Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo

We have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/ MAPK) is transiently activated in anatomically restricted regions of the lateral amygdala (LA) following Pavlovian fear conditioning and that blockade of ERK/MAPK activation in the LA impairs both fear memory consolidation and long-term potentiation (LTP) in the amygdala, in vitro. The present experiments evaluated the role of the ERK/MAPK signaling cascade in LTP at thalamo-LA input synapses, in vivo. We first show that ERK/MAPK is transiently activated/phosphorylated in the LA at 5 min, but not 15 or 60 min, after high-frequency, but not low-frequency, stimulation of the auditory thalamus. ERK activation induced by LTP-inducing stimulation was anatomically restricted to the same regions of the LA previously shown to exhibit ERK regulation following fear conditioning. We next show that intra-LA infusion of U0126, an inhibitor of ERK/MAPK activation, impairs LTP at thalamo-LA input synapses. Collectively, results demonstrate that ERK/MAPK activation is necessary for synaptic plasticity in anatomically defined regions of the LA, in vivo.     

Cognitive flexibility in preschoolers: the role of representation activation and maintenance

Preschoolers' lack of cognitive flexibility has often been attributed to perseverative processing. This study investigates alternative potential sources of difficulty such as deficits in activating previously ignored information and in maintaining currently relevant information. In Experiment 1, a new task tapping attentional switching was designed to isolate the difficulty of overriding an initial representation, that is, perseverative processing ('Perseveration' version), and the difficulty of activating a previously ignored representation, that is, activation deficit ('Activation-deficit' version). Three-year-olds' performance suggested that inflexibility may primarily stem from an activation deficit. Control experiments confirmed that the difficulty of the 'Activation-deficit' version could not be attributed to the effect of attraction to novelty. In Experiment 2, 'distraction' errors, alleged to reflect a failure to maintain a relevant representation, and 'perseverative' errors were distinguished. The results highlighted the important role of representation maintenance in flexibility. The present study indicates that preschoolers' lack of cognitive flexibility is multi-determined and prompts us to reconsider the role of perseveration.     

Testing for the presence of 1/f noise in continuation tapping data.

A number of recent papers have suggested that the series of time intervals produced in continuation tapping may have fractal properties. This proposition, nevertheless, was only based on the visual appraisal of graphical results, and was not statistically supported. In the present study, we applied the ARMA/ARFIMA modeling procedures proposed by Wagenmakers, Farrell, and Ratcliff (2005) to test for the presence of long-range dependencies in continuation tapping data. Our results demonstrate the presence of long-range dependencies in most series and offer strong support for the hypothesis that fluctuations in tapping series are fractal in nature.     

Feminism as a Radical Ethics? Questions for Feminist Researchers in the Humanities

A feminist perspective on selfhood – bound to a perspective on otherness – is the main concern of this article. The resonance of this notion of selfhood both with ethical philosophy and with the language of humanism enables a deeper understanding of a feminist ethics as well as its internal tensions. The article considers the relationship of feminism and humanism as one of “paradoxical fluidity” rather than antithetical polarization, to explore the ways in which feminism’s alliance with contemporary ethics exemplifies its paradoxical relation to humanism. The study then underlines the vital contribution of feminist discourse to an ethical understanding of selfhood and intersubjectivity. Finally, it examines the work of experimental Canadian poet Lola Lemire Tostevin, who reveals the importance of an ethical, feminist version of selfhood that highlights the insufficiency as well as the potential of both humanist and postmodern versions of subjectivity.     

A longitudinal assessment of executive function skills and their association with math performance.

The present study was designed to examine both concurrent and predictive associations between scores on a measure of executive function (EF) skills, the Contingency Naming Test (CNT), during the early school-age years. A secondary aim of the study was to examine the association between EF skills and mathematics performance. We administered tests of mathematics ability, and the CNT, to 178 children at ages 6 to 7, 8 to 9, and 10 to 11 years. From the CNT we obtained measures of response fluency/efficiency, working memory, and inhibition. The results demonstrate main effects of age on all CNT measures of EF, as anticipated, and inconsistent main effects of gender or mathematics learning disability status. Rates of improvement in EF varied as a function of the working memory demands present during a given task. There were differences in concurrent and predictive correlations for different CNT performance measures. EF scores obtained during the first assessment were as strongly associated with each other as they were with EF scores obtained four years later, suggesting a moderately stable source of individual differences on cognitive performance. EF scores at age 6 to 7 years were associated with concurrent and later mathematics scores, and most of these correlations were stronger than the significant associations found between response fluency on a baseline task (with no working memory demand) and mathematics performance. These findings have implications for the stability of EF skills during the school-age years, and the role of EF in early and later elementary school mathematics performance.     

