Functional and pharmacological characterization of the first specific agonist and antagonist for the V1b receptor in mammals

By activating three distinct vasopressin receptor isoforms called V1a-R, V1b-R (V3-R) and V2-R, vasopressin (VP) mediates a wide number of biological effects in mammals and may be involved in several pathological states. Up to now only specific V1a and V2 receptor agonists and antagonists have been successfully designed. The role of the V1b-R still remains partially unknown, due to the lack of selective V1b-R ligands and orally-active molecules, which are crucial tools for investigating the central and peripheral functions or pathological disorders associated with this receptor. In this review, we report the biological and pharmacological properties of the first two specific V1b-R ligands: d[Cha4] AVP, a high affinity V1b-R agonist and SSR149415, a potent orally-active V1b-R antagonist with good selectivity with respect to other VP/OT receptor isoforms and able to control ACTH secretion in vitro and in vivo. Indeed, these molecules constitute invaluable tools for exploring the central and peripheral roles of VP mediated via V1b receptors. Interestingly, SSR149415 displays potent anxiolytic and antidepressant-like activities, indicating that this new class of drugs has a promising therapeutical potential in the treatment of stress-related disorders, anxiety and depression.     

Neural correlates of dual task interference in rapid visual streams: an fMRI study

In rapid streams of visual stimuli, identification of a first target interferes with identification of a second target presented within the next half second (the attentional blink or AB). It has been suggested that rapid perceptual decisions under masking interference involve interactions between frontal and posterior cortex. We investigated the neural correlates of the AB using functional magnetic resonance imaging (fMRI). Twelve subjects viewed rapid streams of black letters in which were embedded two white target letters (T1 and T2) separated by either 300 or 700 ms. As expected, fewer correct T2 identifications were observed in the short-delay condition. Corresponding fMRI statistical images showed increased activation in inferotemporal and posterior parietal cortex, but also in lateral frontal cortex and cerebellum in the short-delay condition suggesting that these brain regions are associated with perceptual decisions under masking interference.     

Nonfatal suicide-related behavior among inmates: testing for gender and type differences

Suicide-related behavior (SRB) is significantly more prevalent among female (40.8%) than among male (28%) inmates, although suicide risk is higher among the latter. When instrumental behavior (IB) is excluded and only suicidal acts (SA) considered, rates for the two groups are more comparable (11.9% and 16%, respectively). Compared with other female inmates, the SRB group is more suicidal, hostile, and impulsive and more likely to have been previously victimized and to be diagnosed with Axis I and II disorders. Women with IB are not significantly different from those with SA, except that their behavior provides significantly greater tension release.     

Appraisal process in sheep (Ovis aries): interactive effect of suddenness and unfamiliarity on cardiac and behavioral responses

Appraisal theories state that an emotion results from an individual's evaluation of a stimulating event, which is based on a set of criteria. Each criterion triggers specific expressions that can be modulated by the outcome of other criteria. The authors analyzed the effects of the criteria of suddenness, unfamiliarity, and their combination on behavioral and cardiac responses in lambs (Ovis aries). Lambs were exposed to a visual stimulus that appeared either rapidly or slowly and was either unfamiliar or familiar. Suddenness induced a startle response and an increase in heart rate. Unfamiliarity induced an orientation response. The combination of suddenness and unfamiliarity enhanced both the heart rate increase and the behavioral orientation response. These results support the hypotheses of specificity and modulation of emotional expressions.     

Modeling the Balanced Inventory of Desirable Responding: Evidence in Favor of a Revised Model of Socially Desirable Responding

Paulhus (1984) proposed a 2-factor model of socially desirable responding (SDR) and created the Balanced Inventory of Desirable Responding (BIDR) to capture the 2 dimensions: self-deceptive enhancement and impression management. However, the 2-factor model has yet to be supported via confirmatory factor analysis (CFA) of the BIDR. Paulhus and Reid (1991) proposed a revised model of SDR, which bifurcated the self-deceptive enhancement dimension into 2 factors: self-deceptive enhancement (SDE; positively keyed items) and self-deceptive denial (SDD; negatively keyed items). Thus, it was considered useful to test the revised SDR model on the BIDR, as this might have implications for the manner in which the BIDR should be scored. Additionally, as the BIDR subscales might be positively correlated, it was considered useful from a both a theoretical and practical perspective to test the possibility that the BIDR might measure a general SDR process. Based on a sample of 466 adults, Paulhus and Reid's revised model of SDR was largely supported when tested via CFA on a bifactor model, which included a first-order general SDR factor and 2 nested factors. Thus, applied researchers might consider using total BIDR composite scores, a self-deceptive enhancement composite score (positively keyed items), and impression management composite scores. However, ideally, researchers would use a bifactor model to test substantive hypotheses, as the bifactor model partitions true score variance into unique sources, which facilitates less ambiguous interpretations of effects.     

