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131.
Serradeil-Le Gal C Derick S Brossard G Manning M Simiand J Gaillard R Griebel G Guillon G 《Stress (Amsterdam, Netherlands)》2003,6(3):199-206
By activating three distinct vasopressin receptor isoforms called V1a-R, V1b-R (V3-R) and V2-R, vasopressin (VP) mediates a wide number of biological effects in mammals and may be involved in several pathological states. Up to now only specific V1a and V2 receptor agonists and antagonists have been successfully designed. The role of the V1b-R still remains partially unknown, due to the lack of selective V1b-R ligands and orally-active molecules, which are crucial tools for investigating the central and peripheral functions or pathological disorders associated with this receptor. In this review, we report the biological and pharmacological properties of the first two specific V1b-R ligands: d[Cha4] AVP, a high affinity V1b-R agonist and SSR149415, a potent orally-active V1b-R antagonist with good selectivity with respect to other VP/OT receptor isoforms and able to control ACTH secretion in vitro and in vivo. Indeed, these molecules constitute invaluable tools for exploring the central and peripheral roles of VP mediated via V1b receptors. Interestingly, SSR149415 displays potent anxiolytic and antidepressant-like activities, indicating that this new class of drugs has a promising therapeutical potential in the treatment of stress-related disorders, anxiety and depression. 相似文献
132.
In rapid streams of visual stimuli, identification of a first target interferes with identification of a second target presented within the next half second (the attentional blink or AB). It has been suggested that rapid perceptual decisions under masking interference involve interactions between frontal and posterior cortex. We investigated the neural correlates of the AB using functional magnetic resonance imaging (fMRI). Twelve subjects viewed rapid streams of black letters in which were embedded two white target letters (T1 and T2) separated by either 300 or 700 ms. As expected, fewer correct T2 identifications were observed in the short-delay condition. Corresponding fMRI statistical images showed increased activation in inferotemporal and posterior parietal cortex, but also in lateral frontal cortex and cerebellum in the short-delay condition suggesting that these brain regions are associated with perceptual decisions under masking interference. 相似文献
133.
Suicide-related behavior (SRB) is significantly more prevalent among female (40.8%) than among male (28%) inmates, although suicide risk is higher among the latter. When instrumental behavior (IB) is excluded and only suicidal acts (SA) considered, rates for the two groups are more comparable (11.9% and 16%, respectively). Compared with other female inmates, the SRB group is more suicidal, hostile, and impulsive and more likely to have been previously victimized and to be diagnosed with Axis I and II disorders. Women with IB are not significantly different from those with SA, except that their behavior provides significantly greater tension release. 相似文献
134.
Désiré L Veissier I Després G Delval E Toporenko G Boissy A 《Journal of comparative psychology (Washington, D.C. : 1983)》2006,120(3):280-287
Appraisal theories state that an emotion results from an individual's evaluation of a stimulating event, which is based on a set of criteria. Each criterion triggers specific expressions that can be modulated by the outcome of other criteria. The authors analyzed the effects of the criteria of suddenness, unfamiliarity, and their combination on behavioral and cardiac responses in lambs (Ovis aries). Lambs were exposed to a visual stimulus that appeared either rapidly or slowly and was either unfamiliar or familiar. Suddenness induced a startle response and an increase in heart rate. Unfamiliarity induced an orientation response. The combination of suddenness and unfamiliarity enhanced both the heart rate increase and the behavioral orientation response. These results support the hypotheses of specificity and modulation of emotional expressions. 相似文献
135.
Plan formation, retention, and execution in prospective memory: A new approach and age-related effects 总被引:3,自引:0,他引:3
Existing laboratory paradigms of prospective memory instruct subjects to remember to perform a single, isolated act at an appropriate point in the experiment. These paradigms do not completely capture many everyday complex prospective memory situations in which a series or set of delayed actions is planned to be executed in some subsequent period of time. We adapted a laboratory paradigm within which to study these prospective memory processes, and we investigated age-related influences on these prospective memory processes. Age-related declines were found in the planning, initiation, and execution of the set of tasks. In contrast, there were no age differences in plan retention or in the fidelity with which the plan was performed. 相似文献
136.
