Extinction partially reverts structural changes associated with remote fear memory

Structural synaptic changes occur in medial prefrontal cortex circuits during remote memory formation. Whether extinction reverts or further reshapes these circuits is, however, unknown. Here we show that the number and the size of spines were enhanced in anterior cingulate (aCC) and infralimbic (ILC) cortices 36 d following contextual fear conditioning. Upon extinction, aCC spine density returned to baseline, but the enhanced proportion of large spines did not. Differently, ILC spine density remained elevated, but the size of spines decreased dramatically. Thus, extinction partially erases the remote memory network, suggesting that the preserved network properties might sustain reactivation of extinguished conditioned fear.     

A "unity assumption" does not promote intersensory integration

An account of intersensory integration is premised on knowing that different sensory inputs arise from the same object. Could, however, the combination of the inputs be impaired although the "unity assumption" holds? Forty observers viewed a square through a minifying (50%) lens while they simultaneously touched the square. Half could see and half could not see their haptic explorations of the square. Both groups, however, had reason to believe that they were touching and viewing the same square. Subsequent matches of the inspected square were mutually biased by touch and vision when the exploratory movements were visible. However, the matches were biased in the direction of the square's haptic size when observers could not see their exploratory movements. This impaired integration without the visible haptic explorations suggests that the unity assumption alone is not enough to promote intersensory integration.     

Influence of maternal reflective functioning on mothers’ and children's weight: A follow-up study

Based on cross-sectional research linking poor reflective functionining (RF) to eating disorders, the current follow-up study tested whether maternal RF would explain the variance of mothers’ and children's weight beyond the effects of maternal emotional dysregulation. During pregnancy (Time 1 [T1]), 51 women were administered the Difficulties in Emotion Regulation Scale (DERS) and interviewed using the Adult Attachment Interview (AAI). Seven months after delivery (Time 2 [T2]), mother–baby dyads who remained in the study (n = 44) were videotaped (Feeding Scale) during their feeding interaction. Last (Time 3 [T3]), the weight of the 34 children who were still in the study was collected at 3 years of age. Maternal AAI-RF at T1 did not correlate with the DERS at T1 nor with the quality of the feeding interacions at T2. However, it correlated, significantly, with maternal body mass index (BMI) at T1, r = −.298, P = .034, and marginally significantly with baby's BMI at T3, r = −.296, P = .089. Moreover, multiple regression models showed a trend indicating that maternal AAI-RF might explain the variance of mothers’ and children's weight beyond the effects of maternal emotional dysregulation. These findings suggest that working on maternal mentalization might contribute to helping prevent childhood obesity from pregnancy.     

Causal Reasoning and Clinical Practice: Challenges from Molecular Biology

Not only has the philosophical debate on causation been gaining ground in the last few decades, but it has also increasingly addressed the sciences. The biomedical sciences are among the most prominent fields that have been considered, with a number of works tackling the understanding of the notion of cause, the assessment of genuinely causal relations and the use of causal knowledge in applied contexts. Far from denying the merits of the debate on causation and the major theories it comprises, this paper is meant as a stimulus for theorists of causation in the philosophy of biomedicine, with a focus on clinical matters. Without aiming at putting forward an original theory of causation and starting from the narration of two actual but paradigmatic cases at the joints between biomedical research and clinical practice, we want to point out that some pathological situations addressed by molecular medicine actually prove resistant to (at least) some of our major epistemological accounts of causal explanation. Given this scenario, which is very frequent in our hospitals, our analysis aims to provide a stimulus for the debate among theorists of causation in biomedicine interested in real cases in science in practice. We believe that this might in turn encourage some more general rethinking of the complex intertwinement of science, philosophy of science and ethics, as well as of the role of philosophy of science for clinical medicine itself.

     

On Certainty: Wittgenstein and Einstein

The paper focuses on the role of relativistic ideas in Wittgenstein's philosophy. In particular, it focuses on On Certainty (1969), where in (305), Wittgenstein explicitly invokes Einstein's theory of relativity: “Here once more there is needed a step like the one taken in relativity theory.” The aim of the paper is to establish a connection between Wittgenstein and Einstein that is both theoretically and exegetically sound. In particular, the paper argues that Wittgenstein's reaction to scepticism closely resembles Einstein's reaction to the ether.     

