Motor excitability is reduced prior to voluntary movements in children and adolescents with Tourette syndrome

Tourette syndrome (TS) is a neuro‐developmental disorder characterized by the occurrence of motor and vocal tics: involuntary, repetitive, stereotyped behaviours that occur with a limited duration, often typically many times in a single day. Previous studies suggest that children and adolescents with TS may undergo compensatory, neuroplastic changes in brain structure and function that help them gain control over their tics. In the current study we used single‐pulse and dual‐site paired‐pulse transcranial magnetic stimulation (TMS), in conjunction with a manual choice reaction time task that induces high levels of inter‐manual conflict, to investigate this conjecture in a group of children and adolescents with TS, but without co‐morbid Attention Deficit Hyperactivity Disorder (ADHD). We found that performance on the behavioural response‐conflict task did not differ between the adolescents with TS and a group of age‐matched typically developing individuals. By contrast, our study demonstrated that cortical excitability, as measured by TMS‐induced motor‐evoked potentials (MEPs), was significantly reduced in the TS group in the period immediately preceding a finger movement. This effect is interpreted as consistent with previous suggestions that the cortical hyper‐excitability that may give rise to tics in TS is actively suppressed by cognitive control mechanisms. Finally, we found no reliable evidence for altered patterns of functional inter‐hemispheric connectivity in TS. These results provide evidence for compensatory brain reorganization that may underlie the increased self‐regulation mechanisms that have been hypothesized to bring about the control of tics during adolescence.     

Early cognitive profiles of emergent readers: a longitudinal study

This longitudinal study examined the contribution of phonological awareness, phonological memory, and visuospatial ability to reading development in 142 English-speaking children from the start of kindergarten to the middle of Grade 2. Partial cross-lagged analyses revealed significant relationships between early performance on block design and matching letter-like forms tasks and later reading ability. Rhyme awareness correlated with later reading ability during the earliest stages, but onset awareness did not emerge as important until after the children had started reading. Digit span correlated significantly with future reading ability at every stage. These findings indicate that although phonological awareness, phonological memory, and visuospatial ability are all necessary for emergent reading, their relative importance varies across the first 2 years of reading development.     

Role of chromaticity, contrast, and local orientation cues in the perception of density

We compared the role of the red-green, blue-yellow, and luminance post-receptoral mechanisms in the perception of density. The task requires the comparison of densities between two stimuli composed of oriented bandpass elements, pseudo-randomly scattered across an area of constant size. The perception of density differences was measured by a temporal 2AFC procedure for all pairs of mechanisms and for four possible densities. We found that stimuli of identical physical densities are not perceived equally: there is a consistent bias in favour of blue-yellow stimuli which are perceived as significantly more dense than red-green and achromatic stimuli. We considered three factors that could have differentially affected the density perception of blue-yellow stimuli: an increase in the perceived size of the individual blue-yellow elements, a perceived contrast difference, and the presence of local orientation cues. We found that the increased perceived density of the blue-yellow stimuli occurred despite the fact that there was no increase in perceived size of the individual elements, and remained despite corrections for the two other factors. We conclude that the significant increase in perceived density for the blue-yellow mechanism is a global effect, associated with a perceived colour 'melting' of the elements in the array. Our data were fitted with the occupancy model of Allik and Tuulmets (1991, Perception & Psychophysics 49 303-314) and we found that blue-yellow stimuli have a greater 'occupancy' than red-green or achromatic stimuli.     

Blaming Drunk Victims: Is It Just World or Sex Role Violation?

Richardson and Campbell (1980, 1982), in studying attributions of blame and responsibility for violent interactions, found that intoxicated victims were blamed more and held more responsible for their victimization than their sober counterparts. Two alternative explanations were proposed to account for this finding: the just world hypothesis and the effects of sex role violation. The present study was designed to test these explanations. One hundred twenty-nine males and 93 females read scenarios that varied the sex of the victim and the level of intoxication of the victim and the aggressor. Participants rated the responsibility of the aggressor, victim, and situation for the action and evaluated the aggressor and victim. Although strong support for neither of the hypotheses was demonstrated, more support was found for the effect of sex role violation than for the just world hypothesis.     