Peggy Bosch Gilles Van Luijtelaar Maurits Van Den Noort Julia Schenkwald Nicole Kueppenbender Sabina Lim Jos Egger Anton Coenen 《Scandinavian journal of psychology》2014,55(5):513-519
While previous studies on the MMPI‐2 in patients with schizophrenia and depression have used mixed samples of both early stage and chronic psychiatric patients. Here, it is investigated whether chronicity itself might have a differential effect on the MMPI‐2 profiles of these patients and whether demoralization ‘associated with long‐term illness’ affects the scales of the MMPI‐2. Thirty long‐term patients with schizophrenia, 30 long‐term patients with depression, and 30 healthy participants completed the MMPI‐2. Groups were compared on Clinical Scales and on the Restructured Clinical (RC) Scales. Patients with schizophrenia differed from patients with depression on 14 MMPI‐2 scales and from healthy controls on 10 scales, generally showing mean UT‐scores < 65, indicating a subjective experience of (near) normal functioning. Patients with depression differed from healthy controls on 17 scales mostly with UT‐scores > 65, indicating impaired functioning. Demoralization was higher in patients with depression than in patients with schizophrenia and both psychiatric groups differed from the healthy control group. It is concluded that long‐term patients with depression show impaired functioning and high demoralization, while long‐term patients with schizophrenia surprisingly show near normal functioning and less demoralization. 相似文献
137.
Karine Lévesque Teresa Kus Karine St-Jean Gilles Dupuis Bernard Thibault Peter G. Guerra France Bédard Bianca D’Antono 《Applied research in quality of life》2010,5(3):185-201
Quality of life (QoL) is reduced in patients with recurrent vasovagal (VVS) or unexplained syncope (US). Little is known concerning
the natural evolution of QoL following diagnosis. Psychological factors contributing to QoL improvement, such as psychological
distress and self-efficacy remain to be explored. The objective of this study is to examine whether QoL changes 2 months and
6 months following head-up tilt (HUT) testing as well as to determine whether psychological factors are predictive of changes
in QoL. Seventy-three patients undergoing HUT for recurrent syncope were interviewed 1 month before as well as 2 months and
6 months following HUT, using semi-structured interviews and questionnaires. Pre-HUT QoL was significantly worse than at the
2-month (p = 0.000) and 6-month follow-ups (p = 0.000). Psychological distress at baseline was associated with worse QoL 2 months post-HUT (Beta = .280; p = .024), independently of socio-demographic and clinical factors. Improved self-efficacy at follow-up predicted improvements
in QoL (Beta = −.186; p = .023). Two and 6 months post-HUT, QoL is mproved in patients with recurrent syncope. Better QoL is predicted by low psychological
distress and a heightened sense of self-efficacy following HUT. Strategies for enhancing self-efficacy and reducing psychological
distress could be an efficient way to promote QoL in patients suffering from recurrent syncope. 相似文献
138.
Dutilh Gilles Annis Jeffrey Brown Scott D. Cassey Peter Evans Nathan J. Grasman Raoul P. P. P. Hawkins Guy E. Heathcote Andrew Holmes William R. Krypotos Angelos-Miltiadis Kupitz Colin N. Leite Fábio P. Lerche Veronika Lin Yi-Shin Logan Gordon D. Palmeri Thomas J. Starns Jeffrey J. Trueblood Jennifer S. van Maanen Leendert van Ravenzwaaij Don Vandekerckhove Joachim Visser Ingmar Voss Andreas White Corey N. Wiecki Thomas V. Rieskamp Jörg Donkin Chris 《Psychonomic bulletin & review》2019,26(4):1051-1069
Psychonomic Bulletin & Review - Most data analyses rely on models. To complement statistical models, psychologists have developed cognitive models, which translate observed variables into... 相似文献
139.
Mark A. McDaniel Gilles O. Einstein Thomas Graham Erica Rall 《Applied cognitive psychology》2004,18(5):533-547
In real-world settings, execution of retrieved intentions must often be briefly delayed until an ongoing activity is completed (delayed-execute prospective memory tasks). Further, in demanding work settings, the ongoing activity itself can be interrupted. Experiment 1 examined the effects of the delay length (5, 15, 40 s), the presence of an interruption within that delay, and the length of the interruption on prospective memory performance. Delay length did not significantly affect performance, but interruptions produced significant decrements in performance relative to a delay alone. The length of the interruptions (10 vs. 20 s) did not significantly affect performance. Experiment 2 replicated the negative effects of interruptions, and found that these effects could be overcome with a simple external mnemonic. We suggest that in demanding work environments where interruptions are likely, external cues are advisable, especially where prospective memory failures have critical consequences. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
140.
Light as a modulator of cognitive brain function 总被引:1,自引:0,他引:1