A Perception-Action Coupling Type of Control in Long Jumping

The authors' goal was to identify the control mechanisms used by long jumpers (N = 6) to precisely position their foot at the board. In addition to the intertrial method usually used in previous research, an original method based on a trial-by-trial analysis was also implemented. If the approach to the board in long jumping encompasses two distinct sequences separated by a key step that marks the initiation of visual control, then a trial-by-trial analysis should reveal those sequences, regardless of the amount of adjustment: The step number at which regulation is initiated should be the same irrespective of the amount of adjustment. If, in contrast, a perception-action coupling mechanism operates, then the step number at which regulation is initiated should be a function of the amount of adjustment: A linear relation between those 2 variables should emerge. The results of the present study are compatible with continuous control mechanisms based on a perception-action coupling.     

Importance effects on performance in event‐based prospective memory tasks

In the present study we manipulated the importance of performing two event‐based prospective memory tasks. In Experiment 1, the event‐based task was assumed to rely on relatively automatic processes, whereas in Experiment 2 the event‐based task was assumed to rely on a more demanding monitoring process. In contrast to the first experiment, the second experiment showed that importance had a positive effect on prospective memory performance. In addition, the occurrence of an importance effect on prospective memory performance seemed to be mainly due to the features of the prospective memory task itself, and not to the characteristics of the ongoing tasks that only influenced the size of the importance effect. The results suggest that importance instructions may improve prospective memory if the prospective task requires the strategic allocation of attentional monitoring resources.     

The importance of cue familiarity and cue distinctiveness in prospective memory

Abstract

Both retrospective cued-memory tasks and event-based prospective memory tasks require that cue and target information be associated, and that aspects of that association be reinstated for successful remembering. These functional similarities between retrospective memory and prospective memory were the bases for the hypothesis that the familiarity and the distinctiveness of the target event (cue) would influence prospective memory performance. Experiment 1, focusing on target familiarity, found a nominal advantage in prospective memory with unfamiliar target events. Experiment 2 showed a significant benefit for unfamiliar target events, as well as for target events that were distinctive relative to the local context. Additionally, prospective memory performance did not reliably correlate with explicit retrospective memory tasks (recall and recognition), but did correlate with an indirect retrospective memory task (word fragment completion). This pattern suggests and helps specify the general view that prospective memory processes may be similar to those involved in both direct and indirect tests of retrospective memory.     

Breast cancer: The intention to have a mammography and a clinical breast examination - application of the theory of planned behavior

Abstract

The purpose of these cross sectional studies was to identify the psychosocial factors explaining women's intention to have a mammography within the next two years and their intention to have a clinical breast examination (CBE) by a professional within the next year. Two random samples of women aged 40–69 years (n_a = 354, n_b = 344) completed a self-administered questionnaire that investigated theoretical constructs of the theory of planned behavior. The results of structural equation modeling showed that subjective norms and perceived behavioral control explained 81 % of the variance in intention of having a mammography. Sixty-five percent (65%) of the variance in intention of having a CBE was explained by attitude and perceived behavioral control. In conclusion, women need to be better informed, have better skills to overcome psychological and physical barriers in performing preventive breast behaviors, and promotion of preventive breast cancer methods should consider people significant for women.     

Assessing the Structural and Psychometric Properties of a New Personality Measure for Use With Military Personnel in the French Armed Forces

We evaluated the measurement properties of a new personality scale for use with military personnel in the French Navy (N = 1,266). Principal components analyses indicated a five-factor structure assessing emotional stability, ascendancy, openness, agreeableness, and conscientiousness. Each factor comprised two facets that included 7 items per facet for a total of 70 items. Reliability analyses indicate that the factors and corresponding facets were internally consistent and temporally stable. Validity analyses indicate that the TAMI-P was significantly correlated with comparable measures of personality—correlations ranged from .53 to .68 with the Revised NEO Personality Inventory and the Big Five Questionnaire.