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51.
Lesions of orbitofrontal cortex and basolateral amygdala complex disrupt acquisition of odor-guided discriminations and reversals 总被引:11,自引:1,他引:10 下载免费PDF全文
Schoenbaum G Setlow B Nugent SL Saddoris MP Gallagher M 《Learning & memory (Cold Spring Harbor, N.Y.)》2003,10(2):129-140
Recent work indicates that both orbitofrontal cortex (OFC) and the basolateral complex of the amygdala (ABL) are involved in processes by which cues are associated with predicted outcomes. To examine the respective roles of these structures in discrimination learning, rats with bilateral sham or neurotoxic lesions of either OFC or ABL were trained on a series of four 2-odor discrimination problems in a thirst-motivated go, no-go task. After acquisition of the series of odor problems, the rats were trained on serial reversals of the final odor problem. Performance on each problem was assessed by monitoring accuracy of choice behavior, and also by measuring latency to respond for fluid outcomes after odor sampling. During discrimination learning, rats in both lesioned groups had similar deficits, failing to show normal changes in response latency during learning, while at the same time exhibiting normal choice behavior relative to controls. Choice behavior was affected only during the reversal phase of training, in which OFC and ABL lesions produced distinctive deficits. Rats with ABL lesions were impaired on the first reversal (S1−/S2+), but were unimpaired at acquiring a reversal back to the original odor-outcome contigencies (S1+/S2−), whereas rats with OFC lesions were impaired on both types of reversals. These findings suggest that OFC and ABL serve partially overlapping roles in the use of incentive information that supports normal discrimination performance. 相似文献
52.
Previous studies have demonstrated that top-down factors can bias the storage of information in visual working memory. However, relatively little is known about the role that bottom-up stimulus characteristics play in visual working memory storage. In the present study, subjects performed a change detection task in which the to-be-remembered objects were organized in accordance with Gestalt grouping principles. When an attention-capturing cue was presented at the location of one object, other objects that were perceptually grouped with the cued object were more likely to be stored in working memory than were objects that were not grouped with the cued object. Thus, objects that are grouped together tend to be stored together, indicating that bottom-up perceptual organization influences the storage of information in visual working memory. 相似文献
53.
Phosphorescent square tiles (arranged to yield a single image size) were viewed in the dark by 56 monocular observers who utilized a chinrest. The targets were placed at one of three horizontal distances and at one of three eye heights, allowing us to study the relative effect of height in the visual field (HVF) and sagittal distance on observers' verbal reports of the horizontal distance at which the object lay (near, middle, or far). In Experiment 1, we found that reports covaried primarily with HVF and, as predicted, they exhibited a weak paradoxical inverse relation with horizontal distance. In a second and third experiment, a visible surface was placed under the targets at the three eye heights in both dark and fully lighted conditions. In this situation, the inverse distance relation disappeared, and HVF no longer influenced the judgments of most observers. The results show that information projected from relevant support surfaces is essential for veridical information about object distance. These results raise fundamental issues for perceptual researchers regarding how to decide when a cue has been properly delineated, given the assumption that the relation between a cue and what it specifies is probabilistic. 相似文献
54.
