The role accorded to the public by philosophers of science 1

The role accorded to the public by scientists and philosophers of science has undergone an essential historical change in the last three centuries. Public participation in (witnessing of) scientific experiments was considered an important requirement for 17th century experimenters (e.g. for Boyle or Pascal). The cognitive role played by lay persons was later substantially downgraded; witnessing went out of fashion, while science became more and more esoteric and a matter for experts only. Part of this process was that all scientific disciplines became intensively compartmentalized and in consequence a rather puzzling or even paradoxical situation appeared: that the scientists themselves were and are being reduced epistemically to the status of lay persons, outside of their proper field of expertise (as was pointed out by J. Hardwig). The paper deals with some cognitive aspects of this historical process.     

Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Cut-free sequent and tableau systems for propositional Diodorean modal logics

We present sound, (weakly) complete and cut-free tableau systems for the propositional normal modal logicsS4.3, S4.3.1 andS4.14. When the modality is given a temporal interpretation, these logics respectively model time as a linear dense sequence of points; as a linear discrete sequence of points; and as a branching tree where each branch is a linear discrete sequence of points.Although cut-free, the last two systems do not possess the subformula property. But for any given finite set of formulaeX the superformulae involved are always bounded by a finite set of formulaeX* _L depending only onX and the logicL. Thus each system gives a nondeterministic decision procedure for the logic in question. The completeness proofs yield deterministic decision procedures for each logic because each proof is constructive.Each tableau system has a cut-free sequent analogue proving that Gentzen's cut-elimination theorem holds for these latter systems. The techniques are due to Hintikka and Rautenberg.Presented byDov M. Gabbay     

Modifications of the Poggendorff effect as a function of random dot textures between the verticals

In the present research, we investigated the modification of the strength of the Poggendortf illusion as a function of different densities ofrandom dot textures failing the space between the verticals. The results ofExperiment 1 show that the illusory effect is a nonlinear function ofthe texture parameterr, the ratio of black pixels to white and black pixels, with a minimum forr=0.5, approximately, and a maximum forr=0 andr=1. The results may be interpreted by an analytical model of perceptual space dynamics, in which the effect dependson the amount of interaction between points of different light intensity. A computer simulation performed by applying the analytical model to different values ofr shows a good agreement between the predictions and the experimental data. To test the hypothesis underlying the model, a second experiment was carried out to measure the magnitude of the expansion ofthe space between the verticals as a function of the parameterr. The results are consistent with the hypothesis of the model. The overall data are discussed in terms of their implications on various theories proposed for the Poggeadorff illusion.