A double-blind,sham-controlled,trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics,and suppression of the urge-to-tic,in individuals with Tourette syndrome and chronic tic disorder

Tourette syndrome (TS) and chronic tic disorder (CTD) are neurological disorders of childhood onset characterized by the occurrence of tics; repetitive, purposeless, movements or vocalizations of short duration which can occur many times throughout a day. Currently, effective treatment for tic disorders is an area of considerable unmet clinical need. We aimed to evaluate the efficacy of a home-administered neuromodulation treatment for tics involving the delivery of rhythmic pulse trains of median nerve stimulation (MNS) delivered via a wearable ‘watch-like’ device worn at the wrist. We conducted a UK-wide parallel double-blind sham-controlled trial for the reduction of tics in individuals with tic disorder. The device was programmed to deliver rhythmic (10 Hz) trains of low-intensity (1–19 mA) electrical stimulation to the median nerve for a pre-determined duration each day, and was intended to be used by each participant in their home once each day, 5 days each week, for a period of 4 weeks. Between 18th March 2022 and 26th September 2022, 135 participants (45 per group) were initially allocated, using stratified randomization, to one of the following groups; active stimulation; sham stimulation or to a waitlist (i.e. treatment as usual) control group. Recruited participants were individuals with confirmed or suspected TS/CTD aged 12 years of age or upward with moderate to severe tics. Researchers involved in the collection or processing of measurement outcomes and assessing the outcomes, as well as participants in the active and sham groups and their legal guardians were all blind to the group allocation. The primary outcome measure used to assess the ‘offline’ or treatment effect of stimulation was the Yale Global Tic Severity Scale–Total Tic Severity Score (YGTSS–TTSS) assessed at the conclusion of 4 weeks of stimulation. The primary outcome measure used to assess the ‘online’ effects of stimulation was tic frequency, measured as the number of tics per minute (TPM) observed, based upon blind analysis of daily video recordings obtained while stimulation was delivered. The results demonstrated that after 4-week stimulation, tic severity (YGTSS-TTSS) had reduced by 7.1 points (35 percentile reduction) for the active stimulation group compared to 2.13/2.11 points for the sham stimulation and waitlist control groups. The reduction in YGTSS–TTSS for the active stimulation group was substantially larger, clinically meaningful (effect size = .5) and statistically significant (p = .02) compared to both the sham stimulation and waitlist control groups, which did not differ from one another (effect size = −.03). Furthermore, blind analyses of video recordings demonstrated that tic frequency (tics per minute) reduced substantially (−15.6 TPM) during active stimulation compared to sham stimulation (−7.7 TPM). This difference represents a statistically significant (p < .03) and clinically meaningful reduction in tic frequency (>25 percentile reduction: effect size = .3). These findings indicate that home-administered rhythmic MNS delivered through a wearable wrist-worn device has the potential to be an effective community-based treatment for tic disorders.     

Sexually abused children and post-traumatic stress disorder

Sexually abused children often develop post-traumatic stress disorder, a distressing and debilitating condition that is typically unresponsive to non-directive counselling. Empirically supported abuse-confronting, structured interventions are urgently required for use by counselling psychologists responsible for the management of this challenging clinical population. Given the success of cognitive-behavioural interventions with adult trauma victims, it has been suggested that this treatment approach be applied to sexually abused children. This paper presents a cognitive-behavioural treatment framework comprising two levels of intervention: child therapy and parent training. We selectively review emerging empirical support for the efficacy and acceptability of this treatment approach.     

Convergent and discriminant validity of the Taylor and Buss measures of physical aggression

Although the Taylor and Buss paradigms have been the most widely used measures of human physical aggression, few attempts have been made to establish validity of the measures. The present investigation attempted to demonstrate convergent and discriminant validity of the paradigms. Fifty-five males engaged in five tasks designed to measure helping, competition, and aggression. Correlations computed among these measures lend support for convergent and discriminant validity of the Taylor and Buss paradigms.