Adrenal gland responses to lipopolysaccharide after stress and ethanol administration in male rats

All forms of stress, including restraint stress (RS) and lipopolysaccharide (LPS) administration, activate the hypothalamic-pituitary-adrenal (HPA) axis. LPS binds to a recognition protein (CD14) and toll-like receptor 2/4 in different cells and tissues, including the adrenal gland, to induce the production of cytokines and cause upregulation of cyclooxygenase and nitric oxide synthase (NOS) enzymes. Acute ethanol exposure activates the HPA axis, but in some conditions prolonged administration can dampen this activation as well as decrease the inflammatory responses to LPS. Therefore, this study was designed to evaluate the adrenal response to a challenge dose of LPS (50 μg/kg) injected i.p., after submitting male rats to RS, twice a day (2 h each time) for 5 days and/or ethanol administration (3 g/kg) by gavage also for 5 days, twice daily. At the end of the experiment, plasma corticosterone concentrations and adrenal gland content of prostaglandin E (PGE) and NOS activity were measured as stress mediators. The results showed that repetitive ethanol administration attenuated the adrenal stress response to LPS challenge alone and after RS, by preventing the increase in plasma corticosterone concentrations and by decreasing the PGE content and NOS activity in the adrenal gland. Therefore, we conclude that moderate alcohol consumption could attenuate the effects of psychophysical stress and impair an inflammatory response.     

The effect of novel distractors on performance in focused attention tasks: A cognitive-psychophysiological approach

In the present study, we examined whether or not novel stimuli affect performance in a focused attention task. Participants responded to a central target while an irrelevant distractor in the visual display was occasionally changed. In Experiment 1, both target and distractor were presented centrally within the focus of attention. In Experiment 2, a central target was presented along with an irrelevant distractor at a peripheral location, outside the focus of attention. Novel distractors were associated with longer latencies and enhanced orienting responses (as measured by skin conductance responses) only when presented at an attended location. In contrast, as is demonstrated in Experiment 3, the same peripheral novel distractors interfered with task performance when they possessed task-relevant information. These results indicate that there is a fundamental difference between novel stimuli and task-relevant stimuli. Whereas the former exert influence only within the focus of attention, the latter affect performance even when positioned in an unattended location. Our findings have important implications for the operation of visual attention.     

Construct validity of the relationship profile test: impact of gender, gender role, and gender role stereotype

Research supports the construct validity of the Relationship Profile Test (RPT; Bornstein & Languirand, 2003), a 30-item, self-report measure of destructive overdependence (DO), dysfunctional detachment (DD), and healthy dependency. In this investigation, we assessed the relationships of gender, gender role, and gender role stereotype ratings to RPT subscale scores. In Study 1, we replicated earlier patterns of gender differences in RPT scores, assessed cross-sample consistency in gender difference effect sizes, and provided preliminary nonclinical norms for the RPT subscales. Study 2 showed that--as expected--DO items are perceived as stereotypically feminine, whereas DD items are perceived as stereotypically masculine. In Study 3, we examined the relationships of RPT subscale scores to masculinity, femininity, and androgyny scores. We discuss the theoretical, empirical, and clinical implications of these findings.     

Physical activity and psychological well-being in advanced age: a meta-analysis of intervention studies

A meta-analysis examined data from 36 studies linking physical activity to well-being in older adults without clinical disorders. The weighted mean-change effect size for treatment groups (d(C). = 0.24) was almost 3 times the mean for control groups (d(C). = 0.09). Aerobic training was most beneficial (d(C). = 0.29), and moderate intensity activity was the most beneficial activity level (d(C). = 0.34). Longer exercise duration was less beneficial for several types of well-being, though findings are inconclusive. Physical activity had the strongest effects on self-efficacy (d(C).= 0.38), and improvements in cardiovascular status, strength, and functional capacity were linked to well-being improvement overall. Social-cognitive theory is used to explain the effect of physical activity on well-being.     

Behaviorally referenced experimentation and symptom validation: a paradigm for 21st-century personality disorder research

Construct validity problems in contemporary personality disorder (PD) symptoms and diagnoses include poor interrater reliability, high comorbidity, limited discriminant validity, and inadequate criterion validity. These problems are due in part to a limited range of outcome measures and research methods utilized by PD investigators: The vast majority of PD studies use correlational methods to assess relationships among questionnaire- and interview-based self-reports. To strengthen the PD database, researchers must: (1) emphasize behaviorally referenced criterion validation of PD symptoms; and (2) explore PD dynamics using manipulations that alter PD-related psychological processes and produce measurable changes in behavior. Frameworks for conducting behaviorally referenced PD symptom validation studies and experiments are outlined. The advantages of a behaviorally referenced experimental approach to PD research are described, along with possible objections to this approach.     

Web-based research: Methodological variables’ effects on dropout and sample characteristics

Previous research has made a beginning in addressing the importance of methodological differences in Web-based research. The present paper presents four studies investigating whether sample type, financial incentives, time when personal information is requested, table design, and method of obtaining informed consent influence dropout and sample characteristics(both demographics and measured attitudes). Undergraduates were less likely to drop out than nonstudents, and nonstudents offered a financial incentive were less likely to drop out than those offered no incentive. Complex tables, tables that were too wide, requests for personal information on the first page, and the imposing of additional informed consent procedures each provoked early dropout. As was expected, nonstudents and those presented with complex tables showed more measurement error and attitude differences. Asking for personal information and imposing additional consent procedures affected the demographic makeup, raising challenges to external validity.     

Histrionic Personality Disorder, Physical Attractiveness, and Social Adjustment

Histrionic personality disorder (HPD) is the only DSM-IV personality disorder (PD) explicitly linked to a person's physical appearance. This study examined the HPD–attractiveness link in a mixed-sex sample of college students. Consistent with expectations, HPD women were rated higher in attractiveness than women with other PDs or no PD. However, a parallel HPD–attractiveness link was not found in men. Subsequent analyses indicated that, relative to less attractive HPD women, more attractive HPD women (a) had a more varied and supportive social network, (b) exhibited more negative behaviors in important relationships, and (c) showed greater use of immature defenses, and less reliance on image-distorting, self-sacrificing, and mature defenses. Similar attractiveness–defense relationships were found in HPD men, but parallel results did not emerge for men in the other two domains. Implications of these findings are discussed, and suggestions for future studies are offered.     

The effects of prior expectations and outcome knowledge on polygraph examiners' decisions

The present study deals with the question of whether judgments made by experts working in familiar contexts are affected by prior expectations and beliefs. Two experiments in which prior expectations were manipulated were designed to determine whether and to what extent polygraph examiners are affected by their prior expectations when analyzing and interpreting polygraph charts. Prior expectations affected the examiners' judgments when the polygraph charts did not include clear indications of guilt or innocence, but when the objective physiological evidence included strong indications which clearly contradicted the examiner's expectations, judgments were not affected by these expectations. Theoretical and practical implications of these results are discussed.