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71.
Autistic Disorder (AD) is a phenotypically heterogeneous condition characterized by impairments in social interaction, communication,
and the presence of repetitive behavior and restricted interests. It is a model syndrome to investigate neural interaction
and integration at the nexus of language and social cognition. This paper considers the problems of language acquisition in
AD from an evolutionary and ontogenetic context. Following a review of normal language development during the formative years
of brain development, we examine what is known about infant linguistic and nonlinguistic precursors of language acquisition
in AD and examine how anomalies of several processes relate to language abnormalities manifest by the early elementary school
years. Population heterogeneity and practical limitations inherent to the study of children currently limit a comprehensive
understanding of the significance of specific neurological abnormalities in relation to observed deficits. However, convergent
evidence implicates anomalies of a widely distributed neural network, involving superior temporal sulcus, superior temporal
gyrus, supramarginal gyrus, insula, inferior frontal gyrus, hippocampus, amygdala and cerebellum. These anomalies reflect
the cumulative effects of genetic, epigenetic and environmental influences. Neuropsychological studies of language in AD provide
an important means to define the phenotypic variation resulting from alterations in neural architecture. By mapping broad
relationships between key symptoms, neuropsychological impairment and neural substrate, information derived from these studies
enable a level of analysis that bridges the gap between the genome and the syndrome. Further study of children during the
critical first 2 years of life using behavioral, electrophysiological, and functional neuroimaging methods is essential. 相似文献
72.
This study reviews empirical evidence for Moghaddam's model "Staircase to Terrorism," which portrays terrorism as a process of six consecutive steps culminating in terrorism. An extensive literature search, where 2,564 publications on terrorism were screened, resulted in 38 articles which were subject to further analysis. The results showed that while most of the theories and processes linked to Moghaddam's model are supported by empirical evidence, the proposed transitions between the different steps are not. These results may question the validity of a linear stepwise model and may suggest that a combination of mechanisms/factors could combine in different ways to produce terrorism. 相似文献
73.
74.
Acquired epileptiform aphasia (AEA) is characterized by deterioration in language in childhood associated with seizures or epileptiform electroencephalographic abnormalities. Despite an extensive literature, discrepancies and contradictions surround its definition and nosological boundaries. This paper reviews current conceptions of AEA and highlights variations in the aphasic disturbance, age of onset, epileptiform EEG abnormalities, temporal course, and long-term outcome. We suggest that AEA, rather than being a discrete entity, is comprised of multiple variants that have in common the features of language regression and epileptiform changes on EEG. Viewed this way, we argue that AEA can be conceptualized on a spectrum with other epileptiform neurocognitive disorders that may share pathophysiological features. The implications of this viewpoint are discussed, with emphasis on parallels between the AEA variants and regressive autistic spectrum disorders. 相似文献
75.
Shonagh R. H. Scott Gerry Kent Alison Rowlands 《Journal of clinical psychology in medical settings》2001,8(4):301-305
Limb reconstruction is an orthopaedic surgical technique designed to restore or improve functioning and appearance. The aims of the present study were to investigate levels of psychological distress in adults undergoing limb reconstruction as a result of traumatic injury, to examine which variables could account for any variations in distress during and after treatment, and to ascertain the potential relevance of psychological interventions. A cross-sectional sample of patients completed measures of psychological distress, posttraumatic symptomatology, coping, social support, pain, and disability. Self-reported levels of psychological distress and posttraumatic symptoms were high but did not tend to vary across stage of treatment, suggesting that distress is not solely attributable to limb reconstruction treatment per se but to other factors. Both medical variables (pain and mobility) and psychological variables (symptoms of trauma and coping strategies) accounted for a significant percentage of the variance in HAD scores. These results suggest that both medical and psychological interventions have potential for reducing distress and increasing well-being in an orthopaedic population who are experiencing high levels of emotional distress. 相似文献
76.
