Early Detection of Memory Impairment in Alzheimer’s Disease: A Neurocognitive Perspective on Assessment

We propose that the earliest neuropsychological detection of Alzheimer’s disease (AD) can be informed by current views about the neuropathogenesis of AD and cognitive models of memory and its neurobiological substrates. The primary impairment in early AD is encoding/consolidation, resulting from medial temporal lobe (MTL) pathology. On theoretical and empirical grounds, paired associate learning (PAL) appears to be the ideal paradigm for detecting MTL dysfunction in early AD. It has not been embraced as a test of choice, however, and this critical review discusses why the paradigm may have not fulfilled its potential. We suggest that a new PAL variant, ‘associate-recognition’, may prove to be clinically efficacious.     

Relative Cost Effectiveness of In-Person and Internet Interventions for Relationship Distress

While the efficacy of couple therapy has been repeatedly demonstrated, most distressed couples do not seek treatment. To improve reach and overcome barriers to therapy, Integrative Behavioral Couple Therapy (IBCT) was translated into a web-based program, OurRelationship (OR). While both IBCT and OR have been shown to improve relationship and individual functioning, the goal of the present study was to compare the relative cost effectiveness of these two treatment modalities. In IBCT, 74% of couples experienced reliable improvement, compared to 55% of couples in OR. Within-group Cohen's d effect sizes during treatment for relationship satisfaction were d = 0.87 for IBCT and d = 0.96 for OR. Relative cost effectiveness analyses revealed that even at the highest expense estimates for OR and the lowest expense estimates for IBCT, OR was more cost effective in creating reliable improvement once at least 229 couples were served and was more cost effective in creating large-size effects once at least 153 couples were served. Cost-effectiveness increases for both IBCT and OR as more couples are served; however, this cost savings occurs at a much more rapid rate for OR. These findings demonstrate that despite higher initial development costs, Internet programs are a cost-effective option for dissemination either as a stand-alone service or as an initial intervention in a stepped care model with more intensive in-person services.     

Prediction of childhood problems at three years in children experiencing disorders of regulation during infancy

The objective of this study was to determine if symptoms of regulatory disorder (RD) during infancy were related to clinical status at three years. Two age‐matched RD groups based on severity (N = 10 in mild RD group; N = 22 in moderate–severe RD group) and an age‐matched control group (N = 38) were evaluated at 7 and 30 months. A fourth group with pervasive developmental disorders (N = 18) also were tested. Problems with self‐regulation, including sleep, feeding, state control, self‐calming, sensory reactivity, mood regulation, and emotional and behavioral control, were documented during infancy. Children were retested at 36 months in their development, behavior, and play. Two child psychiatrists unfamiliar with the subjects' diagnostic classification during infancy provided diagnoses at 36 months. At 36 months, 60% of children with mild regulatory disorders did not meet criteria for any disorders, while 95% of infants with moderate regulatory disorders had diagnoses that fell into two diagnostic clusters: (1) delays in motor, language, and cognitive development and (2) parent–child relational problems. Most toddlers in the pervasive developmental disorder group were diagnosed as having PDD or autism with mental retardation or borderline intelligence at 36 months. Early symptoms are discussed as they relate to later diagnostic outcomes for the clinical samples. © 2000 Michigan Association for Infant Mental Health.     

Can Research on Women Be More Effective in Shaping Policy?

The potential usefulness of research on women's issues to the policymaking process is discussed in the context of the arguments both for and against trying to increase the policy utility of social science research in general. J. Weiss's concepts of „intrinsic,”„intellectual,” and „political usefulness” are presented and applied to specific policy issues of importance to women. The paper examines ways in which researchers could enhance the policy relevance of their research and ways in which the psychology establishment could encourage the development of policy-relevant research. The middle section of the paper describes the large array of roles and settings for social scientists in the federal policy structure, treating the executive, legislative, and judicial branches in turn. The history of and dilemmas created by the „Brandeis brief” are presented. The last section of the paper presents some important policy issues affecting women in the next five years and illustrates how one particular area of research could be made more useful.     

Interference Effects from Observed Movement in Parkinson's Disease

Previous research has demonstrated that Parkinson's disease patients have an increased susceptibility to response conflict. In the present study, the authors investigate whether Parkinson's patients have a similar sensitivity to interference from observed movements. In all, 10 patients and 10 controls performed horizontal and vertical arm movements while watching a video of either a person performing similar movements or a moving dot. Movements were performed in the same plane (congruent) and orthogonal to the observed movement (incongruent). The off-axis variance of movements was our index of interference. Although patients tended to exhibit more off-axis variability than did controls, both groups demonstrated similar congruence effects, with greater variance in incongruent conditions. These results indicated that increased susceptibility to interference in Parkinson's disease does not extend to interference from observed movements.     