Temperamental dimension and anxiety problems in a clinical sample of three- to six-year old children: a study of variables

In the last few years, many researchers have studied the presence of common dimensions of temperament in subjects with symptoms of anxiety. The aim of this study is to examine the association between temperamental dimensions (high negative affect and activity level) and anxiety problems in clinical preschool children. A total of 38 children, ages 3 to 6 years, from the Infant and Adolescent Mental Health Center of Girona and the Center of Diagnosis and Early Attention of Sabadell and Olot were evaluated by parents and psychologists. Their parents completed several screening scales and, subsequently, clinical child psychopathology professionals carried out diagnostic interviews with children from the sample who presented signs of anxiety. Findings showed that children with high levels of negative affect and low activity level have pronounced symptoms of anxiety. However, children with anxiety disorders do not present different temperament styles from their peers without these pathologies.     

Executive disorders and perceived socio‐emotional changes after traumatic brain injury

Although socio‐emotional changes are very frequently encountered after traumatic brain injury (TBI), the psychological mechanisms underlying these disorders are still poorly understood. This study aimed to explore the relationships between dysexecutive syndrome (assessed with the Behavioural Assessment of the Dysexecutive Syndrome [BADS]) and socio‐emotional changes assessed by the Iowa scales of personality change (ISPC) in patients with TBI. The BADS was thus administered to 25 patients with TBI and to 25 healthy controls. Simultaneously, a close relative of each patient was given the ISPC in order to assess socio‐emotional changes. Results indicated that patients displayed significantly lower executive performances than controls and experimented significant socio‐emotional changes. The Modified Six Elements Test was the only subtask of the BADS to be significantly related to behavioural changes, and more specifically to externalizing disorders. It is concluded that executive functions, and especially multitasking, encompass processes whereby one can consciously control one's emotional reactions and behaviours.     

Nonstandard career paths and profiles of commitment to life roles: A complex relation

The career paths (ascending, interesting, uninteresting, descending) of 124 White Canadian francophones (62 men, 62 women) who had experienced nonstandard and precarious work for the last three years were examined in relation to the participants’ profiles of commitment to three life roles (work, family, and duality, that is, investment in both career and family). The paths were derived from the content analysis of the data collected through semi-structured individual interviews. Quantitative tools were used to assess the importance of life roles and to compare the career paths as well as the commitment profiles with respect to specific and general anxiety. Among other results, a significant relationship was found between unsatisfying career paths and the duality profile, on the one hand, and higher levels of specific and general anxiety, on the other. The results are discussed with respect to the scientific literature. Implications for career counseling are suggested.     

Why is a truth-predicate like a pronoun?

I begin with an exposition of the two main variants of the Prosentential Theory of Truth (PT), those of Dorothy Grover et al. and Robert Brandom. Three main types of criticisms are then put forward: (1) material criticisms to the effect that (PT) does not adequately explain the linguistic data, (2) an objection to the effect that no variant of (PT) gives a properly unified account of the various occurrences of “true” in English, and, most importantly, (3) a charge that the comparison with proforms is explanatorily idle. The last objection is that, given a complete semantic account of pronouns, proadjectives, antecedents, etc., together with a complete (PT), the essential semantic character of “true” could be deduced, but then, the idleness of the comparison with pronouns would be apparent. It turns out that objections (2) and (3) are related in the following way: the prosentential terminology is held to conceal the lack of unity in (PT), by describing the different data in the same terms (“proform”, “antecedent”, etc.). But this, I argue, is only a way of truly describing, rather than explaining, the data, these being certain relations of equivalence and consequence between sentences. I consider a language for which (PT) would be not only true, but also explanatory, but note that this language is very different from English. I end by showing that Robert Brandom’s case that “is true” is not a predicate fails, and that his motivation for saying so is based on fallacious reasoning (namely, Boghossian’s argument against deflationism).     

A deflationary theory of reference

The article first rehearses three deflationary theories of reference, (1) disquotationalism, (2) propositionalism (Horwich), and (3) the anaphoric theory (Brandom), and raises a number of objections against them. It turns out that each corresponds to a closely related theory of truth, and that these are subject to analogous criticisms to a surprisingly high extent. I then present a theory of my own, according to which the schema “That S(t) is about t” and the biconditional “S refers to x iff S says something about x” are exhaustive of the notions of aboutness and reference. An account of the usefulness of “about” is then given, which, I argue, is superior to that of Horwich. I close with a few considerations about how the advertised theory relates to well-known issues of reference, the conclusions of which is (1) that the issues concern reference and aboutness only insofar as the words “about” and “refer” serve to generalise over the claims that are really at issue, (2) that the theory of reference will not settle the issues, and (3) that it follows from (2) that the issues do not concern the nature of aboutness or reference.