Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis

TRAP-1 is a mitochondrial heat shock protein (HSP), recently identified in Saos-2 osteosarcoma cells adapted to mild oxidative stress induced by diethylmaleate (DEM). TRAP-1 mRNA expression is increased in DEM-adapted cells as well as in tumor cells resistant to 5-fluorouracil and to platin derivatives. Since a strong decrease of TRAP-1 protein levels, upon cisplatin treatment, is observed only in controls but not in the DEM-adapted counterpart, a possible role for this protein in the development of resistant phenotypes could be hypothesized. To characterize the protective role of TRAP-1 against oxidative stress and apoptosis, stable transfectants were generated and characterized for their response to different stress types. These stable clones expressing constitutively high TRAP-1 levels: (i) are more resistant to H2O2-induced DNA damage and to apoptosis by cisplatin; (ii) contain higher reduced glutathione (GSH) levels than control cells; and (iii) do not release the apoptosis-inducing factor into the nucleus upon cisplatin treatment. Furthermore, high TRAP-1 levels interfere with caspase 3 activation. These results confirm the anti-apoptotic role of TRAP-1, and suggest that increased expression of this mitochondrial HSP in DEM-adapted and chemoresistant cells could be part of a pro-survival signaling pathway aimed to evade toxic effects of oxidants and anticancer drugs.     

Social conditioning and its proper control procedures.

In Expt I, eight infants received response-contingent social stimulation, while another eight infants received response-independent social stimulation. Both groups' vocalization rates similarly increased from baseline to stimulation periods and decreased from stimulation to extinction periods. In Expt II, 12 infants were given continuous social stimulation (elicitation treatment) for one period, and, in a second period, stimulation was withheld for 5 sec contingent upon each vocalization (omission treatment). Response rates were similar for both periods, and rates decreased when social stimulation was removed (mobile treatment). In both studies social stimulation increased vocalization rates and rate of responding was insensitive to the programmed contingency. There were, however, fewer “bursts” of responses with the negative and positive contingencies as compared with response-independent stimulation.     

Short-term effects of a multi-disciplinary cardiac rehabilitation programme on psychological well-being, exercise capacity and weight in a sample of obese in-patients with coronary heart disease: a practice-level study

Given that many patients referred to cardiac rehabilitation (CR) are obese, diet therapy, exercise training, nutritional and psychological counselling for both obesity and psychological distress should be included as important components in all CR programmes. In this practice-level, observational study we evaluated the short-term within-group effects of a four-week multi-factorial inpatient CR programme specifically addressed to weight loss, fitness improvement and psychological health increase on 176 obese in-patients with coronary heart disease (CHD). Outcome measures were exercise capacity measured with estimated metabolic equivalents (METs), body mass index (BMI) and psychological well-being (PGWBI). Results show statistically significant improvements in all the PGWBI sub-scales and total score, except in general health (p = 0.393). No moderation effects were found for BMI class, age, diabetes and ejection fraction (EF). METs significantly increased by 30.3% (p < 0.001) and BMI decreased by 1.37 points (p < 0.001). Significant correlations were found between BMI and weight reductions with PGWBI anxiety and total score improvements. This multi-disciplinary CR programme including diet therapy, exercise training and psychological counselling provides indication for short-term within-group effectiveness on functional exercise capacity, BMI and PGWBI in a sample of obese in-patients with CHD. However, controlled studies are needed to corroborate the results we found.     

Time-based prospective remembering: Interference and facilitation in a dual task

The aim of this study was to analyse prospective memory behaviour when people have to fulfil two different intentions whose retention intervals partially overlapped. More specifically, the purpose of the study was to explore the effects of a secondary PM task (either time-based or event-based) on performance of a main time-based PM task. Four embedded conditions were tested: two event-based ones and two time-based ones. The time- and event-based interpolated tasks differed in how closely their target time was to the 20-minute response required by the main time-based task (16th and 19th min., respectively). The results indicated that when a main time-based prospective memory task shares a portion of the retention interval with a second time-based prospective task, this overlapping facilitated performance on the main task. However, the interpolated tasks appeared to be affected by the moment in which they were administered during the execution of the main time-based task. More specifically, a decrease in the interpolated task performance was observed when this was time-based and had to be executed very closely to the target time of the main task. On the contrary, when the two tasks were different (event-based vs. time-based), there was neither interference, nor facilitation.     

The Relevance of Multiculturalism for Aging

Though multiculturalists focus on race and minority status, issues of central importance to the aged, multiculturalism has not infiltrated the gerontology literature. However, since the so-called natural stages of life are cultural formations, each one a valuable creation, the topic of aging would certainly benefit from a connection to multiculturalism and its critique of the demands of assimilation.     

The Relative Contribution of Diagnostic and Psychosocial Variables to Severity of Suicidal Ideation

The present study examined the relative contribution of diagnostic and psychosocial factors to the prediction of severity of suicidal ideation in a sample of 78 college students. Using hierarchical regression analyses to control for each set of factors, psychosocial variables were found to consistently predict level of suicidal ideation. In contrast, diagnostic variables including diagnosis of substance abuse and composite scores for depression and anxiety were unrelated to level of suicidality. An examination of individual diagnoses revealed no predictable relationships with severity of suicidality in this population. The results were discussed from several methodological viewpoints.     

The Emergence of Creativity

Creativity is one of the central dimensions of human achievement and social development and has always fascinated scientists and non-scientists alike. But what is the essential nature of creativity? And what is the role of consciousness in the emergence of creativity? If it is true that it has been explored in many aspects in the cognitive and neurobiological field, it is also true that the lore chest—from which the conscious mind through unconscious mechanisms extracts the rough material that is then brought to the surface—has been less investigated. The purpose of this article is to give an account of how the multiplicity of levels of awareness is made possible by a spontaneous order that has nothing to do with a monolithic view of creativity.     

Immigration,language proficiency,and autobiographical memories: Lifespan distribution and second-language access

This investigation examined two controversies in the autobiographical literature: how cross-language immigration affects the distribution of autobiographical memories across the lifespan and under what circumstances language-dependent recall is observed. Both Spanish/English bilingual immigrants and English monolingual non-immigrants participated in a cue word study, with the bilingual sample taking part in a within-subject language manipulation. The expected bump in the number of memories from early life was observed for non-immigrants but not immigrants, who reported more memories for events surrounding immigration. Aspects of the methodology addressed possible reasons for past discrepant findings. Language-dependent recall was influenced by second-language proficiency. Results were interpreted as evidence that bilinguals with high second-language proficiency, in contrast to those with lower second-language proficiency, access a single conceptual store through either language. The final multi-level model predicting language-dependent recall, including second-language proficiency, age of immigration, internal language, and cue word language, explained ¾ of the between-person variance and ¹/₅ of the within-person variance. We arrive at two conclusions. First, major life transitions influence the distribution of memories. Second, concept representation across multiple languages follows a developmental model. In addition, the results underscore the importance of considering language experience in research involving memory reports.