircraft with several automated components in off-nominal conditions.     

Assessing risky public investments with MUSTARD

This paper presents a practical implementation of multicriteria methodologies based on the UTA model by Jacquet‐Lagrèze and Siskos and Quasi‐UTA model by Beuthe and Scannella, which are specified with a non‐linear, but piecewise linear, additive utility function. In contrast with the general UTA model, the Quasi‐UTA specification structures the partial utilities as recursive exponential functions of only one curvature parameter. This allows for a reduction of the quantity of information necessary to build the utility function. The software MUSTARD implements different variants of these models. Firstly, it offers the basic deterministic UTA model of disaggregation, but also its first programmed stochastic version. In both cases, the software proceeds stepwise and interactively helping the decision maker to formulate the problem and state preferences between projects; in the stochastic case, the decision maker is even helped to build the criteria distributions. The Quasi‐UTA specification can be introduced in this disaggregation model. Secondly, the software offers an aggregation model whereby the Quasi‐UTA partial utility functions are built separately through specific questioning processes. The questions relating to deterministic criteria are of the ‘direct rating type’, while those of the stochastic criteria are either of the ‘variable probability’ or the ‘variable outcome’ type. The criteria weights can be assessed by the ‘swing weight’ method or by a UTA‐II side‐program. As an example as well as a test of the Quasi‐UTA aggregation approach, the paper presents its application to a real problem of selecting road investment projects in Belgium. Several experts and civil servants were interviewed, and their individual utility functions derived. The projects are ranked according to their rate of return, which is computed on the basis of the projects certain equivalent money value. Copyright © 2002 John Wiley & Sons, Ltd.     

Assessing clergy work-related psychological health: reliability and validity of the Francis Burnout Inventory

ABSTRACT

Drawing on the classic model of balanced affect, the Francis Burnout Inventory (FBI) conceptualised good work-related psychological health among clergy in terms of negative affect being balanced by positive affect. In the FBI negative affect is assessed by the Scale of Emotional Exhaustion in Ministry (SEEM) and positive affect is assessed by the Satisfaction in Ministry Scale (SIMS). In support of the idea of balanced affect, previous work had shown a significant interaction between the effects of SEEM and SIMS scores, showing that the mitigating effects of positive affect on burnout increased with increasing levels of negative affect. In this paper a convenience sample of 155 priests serving with the Roman Catholic Church in Italy have been assessed on the Purpose in Life Scale (PILS) as an independent measure of well-being and concurrently on the two scales, SEEM and SIMS. Crucially for confirming the idea of balanced affect, there was a significant interaction between the effects of SEEM and SIMS scores on scores recorded on the PILS, confirming that the mitigating effects of satisfaction in ministry on purpose increased with increasing levels of emotional exhaustion.     

Development of Metaphorical Thought before Language: the Pragmatic Construction of Metaphors in Action

In this article, we set out, first, a general overview of metaphor and metaphorical thought research within cognitive psychology and developmental psychology. We claim that, although research efforts broadened perspectives that considered metaphors to be ornaments of poetic language, certain predominance of a linguistic point of view within investigations led to relatively little attention paid to (i) non-verbal and non-written metaphorical instantiations, and (ii) the pre-linguistic and cultural origins of metaphorical thought. Next, we attempt to delve into, and model, the ontogenetic origins of metaphor, taking into consideration social and cultural elements. To that end, we consider the Vygotskian perspective and contemporary research from the pragmatics of the object. We propose that metaphorical thought is an emerging result of a complex web of dynamic relationships between pre-linguistic and socioculturally regulated semiotic systems. The analysis undertaken shows the need for a research programme with a developmental orientation that considers metaphor to be a product of the intertwining between the individual and social dimensions of cognitive development. We suggest this programme should find its roots in the analysis of the semiotic skills that precede the acquisition of metaphorical language.     

To know you is to love you: Effects of intergroup contact and knowledge on intergroup anxiety and prejudice among indigenous Chileans

Two surveys were conducted in Chile with indigenous Mapuche participants (N study 1: 573; N study 2: 198). In line with previous theorising, it was predicted that intergroup contact with the non‐indigenous majority reduces prejudice. It was expected that this effect would be because of contact leading to more knowledge about the outgroup, which would then lead to less intergroup anxiety. The two studies yielded converging support for these predictions.     

Sex differences in eye gaze and symbolic cueing of attention.

Observing a face with averted eyes results in a reflexive shift of attention to the gazed-at location. Here we present results that show that this effect is weaker in males than in females (Experiment 1). This result is predicted by the 'extreme male brain' theory of autism (Baron-Cohen, 2003), which suggests that males in the normal population should display more autism-like traits than females (e.g., poor joint attention). Indeed, participants' scores on the Autism-Spectrum Quotient (Baron-Cohen, Wheelwright, Stott, Bolton, & Goodyear, 2001) negatively correlated with cueing magnitude. Furthermore, exogenous orienting did not differ between the sexes in two peripheral cueing experiments (Experiments 2a and 2b). However, a final experiment showed that using nonpredictive arrows instead of eyes as a central cue also revealed a large gender difference. This demonstrates that reduced orienting from central cues in males generalizes beyond gaze cues. These results show that while peripheral cueing is equivalent in the male and female brains, the attention systems of the two sexes treat noninformative symbolic cues very differently.