Causal Reasoning and Clinical Practice: Challenges from Molecular Biology

Not only has the philosophical debate on causation been gaining ground in the last few decades, but it has also increasingly addressed the sciences. The biomedical sciences are among the most prominent fields that have been considered, with a number of works tackling the understanding of the notion of cause, the assessment of genuinely causal relations and the use of causal knowledge in applied contexts. Far from denying the merits of the debate on causation and the major theories it comprises, this paper is meant as a stimulus for theorists of causation in the philosophy of biomedicine, with a focus on clinical matters. Without aiming at putting forward an original theory of causation and starting from the narration of two actual but paradigmatic cases at the joints between biomedical research and clinical practice, we want to point out that some pathological situations addressed by molecular medicine actually prove resistant to (at least) some of our major epistemological accounts of causal explanation. Given this scenario, which is very frequent in our hospitals, our analysis aims to provide a stimulus for the debate among theorists of causation in biomedicine interested in real cases in science in practice. We believe that this might in turn encourage some more general rethinking of the complex intertwinement of science, philosophy of science and ethics, as well as of the role of philosophy of science for clinical medicine itself.

     

Influence of maternal reflective functioning on mothers’ and children's weight: A follow-up study

Based on cross-sectional research linking poor reflective functionining (RF) to eating disorders, the current follow-up study tested whether maternal RF would explain the variance of mothers’ and children's weight beyond the effects of maternal emotional dysregulation. During pregnancy (Time 1 [T1]), 51 women were administered the Difficulties in Emotion Regulation Scale (DERS) and interviewed using the Adult Attachment Interview (AAI). Seven months after delivery (Time 2 [T2]), mother–baby dyads who remained in the study (n = 44) were videotaped (Feeding Scale) during their feeding interaction. Last (Time 3 [T3]), the weight of the 34 children who were still in the study was collected at 3 years of age. Maternal AAI-RF at T1 did not correlate with the DERS at T1 nor with the quality of the feeding interacions at T2. However, it correlated, significantly, with maternal body mass index (BMI) at T1, r = −.298, P = .034, and marginally significantly with baby's BMI at T3, r = −.296, P = .089. Moreover, multiple regression models showed a trend indicating that maternal AAI-RF might explain the variance of mothers’ and children's weight beyond the effects of maternal emotional dysregulation. These findings suggest that working on maternal mentalization might contribute to helping prevent childhood obesity from pregnancy.     

On Certainty: Wittgenstein and Einstein

The paper focuses on the role of relativistic ideas in Wittgenstein's philosophy. In particular, it focuses on On Certainty (1969), where in (305), Wittgenstein explicitly invokes Einstein's theory of relativity: “Here once more there is needed a step like the one taken in relativity theory.” The aim of the paper is to establish a connection between Wittgenstein and Einstein that is both theoretically and exegetically sound. In particular, the paper argues that Wittgenstein's reaction to scepticism closely resembles Einstein's reaction to the ether.     

Gender stereotypes and contact with gay men and lesbians: The mediational role of sexism and homonegativity

This study is grounded in Allport's intergroup contact theory and Herek's sexual prejudice theory. We aimed at (a) investigating the mediational role of sexism and homonegativity on the relation between gender, age, and contact with gay and lesbian people with gender stereotypes about gay men and lesbians; and (b) replicating and corroborating the direct associations found in previous research among these variables. The present research used secondary data from a survey conducted by the Italian National Institute of Statistics and comprehending a representative sample of 5,863 Italian adults. The results from path analysis indicated that both homonegativity and sexism partially mediated the effect of gender and age on gender stereotypes, whereas they totally mediated the effect of contact with gay and lesbian persons. Findings suggest that reducing sexist and homonegative attitudes and increasing contact with gay and lesbian people may reduce stereotypical beliefs about homosexual people.     

Italian Adagio: Every Law has Its Loophole

Science and Engineering Ethics - The Italian law of December 2010 establishes new criteria and parameters for the evaluation of faculty members. The parameters are represented by the number of...     

Residents’ Satisfaction with Cultural City Life: Evidence from EU Cities

This paper investigates the determinants of residents’ satisfaction with the cultural facilities supplied in their city. This topic is relevant from a policy perspective since the active participation of citizens to the cultural life of their town is crucial for the sustainable utilization of tangible cultural assets. By using the results of a large survey study conducted in 63 EU cities, the present paper shows that the exploitation of the urban cultural assets for the attraction of tourists and visitors is likely to produce a positive externality on residents’ satisfaction with the cultural life of their city, but just up to a certain threshold of tourist pressure. Above this threshold, a further increase in the number of tourists is associated with a reduction of residents’ contentment.

     

Practicing REBT in Italy: Cultural Aspects

This paper attempts to explore the cultural background for the adoption and practice of REBT by cognitive therapists in Italy since the 1980s. It is not an attempt to capture the history of Italian culture and philosophy from antiquity. Italian therapists tend to prefer the assessment phase of the ABC framework and not fully adopt REBT disputing interventions. They also attempt to link the ABC not only to the here and now but also to clients’ personal development. In our experience, they have combined REBT with constructivism and metacognition. These current features parallel the historical lack of confidence shown by many Italian philosophical thinkers—from Machiavelli to Gianni Vattimo—in the possibility of reducing reality to verification as well as the reproducible rules of logical rationality. The foregoing highlights the interest in exploring the emotional roots of politics, history, and concrete reality in the time frame following the 1980s. Some typical features of Italian social life, such as individualism, hierarchy, remote social distance, and competition can also be thought of as corresponding with the historical features of the way REBT has been adopted and functions in Italy.     

The appeal of the devil’s eye: social evaluation affects social attention

Humans typically exhibit a tendency to follow the gaze of conspecifics, a social attention behaviour known as gaze cueing. Here, we addressed whether episodically learned social knowledge about the behaviours performed by the individual bearing the gaze can influence this phenomenon. In a learning phase, different faces were systematically associated with either positive or negative behaviours. The same faces were then used as stimuli in a gaze-cueing task. The results showed that faces associated with antisocial norm-violating behaviours triggered stronger gaze-cueing effects as compared to faces associated with sociable behaviours. Importantly, this was especially evident for participants who perceived the presented norm-violating behaviours as far more negative as compared to positive behaviours. These findings suggest that reflexive attentional responses can be affected by our appraisal of the valence of the behaviours of individuals around us.     

An evaluation of the Italian version of the Fagerström Test for Nicotine Dependence

This study examined the psychometric properties of an Italian version of the Fagerstr?m Test for Nicotine Dependence in a sample of 593 smokers who were enrolled in a randomized Phase IV clinical trial to compare bupropion to placebo. This version was administered at baseline, and from each participant an expired air carbon monoxide (CO) measure was taken. Spearman correlations between the Total score and CO concentration were .27 in the combined sample and .27 and .25 among men and women. With respect to the internal consistency reliability, the coefficient alpha was low (alpha= .55) in the combined sample and among men (.59) and women (.50). While the Total score predicted abstinence at 7 wk., it was not significantly related to continuous abstinence at 12 mo. postrandomization. The properties of the Italian version of the Fagerstr?m Test for Nicotine Dependence appear to be consistent with other versions described in the literature.