Vagus nerve stimulation: a new form of therapeutic brain stimulation

Although the vagus nerve has traditionally been considered to perform efferent functions, in reality it performs significant afferent functions as well, carrying information from the body, head, and neck to the brain. Preliminary studies examining this afferent activity led to the theory that vagus nerve stimulation (VNS) could successfully control seizure activity in persons who are refractory to antiepileptic medications. Unlike other forms of brain stimulation, VNS is unable to directly stimulate multiple discrete areas of the brain; however, through several pathways, it is able to relay sensory information to higher brain regions. An implantable VNS device known as the VNSTM NeuroCybernetic Prosthesis (NCP) System has been used in approximately 9,000 epilepsy patients in Europe and the United States since 1994. The implant has reduced seizure frequency by an average of 25% to 30%, with minimal side effects. Studies underway are also showing some degree of success in the management of treatment-refractory depression. The future efficacy of the implantable system in other disorders may depend on whether the implant can be more precisely focused to affect different brain regions. Research in this area is underway.     

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Conclusion Wise counseling can relieve the anxiety and inner conflict of parents torn between the dread of their retarded offspring becoming a parent and the fear of an operation they believe to be illegal, immoral, and castrating.By knowing where to refer patients, clergymen can make it possible for some of these deprived members of society to find support and love within marriage without being overburdened by children they are not capable of rearing properly.     

Postural stability and hand preference as constraints on one-handed catching performance in children

Effects of postural state and hand preference as constraints on 1-handed catching performance were investigated in different ability groups of children aged 9-10 years. On the basis of pretest data, the authors classified 48 participants into groups of good, intermediate, and poor catchers (n = 16 in each) and asked them to perform 1-handed catches with their preferred and nonpreferred hands while standing and sitting. The good catchers' performance was not affected by the imposed postural constraints but did improve when they used the preferred hand. A similar effect of hand preference was evident in the intermediate and poor catchers, but there was also an effect of postural constraint. Independent of hand preference, intermediate catchers' performance while seated improved significantly compared with that during standing. For poor catchers, there was an interaction between hand preference and posture; significant improvement was evident only when they used the preferred hand in the sitting condition. The finding that manipulation of posture and hand preference affected performance outcomes indicates that perceptual skill is not the only influence on catching performance in children. Manipulation of those key constraints may facilitate the acquisition of catching skill, but more research is needed to determine the permanence of those effects.     

Self-enhancement among high-exposure survivors of the September 11th terrorist attack: resilience or social maladjustment?

The authors examined self-enhancing bias as a predictor of adjustment among individuals in or near the World Trade Center during the September 11, 2001, terrorist attacks. Resilience was defined from categorical and continuous analyses of both participant self-report and friend and relative ratings of adjustment. Self-enhancement was associated with a resilient outcome, ratings of better adjustment prior to September 11th, greater positive affect, and reduced perceptions of social constraints. Additional analyses indicated that self-enhancers' reduced symptom levels were fully mediated by their low perceived social constraints. However, consistent with previous evidence suggesting a social cost to self-enhancement, at 18 months post-September 11th, self-enhancers' friends and relatives also rated them as decreasing in social adjustment and as being less honest.     

Effect of orienting the finger opposition space in the control of reach-to-grasp movements

Participants (N = 13) made reach-to-grasp movements to an elongated object with or without a forearm pronation movement. Grasp and transport components of movements performed without forearm pronation differed from those performed when participants preplanned forearm pronation. The transport distance traveled after peak aperture (aperture closure distance) was unchanged, however, suggesting that participants initiated aperture closure on the basis of the distance of the hand from the target. When they suddenly pronated the forearm in response to a perturbation, aperture kinematics were altered from a monophasic to a biphasic profile and aperture closure distance was shortened. Conversely, a sudden reorientation to a nonpronated position minimized those changes. Thus, the relationship between transport and aperture components is differentially altered depending on online reorientation of the forearm.