Emotional and Behavioural Problems Among Refugee Children and Adolescents Living in South Australia

While there is a growing body of literature on the mental health status of adult refugees, children have been relatively neglected in research, particularly in Australia. This study investigated the prevalence of emotional and behavioural problems and patterns of service utilisation among 530 refugee children and adolescents aged 4–17 years living in South Australia. Parents and teachers of children aged 4–17 years and adolescents aged 13–17 years completed the appropriate versions of the Strengths and Difficulties Questionnaire. Of the 11.0% of children and adolescents found to have borderline or abnormal emotional and behavioural problems, only 13.0% accessed professional help. The study has practical implications for policy and practice.     

Sorrow,shame, and self-esteem: Perception of self and others in groups for women survivors of child sexual abuse

Despite evidence that exists about the severity of impact of child sexual abuse (CSA), less has been published about treatment options. Much CSA is enshrouded in secrecy in the context of dysfunctional family dynamics, therefore group work is often recommended as a method of treatment. Although long- and short-term groups are seen as being equally effective, there are few published studies of long-term analytic groups for survivors of CSA. This study was designed to analyse the process of one long-term group. A case is made for using Core Conflictual Relationship Theme (CCRT), a method designed to analyse individual therapy, with reference to group theory. Shifts in self-perception and in relation to others are analysed from the beginning to the end of therapy.     

An overview of the consumer-centric disruptive technology research: Insights from topic modelling and literature review

This review aims to assess the most prevalent disruptive technologies of the past decade and evaluate them from a dual perspective. This study utilises the technology life cycle framework to classify disruptive technologies into three phases, (i) emerging, (ii) industry, and (iii) customer-focused research outcomes. Subsequently, entities using six thematic categories via topic modelling are assessed to determine the research trajectory about customers, industries, and theory. The present study utilises the Latent Dirichlet Allocation framework for topic modelling, a quantitative tool that employs advanced statistical methodology to extract semantic knowledge from large text corpora. This approach offers a more comprehensive and insightful categorisation of information compared to traditional research review models such as archive review, meta-review analysis, and systematic literature review. After the review, over 750 articles were analysed and classified according to their unique themes and technological emphasis. The study suggests practical applications that could enhance industrial progress through disruptive technology. Furthermore, by identifying gaps, the authors suggest multiple research prospects for forthcoming investigations on disruptive technologies and their impact on consumer behaviour. This research is novel in various aspects. This research is by far the only research record in the last decade that provides a systematic literature review of disruptive technologies with an extensive focus on customers. Considering the methodological perspective, this research uses topic modelling as a new literature review model, enabling analysing more research outputs and yielding more valuable findings than traditional methodologies.     

Cognitive and neural determinants of response strategy in the dual-solution plus-maze task

Response strategy in the dual-solution plus maze is regarded as a form of stimulus-response learning. In this study, by using an outcome devaluation procedure, we show that it can be based on both action-outcome and stimulus-response habit learning, depending on the amount of training that the animals receive. Furthermore, we show that deactivation of the dorso-medial and the dorso-lateral striatum with Botulinum neurotoxin A, mimicked or abolished, respectively, the effects of practice on the sensitivity of the response strategy to outcome devaluation. These findings have relevant implications for the understanding of the learning mechanisms underlying different overt behaviors in this widely used maze task.     

Suicide, schizophrenia, and schizoid-type psychosis: role of life events and childhood factors

The first objective was to identify the provoking events of suicide in patients with schizophrenia or schizoid-type disorder, and to assess the humiliation component of these events. The second objective was to verify if quality of care during childhood is a vulnerability factor for suicide in patients with schizophrenia or schizoid-type psychosis. Thirty-three cases of suicide with a diagnosis of schizophrenia or schizoid-type psychosis were compared with 34 living patients with a similar diagnosis. The psychological autopsy method was used. The assessments were made with the Structured Clinical Interview for the Diagnostic and Statistical Manual for Axis I mental disorders, the Life Events and Difficulties Schedule, and the Child Experiences and Child Abuse Interview. The suicide group (SG) experienced more often a recent severe event, usually of a humiliation nature, than the control group (CG). It also experienced more severe events associated with aggressive behavior or with psychiatric impairment. Contrary to expectations, the CG had worse scores than the SG for quality of care during childhood. In conclusion, suicide in schizophrenia is related both to environmental stress and to psychiatric impairment.