Four studies are described outlining the favorability of attitudes toward women. In Study 1, participants indicated their attitudes toward women and men and their construal of the term women. The results revealed that women were evaluated more favorably than men, but that male right-wing authoritarians (RWAs) who construed women as referring primarily to feminists were least favorable in their attitudes. In Study 2, participants indicated their attitudes toward both housewives and feminists. The results revealed that feminists were evaluated less favorably than housewives, and that the most negative attitudes toward feminists were expressed by authoritarian men. Study 3 revealed that high-RWA males held more negative symbolic beliefs concerning feminists (i.e., beliefs that feminists failed to promote participants'values) and that these beliefs accounted for variation in attitudes among high RWAs and much of the RWA-attitude relation. Finally, Study 4 revealed that high RWAs perceived greater value dissimilarity between them-selves and feminists. The implications of the findings for future research are discussed. 相似文献
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Multisystemic Therapy (MST) has been found to be effective in reducing youth antisocial behavior, but little is known about the process and impact of MST from the perspective of families themselves. This qualitative study explored parents' and young people's experiences of MST, focusing on aspects of the intervention that promoted or limited change. Thirty-seven semistructured interviews were conducted with a consecutive sample of 21 families (21 parent interviews, 16 young people) who had participated in a randomized controlled trial of MST for young offenders in the United Kingdom. Thematic analysis yielded 10 themes, organized into two domains: (a) engagement in MST and initial processes of change captures the central importance of the therapeutic relationship and the MST engagement model in families' positive experiences of MST; and (b) outcomes are complex reflects the range of positive outcomes reported (notably increased parental confidence and skills, improved family relationships, a return to education, and greater reflection and aspiration on the part of the young person) and mixed behavior outcomes. Even when the young person had reoffended, respondents indicated a range of other benefits for the family. The findings support the MST theory of change as well as point to some outcomes not usually measured in MST outcome studies. They also suggest some adaptations that may increase the impact of the intervention, including more attention to the influence of deviant peers, and ongoing support for families struggling to maintain strategies beyond the prescribed treatment period. 相似文献
58.
We propose that diversity is a malleable concept capable of being used either to attenuate or to enhance racial inequality. The research reported here suggests that when people are exposed to ambiguous information concerning an organization's diversity, they construe diversity in a manner consistent with their social-dominance motives. Specifically, anti-egalitarian individuals broaden their construal of diversity to include nonracial (i.e., occupational) heterogeneity when an organization's racial heterogeneity is low. By contrast, egalitarian individuals broaden their construal of diversity to include nonracial heterogeneity when an organization's racial heterogeneity is high. The inclusion of occupational heterogeneity in perceptions of diversity allows people across the spectrum of social-dominance orientation to justify their support for or opposition to hierarchy-attenuating affirmative-action policies. Our findings suggest that diversity may not have a fixed meaning and that, without a specific delineation of what the concept means in particular contexts, people may construe diversity in a manner consistent with their social motivations. 相似文献
59.
Delaney M Leroi I Simpson J Overton PG 《Journal of clinical psychology in medical settings》2012,19(3):338-346
Parkinson's disease (PD) is a progressive neurodegenerative disease primarily characterised by motor symptoms. However, another feature of PD which is receiving increasing attention is the phenomenon of impulse control disorders (ICDs), such as pathological gambling. To date, research into ICDs in PD has centred on a biomedical model of cause, related to the effects of dopamine replacement therapy. However, there are several areas of discrepancy in the current biomedical account of ICDs in PD. In addition, we argue that social and psychological factors also need to be considered to achieve a more complete understanding of the phenomenon. We present a novel conceptual model which combines biomedical and psychosocial factors in the genesis of ICDs in PD and use the model to identify a number of potential treatment intervention points and to highlight important outstanding questions concerning the inter-relationship between psychosocial and biomedical factors in the genesis of ICDs in PD. 相似文献
60.
Anne‐Lise Goddings Stephanie Burnett Heyes Geoffrey Bird Russell M. Viner Sarah‐Jayne Blakemore 《Developmental science》2012,15(6):801-811
The social brain undergoes developmental change during adolescence, and pubertal hormones are hypothesized to contribute to this development. We used fMRI to explore how pubertal indicators (salivary concentrations of testosterone, oestradiol and DHEA; pubertal stage; menarcheal status) relate to brain activity during a social emotion task. Forty‐two females aged 11.1 to 13.7 years underwent fMRI scanning while reading scenarios pertaining either to social emotions, which require the representation of another person’s mental states, or to basic emotions, which do not. Pubertal stage and menarcheal status were used to assign girls to early or late puberty groups. Across the entire sample, the contrast between social versus basic emotion resulted in activity within the social brain network, including dorsomedial prefrontal cortex (DMPFC), the posterior superior temporal sulcus, and the anterior temporal cortex (ATC) in both hemispheres. Increased hormone levels (independent of age) were associated with higher left ATC activity during social emotion processing. More advanced age (independent of hormone levels) was associated with lower DMPFC activity during social emotion processing. Our results suggest functionally dissociable effects of pubertal hormones and age on the adolescent social brain. 相似文献