Yeates KO Bigler ED Dennis M Gerhardt CA Rubin KH Stancin T Taylor HG Vannatta K 《Psychological bulletin》2007,133(3):535-556
The authors propose a heuristic model of the social outcomes of childhood brain disorder that draws on models and methods from both the emerging field of social cognitive neuroscience and the study of social competence in developmental psychology/psychopathology. The heuristic model characterizes the relationships between social adjustment, peer interactions and relationships, social problem solving and communication, social-affective and cognitive-executive processes, and their neural substrates. The model is illustrated by research on a specific form of childhood brain disorder, traumatic brain injury. The heuristic model may promote research regarding the neural and cognitive-affective substrates of children's social development. It also may engender more precise methods of measuring impairments and disabilities in children with brain disorder and suggest ways to promote their social adaptation. 相似文献
77.
Incrementality and Prediction in Human Sentence Processing 总被引:1,自引:0,他引:1
We identify a number of principles with respect to prediction that, we argue, underpin adult language comprehension: (a) comprehension consists in realizing a mapping between the unfolding sentence and the event representation corresponding to the real-world event being described; (b) the realization of this mapping manifests as the ability to predict both how the language will unfold, and how the real-world event would unfold if it were being experienced directly; (c) concurrent linguistic and nonlinguistic inputs, and the prior internal states of the system, each drive the predictive process; (d) the representation of prior internal states across a representational substrate common to the linguistic and nonlinguistic domains enables the predictive process to operate over variable time frames and variable levels of representational abstraction. We review empirical data exemplifying the operation of these principles and discuss the relationship between prediction, event structure, thematic role assignment, and incrementality. 相似文献
78.
The biological bases of unfairness: Neuroimaging evidence for the distinctiveness of procedural and distributive justice 总被引:1,自引:0,他引:1
James H. Dulebohn Donald E. Conlon Issidoros Sarinopoulos Robert B. Davison Gerry McNamara 《Organizational behavior and human decision processes》2009,110(2):140
A classic debate in the organizational justice literature concerns the question of whether procedural justice and distributive justice are independent constructs. We investigate this question by using fMRI methods to examine brain activation patterns associated with procedural and distributive unfairness. We observed a clear dissociation of activation between these two forms of justice, and only a minimal amount of shared activation in the hypothesized regions. Specifically, unfair procedures evoked greater activation in parts of the brain related to social cognition, such as the ventrolateral prefrontal cortex (VLPFC) and the superior temporal sulcus (STS), whereas unfair outcomes evoked greater activation in more emotional areas of the brain, such as the anterior cingulate cortex (ACC), anterior insula (AI) and the dorsolateral prefrontal cortex (DLPFC). We interpret the findings as supporting the notion that the two forms of justice reflect distinct constructs, while recognizing that, as forms of justice, they are closely related nomologically. 相似文献
79.
This study examined the longer term effect of traumatic brain injury (TBI), approximately 18 months post-injury, on emerging narrative discourse skills of 85 children with orthopaedic injury (OI), 43 children with moderate TBI, and 19 children with severe TBI who were between 3 years and 6 years 11 months at injury. Children with TBI performed worse than children with OI on most discourse indices. Children with severe TBI were less proficient than children with moderate TBI at identifying unimportant story information. Age and pragmatic skills were predictors of discourse performance. 相似文献
80.
We investigated the retrieval of location information, and the deployment of attention to these locations, following (described) event-related location changes. In two visual world experiments, listeners viewed arrays with containers like a bowl, jar, pan, and jug, while hearing sentences like “The boy will pour the sweetcorn from the bowl into the jar, and he will pour the gravy from the pan into the jug. And then, he will taste the sweetcorn”. At the discourse-final “sweetcorn”, listeners fixated context-relevant “Target” containers most (jar). Crucially, we also observed two forms of competition: listeners fixated containers that were not directly referred to but associated with “sweetcorn” (bowl), and containers that played the same role as Targets (goals of moving events; jug), more than distractors (pan). These results suggest that event-related location changes are encoded across representations that compete for comprehenders’ attention, such that listeners retrieve, and fixate, locations that are not referred to in the unfolding language, but related to them via object or role information. 相似文献