Quantum information in an evolutionary perspective

An approach to quantum phenomena is reviewed that deals with the possibility of their realistic interpretation in the sense that they represent manifestations of hermeneutic circles between quantum “objects” and their experimental boundary conditions. Quantum cybernetics provides an evolutionary perspective in that all higher‐level organizations like molecules, cells, living systems, etc., can be discussed under one and the same systemic viewpoint: a hermeneutic circularity between a “core” (or “nucleus") and a relevant “periphery” (or “environment") which constitutes the systems’ organization and information potential.

Generally, in realistic theories, an individual quantum system is analyzable into a local “particle‐like” nonlinearity of a generally nonlocal “wave‐like” mode of some sub‐quantum structure of the vacuum ("Dirac ether"). In this view, a “particle” can be considered as being “guided” along one specific route by the (generally nonlocal) configurations of superimposed waves, which spread along all possible paths of an experimental setup. Moreover, in the approach of Quantum Cybernetics, an additional focus is given on the fact that the energy and momentum of a particle also determine the wave behavior. Thus, “waves” and “particles” are mutually and self‐consistently defined, and Quantum Cybernetics puts particular emphasis on the circular relationship—mediated by plane waves—between a quantum system and its macroscopically defined boundary conditions.     

A controlled trial of cognitive-behavior therapy combined with vestibular rehabilitation in the treatment of dizziness

Dizziness is a common and often untreated symptom in the general population. The aim of this study was to investigate the effects of a combined cognitive-behavioral/vestibular rehabilitation (VR) program, using a randomized control design. A total of 29 participants were randomized to treatment consisting of psychoeducation, vestibular exercises, relaxation and cognitive interventions, or to serve as waiting list controls. Measures of dizziness-related handicap, dizziness-provoking movements, and daily diary registrations of dizziness symptoms at pre- and post-treatment showed statistically significant improvements in many domains, which translated to moderate effect sizes. These findings provide preliminary support for the combination of Cognitive-behavioral therapy (CBT) and VR methods in the treatment of dizziness.     

Cognitive bias via the Internet: a comparison of Web-based and standard emotional Stroop tasks in social phobia

There is accumulating evidence to suggest that social phobia is associated with attentional bias for words related to social threat. Information processing in individuals with social phobia (n = 87) was investigated in the present study using 2 versions of the emotional Stroop task. Results from a standard emotional Stroop task indicated delayed colour naming of socially threatening words relative to neutral words, in line with previous research, whereas results from a Web-based emotional Stroop task indicated a facilitation effect, with faster manual indication of colour choice for socially threatening words than for neutral words. Possible explanations for these contrasting findings and issues for further research are discussed.     

In focus. Has patient autonomy gone to far? Geneticists' views in 36 nations

We surveyed genetics professionals, patients, and the public about rights to information, to requested services, and to parenthood, posing difficult cases found in practice. In all, 2906 genetics professionals (63%), 499 primary care physicians (59%), 476 North American genetics patients (67%), 394 French patients (51%), 593 German patients (65%), and 988 members of the American public (99%) returned anonymous questionnaires. Results suggest a trend toward increased respect for patient autonomy since an earlier survey in 1985; in most nations more would perform prenatal diagnosis for a couple with 4 daughters who desire a son. A minority (35% in U.S., 14% elsewhere) would perform PND for a deaf couple who want a deaf child, but most (94% in U.S., 62% elsewhere) would do prenatal paternity testing in the absence of rape or incest. About half (51%) would support a woman with fragile X who wants children. The trend to respect patient autonomy was greatest in the U.S. and was least evident in China and India. In general, responses to these cases illustrate a shift away from population or eugenic concerns to a model of genetics focused on the individual.     

Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse

The endogenous cannabinoid system has been shown recently to play a crucial role in the extinction of aversive memories. As the amygdala is presumably involved in this process, we investigated the effects of the cannabinoid receptor agonist WIN 55,212-2 (WIN-2) on synaptic transmission in the lateral amygdala (LA) of wild-type and cannabinoid receptor type 1 (CB1)-deficient mice. Extracellular field potential recordings and patch-clamp experiments were performed in an in vitro slice preparation. We found that WIN-2 reduces basal synaptic transmission and pharmacologically isolated AMPA receptor- and GABA_A receptor-mediated postsynaptic currents in wild-type, but not in CB1-deficient mice. These results indicate that, in the LA, cannabinoids modulate both excitatory and inhibitory synaptic transmission via CB1. WIN-2-induced changes of paired-pulse ratio and of spontaneous and miniature postsynaptic currents suggest a presynaptic site of action. Inhibition of G_i/o proteins and blockade of voltage-dependent and G protein-gated inwardly rectifying K⁺ channels inhibited WIN-2 action on basal synaptic transmission. In contrast, modulation of the adenylyl cyclase-protein kinase A pathway, and blockade of presynaptic N- and P/Q- or of postsynaptic L- and R/T-type voltage-gated Ca²⁺ channels did not affect WIN-2 effects. Our results indicate that the mechanisms underlying cannabinoid action in the LA partly resemble those observed in the nucleus accumbens and differ from those described for the hippocampus.     

Separating emotion and motivational direction in fear and anger: effects on frontal asymmetry

State effects on frontal alpha electroencephalograph asymmetry (ASY) are thought to reflect approach and withdrawal motivational tendencies. Although this motivational direction model has inspired a large body of research, efforts to disentangle influences of emotion (EMO) and motivational direction (MOT) on ASY are rare. The authors independently manipulated EMO (fear and anger) and MOT (approach and withdrawal) in a between-subjects design. Irrespective of MOT, anger led to greater changes toward relative left frontal activation (LFA) than did fear. Conversely, higher ratings of negative valence were associated with greater changes toward LFA in withdrawal but with greater changes toward relative right frontal activation in approach. Results are discussed within a model based on behavioral inhibition system-behavioral activation system theory.     

An irt-based model for dichotomous longitudinal data

The LLRA (linear logistic model with relaxed assumptions; Fischer, 1974, 1977a, 1977b, 1983a) was developed, within the framework of generalized Rasch models, for assessing change in dichotomous item score matrices between two points in time; it allows to quantify change on latent trait dimensions and to explain change in terms of treatment effects, treatment interactions, and a trend effect. A remarkable feature of the model is that unidimensionality of the item set is not required. The present paper extends this model to designs with any number of time points and even with different sets of items presented on different occasions, provided that one unidimensional subscale is available per latent trait. Thus unidimensionality assumptions within subscales are combined with multidimensionality of the item set. Conditional maximum likelihood methods for parameter estimation and hypothesis testing are developed, and a necessary and sufficient condition for unique identification of the model, given the data, is derived. Finally, a sample application is presented.To my friend Josef Roppert who has taught me how to apply statistical reasoning to substantive problems.This research was supported in part by Österreichische Forschungsgemeinschaft under grant No. 01/0054. The author wishes to thank B. Wild for the numerical computation of the sample application in section 5.     

Stress conceptions in life event research: Towards a person-centred perspective

The present article focuses on a discussion of the theoretical foundations of life event research. Since critical life events are usually regarded as stressful events, the main question is which concepts of stress are employed in different life event approaches and what is their rationale. The discussion centres on two topics that have to be treated independently: the question of specificity vs nonspecificity and the question of individualized vs normative weightings. It is shown that different life event approaches rely on different concepts of stress. Numerous objections lead to a rejection of the nonspecificity concept and a normative proceeding. However, even when a specificity view of stress is advocated and individual weights are used, life stress measures do not account for a substantial proportion of the variance in the stress-related dependent variables. Therefore, a reorientation of life event research is required. It is proposed that future life event research should concentrate on the individual meaning of events and adequately consider the time dimension as well CIS processes of coping.