Genetic testing for hereditary cancer: effects of alexithymia and coping strategies on variations in anxiety before and after result disclosure

This study assessed the impact of the results of genetic testing for hereditary cancer from a multifactorial health psychology perspective, considering that emotional expression plays a key role in psychological adjustment. Measures of dispositional and transactional coping strategies, anxiety and alexithymia were filled out by 77 participants in a longitudinal study design. Statistical analyses were performed using general linear models and partial least squares path modelling, low-constraint methods that are particularly useful in the behavioural sciences. While anxiety levels prior to the result announcement were predictive of the distress experienced by noncarriers, considerable variability was observed for mutation carriers. Some subjects who had lower anxiety levels before the test displayed greater anxiety afterwards, but others seemed to anticipate the distress they would experience with the result that they showed a decrease in anxiety. The mutation carriers behaved as though their adaptive functioning were reshaped by the test result, independent of their disposition and previous emotional state, except in the case of alexithymia. Difficulty expressing emotions prior to genetic testing contributed to a similar difficulty after receiving the result, adding to the latter's emotional impact by promoting emotion-focused coping strategies and increasing distress.     

Increasing compliance with medical examination requests directed to children with autism: effects of a high-probability request procedure

The purpose of this study was to evaluate the effectiveness of a high-probability (high-p) request sequence as a means of increasing compliance with medical examination tasks. Participants were children who had been diagnosed with autism and who exhibited noncompliance during general medical examinations. The inclusion of the high-p request sequence effectively increased compliance with medical examination tasks. In addition, the procedure was efficient, could be implemented by parents and medical professionals, and did not involve aversive procedures.     

Tapping in synchrony with a perturbed metronome: the phase correction response to small and large phase shifts as a function of tempo

When tapping is paced by an auditory sequence containing small phase shift (PS) perturbations, the phase correction response (PCR) of the tap following a PS increases with the baseline interonset interval (IOI), leading eventually to overcorrection (B. H. Repp, 2008). Experiment 1 shows that this holds even for fixed-size PSs that become imperceptible as the IOI increases (here, from 400 to 1200 ms). Earlier research has also shown (but only for IOI=500 ms) that the PCR is proportionally smaller for large than for small PSs (B. H. Repp, 2002a, 2002b). Experiment 2 introduced large PSs and found smaller PCRs than in Experiment 1, at all of the same IOIs. In Experiments 3A and 3B, the author investigated whether the change in slope of the sigmoid function relating PCR and PS magnitudes occurs at a fixed absolute or relative PS magnitude across different IOIs (600, 1000, 1400 ms). The results suggest no clear answer; the exact shape of the function may depend on the range of PSs used in an experiment. Experiment 4 examined the PCR in the IOI range from 1000 to 2000 ms and found overcorrection throughout, but with the PCR increasing much more gradually than in Experiment 1. These results provide important new information about the phase correction process and pose challenges for models of sensorimotor synchronization, which presently cannot explain nonlinear PCR functions and overcorrection.     

Linear mapping of numbers onto space requires attention

Mapping of number onto space is fundamental to mathematics and measurement. Previous research suggests that while typical adults with mathematical schooling map numbers veridically onto a linear scale, pre-school children and adults without formal mathematics training, as well as individuals with dyscalculia, show strong compressive, logarithmic-like non-linearities when mapping both symbolic and non-symbolic numbers onto the numberline. Here we show that the use of the linear scale is dependent on attentional resources. We asked typical adults to position clouds of dots on a numberline of various lengths. In agreement with previous research, they did so veridically under normal conditions, but when asked to perform a concurrent attentionally-demanding conjunction task, the mapping followed a compressive, non-linear function. We model the non-linearity both by the commonly assumed logarithmic transform, and also with a Bayesian model of central tendency. These results suggest that veridical representation numerosity requires attentional mechanisms.     

Eye gaze cannot be ignored (but neither can arrows)

Recent studies have tried to shed light on the automaticity of attentional shifts triggered by gaze and arrows with mixed results. In the present research, we aimed at testing a strong definition of resistance to suppression for orienting of attention elicited by these two cues. In five experiments, participants were informed with 100% certainty about the future location of a target they had to react to by presentation of either a direction word at the beginning of each trial or instructions at the beginning of each block. Gaze and arrows were presented before the target as uninformative distractors irrelevant for the task. The results showed similar patterns for gaze and arrows-namely, an interference effect when the distractors were incongruent with the upcoming target location. This suggests that the orienting of attention mediated by gaze and arrows can be considered as strongly automatic.     

The Interplay Of Autonomy And Relatedness In Hong Kong Chinese Single Mothers

The mediating effects of autonomy and relatedness on the relationship between self–esteem and life satisfaction were investigated among 49 single mothers. Among all tested variables in the dimension of relatedness, only network orientation (propensity to utilize one's available social support) was a mediator of the positive relationship between self–esteem and life satisfaction. No variable in the dimension of autonomy was a mediator. Three components of self–actualization contributed to the model: self–regard mediated the relationship between self–esteem and network orientation, spontaneity contributed to network orientation, self–acceptance contributed to life satisfaction directly and indirectly by contributing to self–regard. Findings suggest that Chinese single mothers' psychological adjustment can be enhanced by fostering their self–regard, self–acceptance, and readiness to seek help from trusted others.     

Cortical Acetylcholine, Reality Distortion, Schizophrenia, and Lewy Body Dementia: Too Much or Too Little Cortical Acetylcholine?

Aberrations in cortical cholinergic transmission have been hypothesized to mediate the development and manifestation of psychotic cognition. Based primarily on hypotheses about mesolimbic dopaminergic hyperactivity in schizophrenia, the actions of antipsychotic drugs, the trans-synaptic regulation of the excitability of basal forebrain corticopetal cholinergic neurons, and the role of cortical cholinergic inputs in attentional functions, we hypothesized that persistent disinhibition of cortical cholinergic inputs mediates the fundamental cognitive dysfunctions which form the basis for the development of positive symptoms in schizophrenia. In contrast to this hypothesis, Perry and Perry (1995), based on evidence from hallucinating patients with Lewy Body Dementia (LBD), concluded that the extensivelossof cortical acetylcholine allows irrelevant information to enter “conscious awareness” and thus hallucinations to emerge. The discussion of these contrasting hypotheses highlights the need for more dynamic and precise theories describing the cognitive variables and neuronal processes which contribute to the development and manifestation of psychotic cognition. While the hypothesis that a disinhibited cholinergic system mediates the evolution of psychotic symptoms corresponds more convincingly with current theories about the cognitive functions of cortical cholinergic inputs, both hypotheses stress the critical role of cortical acetylcholine in the highest levels of cognitive functioning.     

Spinoza’s Christology A Brief Summary

Abstract

This article summarizes a number of Spinoza texts relating to his Christology and soteriology based on his Christology. The texts show that Spinoza’s Christology underpins his formulation of human nature or the constitution of the essence of the human mind. Considering Spinoza’s texts concerning God or Nature, “Christ according to the spirit”, the spirit or mind of Christ, and human salvation or blessedness; this article illustrates that given the texts, the study of Spinoza’s Christian religion is skewed and ought to be more balanced. The author’s reading of Spinoza and its application to his work presented in this article provides a coherent and tenable understanding of Spinoza’s efforts “to commend and establish the authentic purpose of the Christian Religion”.