Ethical Dilemmas in Genetic Testing: Examples from the Cuban Program for Predictive Diagnosis of Hereditary Ataxias

Predictive testing protocols are intended to help patients affected with hereditary conditions understand their condition and make informed reproductive choices. However, predictive protocols may expose clinicians and patients to ethical dilemmas that interfere with genetic counseling and the decision making process. This paper describes ethical dilemmas in a series of five cases involving predictive testing for hereditary ataxias in Cuba. The examples herein present evidence of the deeply controversial situations faced by both individuals at risk and professionals in charge of these predictive studies, suggesting a need for expanded guidelines to address such complexities.     

Probability judgments of agency: Rational or irrational?

We studied how people attribute action outcomes to their own actions under conditions of uncertainty. Participants chose between left and right keypresses to produce an action effect (a corresponding left or right light), while a computer player made a simultaneous keypress decision. In each trial, a random generator determined which of the players controlled the action effect at varying probabilities, and participants then judged which player had produced it. Participants’ effect control ranged from 20% to 80%, varied blockwise, and they could use trial-by-trial feedback to optimize the accuracy of their agency judgments. Participants tended to attribute action effects to themselves (agency bias), probably reflecting a rational guessing strategy of always naming the more likely player. However, participants systematically neglected information favoring the computer player as the agent, even under conditions where this bias could only harm judgment accuracy. We conclude that agency biases have both rational and irrational components.     

The Innateness Hypothesis and Mathematical Concepts

In historical claims for nativism, mathematics is a paradigmatic example of innate knowledge. Claims by contemporary developmental psychologists of elementary mathematical skills in human infants are a legacy of this. However, the connection between these skills and more formal mathematical concepts and methods remains unclear. This paper assesses the current debates surrounding nativism and mathematical knowledge by teasing them apart into two distinct claims. First, in what way does the experimental evidence from infants, nonhuman animals and neuropsychology support the nativist hypothesis? Second, granting that infants have some elementary mathematical skills, does this mean that such skills play an important role in the development of mathematical knowledge?     

Teachers’ implicit view of intelligence predict pupils’ self-perception as learners

Teachers regularly make judgements about their pupils’ intelligence while interacting with them in the classroom. The main aims of this paper are to analyse the structure of teachers’ judgements of their pupils’ intelligence, and to evaluate the influence that teachers have on pupils’ judgements of their own and their peers’ intelligence. Cross-cultural comparisons between English and Portuguese pupils are considered. In total 58 children 10- to 11-year-old and two teachers from London, UK and 47 children 5- to 6-year-old and two teachers from Lisbon, Portugal participated. The children completed aptitude tests and self-perception measures for general ability, reading and mathematical ability. The teachers ranked their pupils’ academic abilities from ‘best in the class’ to ‘weakest in the class’. Results show that teachers’ implicit conceptions of intelligence reflect a view of intelligence that is similar to what IQ tests measure. In addition the results support the notion that children’s verbal ability is more highly valued than mathematical ability. Moreover, the results also suggest that teachers have a considerable impact on their pupils’ self-perception as learners. Cultural differences are also discussed.     

Paternal Involvement with School-aged Children in Brazilian Families: Association with Childhood Competence

Thirty-eight middle- to lower-income Brazilian fathers in two-parent families provided estimates of different dimensions of their involvement with their school-aged children, assessed children’s social competence, and rated their beliefs on family roles. Analyses showed that fathers and mothers spent similar amounts of time in different activities with children, but did differ in didactic interactions, their responsibility for, and actually disciplining children. There were no significant differences in participation due to gender of child or income. Fathers’ ideological beliefs about gender roles were positively related to involvement in disciplining children and inversely related to engagement in social activities with children. Fathers’ involvement in disciplining children was negatively associated with childhood social competence after controlling for mothers’ contribution.     

Assessment of hormonal parameters and psychological well‐being in healthy subjects after a Taoist qigong program: An exploratory study

Qigong is an ancient form of health maintenance, which is part of Traditional China Medicine. Numerous beneficial mental and physical effects have been classically ascribed to this traditional psychosomatic method. The purpose of this work has been to assess the effects of Taoist qigong practice on several hormonal parameters of the Hipotalamic‐Pituitary‐Adrenal axis and specific measures of psychological well‐being in healthy subjects. Forty‐three healthy volunteers participated in the study, of whom 22 were randomly allocated to the experimental group, and 21 were assigned to the control group. Experimental participants underwent a qigong training program for one month. Blood samples for the quantification of hormonal parameters, and several instruments to assess anxiety and depression symptoms as well as subjective sleep quality, were obtained before and after the program. Statistically significant differences were found between the experimental and control groups, with the experimental group showing lower blood levels of adrenocorticotropic hormone (ACTH). This study shows that Taoist qigong is a psychosomatic method able to exert a modulatory action on ACTH levels in healthy subjects. We consider the need to continue exploring the psychobiological modulation of this qigong method and its possible repercussion for human health care.     

Less is more? Effects of exhaustive vs. minimal emotion labelling on emotion regulation strategy planning

Previous research suggests that labelling emotions, or describing affective states using emotion words, facilitates emotion regulation. But how much labelling promotes emotion regulation? And which emotion regulation strategies does emotion labelling promote? Drawing on cognitive theories of emotion, we predicted that labelling emotions using fewer words would be less confusing and would facilitate forms of emotion regulation requiring more cognitively demanding processing of context. Participants (N?=?82) mentally immersed themselves in an emotional vignette, were randomly assigned to an exhaustive or minimal emotion labelling manipulation, and then completed an emotion regulation strategy planning task. Minimal (vs. exhaustive) emotion labelling promoted higher subjective emotional clarity. Furthermore, in terms of specific emotion regulation strategies, minimal emotion labelling prompted more plans for problem solving and marginally more plans for reappraisal, but did not affect plans for behavioural activation or social support seeking. We discuss implications for the cognitive mechanisms supporting the generation of emotion regulation strategies.     

Supervenience of Extrinsic Properties

The aim of this paper is to define a notion of supervenience which can adequately describe the systematic dependence of extrinsic as well as of intrinsic higher-level properties on base-level features. We argue that none of the standard notions of supervenience—the concepts of weak, strong and global supervenience—fulfil this function. The concept of regional supervenience, which is purported to improve on the standard conceptions, turns out to be problematic as well. As a new approach, we develop the notion of property-dependent supervenience. This notion is founded on a criterion of relevance adapting the supervenience base to the considered higher-level properties in a specific way, such that only features which are relevant to the instantiation of the higher-level properties under consideration are taken into account.