Gender stereotypes and contact with gay men and lesbians: The mediational role of sexism and homonegativity

This study is grounded in Allport's intergroup contact theory and Herek's sexual prejudice theory. We aimed at (a) investigating the mediational role of sexism and homonegativity on the relation between gender, age, and contact with gay and lesbian people with gender stereotypes about gay men and lesbians; and (b) replicating and corroborating the direct associations found in previous research among these variables. The present research used secondary data from a survey conducted by the Italian National Institute of Statistics and comprehending a representative sample of 5,863 Italian adults. The results from path analysis indicated that both homonegativity and sexism partially mediated the effect of gender and age on gender stereotypes, whereas they totally mediated the effect of contact with gay and lesbian persons. Findings suggest that reducing sexist and homonegative attitudes and increasing contact with gay and lesbian people may reduce stereotypical beliefs about homosexual people.     

Italian Adagio: Every Law has Its Loophole

Science and Engineering Ethics - The Italian law of December 2010 establishes new criteria and parameters for the evaluation of faculty members. The parameters are represented by the number of...     

Residents’ Satisfaction with Cultural City Life: Evidence from EU Cities

This paper investigates the determinants of residents’ satisfaction with the cultural facilities supplied in their city. This topic is relevant from a policy perspective since the active participation of citizens to the cultural life of their town is crucial for the sustainable utilization of tangible cultural assets. By using the results of a large survey study conducted in 63 EU cities, the present paper shows that the exploitation of the urban cultural assets for the attraction of tourists and visitors is likely to produce a positive externality on residents’ satisfaction with the cultural life of their city, but just up to a certain threshold of tourist pressure. Above this threshold, a further increase in the number of tourists is associated with a reduction of residents’ contentment.

     

CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice

Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory. The molecular mechanisms underlying this function remain to be clarified. Several studies indicated extracellular signal-regulated kinases (ERKs), the phosphatidylinositol 3-kinase with its downstream effector AKT, and the phosphatase calcineurin as potential molecular substrates of extinction behavior. To test the involvement of these kinase and phosphatase activities in CB1-dependent extinction of conditioned fear behavior, conditioned CB1-deficient mice (CB1(-/-)) and wild-type littermates (CB1(+/+)) were sacrificed 30 min after recall of fear memory, and activation of ERKs, AKT, and calcineurin was examined by Western blot analysis in different brain regions. As compared with CB1(+/+), the nonreinforced tone presentation 24 h after auditory-cued fear conditioning led to lower levels of phosphorylated ERKs and/or calcineurin in the basolateral amygdala complex, ventromedial prefrontal cortex, dorsal hippocampus, and ventral hippocampus of CB1(-/-). In contrast, higher levels of phosphorylated p44 ERK and calcineurin were observed in the central nucleus of the amygdala of CB1(-/-). Phosphorylation of AKT was more pronounced in the basolateral amygdala complex and the dorsal hippocampus of CB1(-/-). We propose that the endogenous cannabinoid system modulates extinction of aversive memories, at least in part via regulation of the activity of kinases and phosphatases in a brain structure-dependent manner.     

The role of affordances in inhibition of return

Inhibition of return (IOR) is a response delay that occurs when the target is preceded by an irrelevant stimulus (cue) at the same location. IOR can be object based, as well as location based. The aim of the present study was to investigate the role of the pragmatic features of a visually presented object in causing IOR. Two experiments were carried out using different objects as stimuli, for which the graspable part (affordance) was clearly defined. The presentation of a whole object, with the part commonly used to grasp it located below, served as a cue. The presentation of either the graspable or the ungraspable part of the cued or uncued object served as the target Results showed that responses were slower when the graspable part was shown in the cued location than when the ungraspable part was shown in the same location. The effect was apparently linked to the kind of action necessary to grasp an object.