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Buchanan A Califano A Kahn J McPherson E Robertson J Brody B 《Kennedy Institute of Ethics journal》2002,12(1):1-15
Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. Before the benefits of pharmacogenetics can be realized, the ethical issues that arise in research and clinical application of pharmacogenetic technologies must be addressed. The ethical issues raised by pharmacogenetics can be addressed under six headings: (1) regulatory oversight, (2) confidentiality and privacy, (3) informed consent, (4) availability of drugs, (5) access, and (6) clinicians' changing responsibilities in the era of pharmacogenetic medicine. We analyze each of these categories of ethical issues and provide policy approaches for addressing them. 相似文献
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Body checking and avoidance and the core features of eating disorders among obese men and women seeking bariatric surgery 总被引:1,自引:0,他引:1
Grilo CM Reas DL Brody ML Burke-Martindale CH Rothschild BS Masheb RM 《Behaviour research and therapy》2005,43(5):629-637
This study examined two aspects of body checking and avoidance, and their relations to the core psychopathology of eating disorders (EDs), in severely obese men and women seeking bariatric surgery. A consecutive series of 260 (44 male and 216 female) gastric bypass candidates were administered measures to assess body checking and avoidance, binge eating, restraint, and overevaluation of weight and shape. The majority of patients reported regularly pinching areas of their body to check for fatness and avoided wearing clothing that made them particularly aware of their body. Significant associations were observed between checking and restraint, and between avoidance and binge eating. Both checking and avoidance behaviors were significantly associated with overevaluation of weight and shape. The positive associations between each of the two behaviors (body checking and avoidance) with overevaluation of weight/shape remained significant even after controlling for the effects of avoidance on body checking and vice versa. Stepwise multiple regression analyses revealed that binge eating, body checking, and avoidance behaviors made significant unique contributions and jointly accounted for 22-25% of the variance in overevaluation of weight and shape, respectively. This study documents the presence of eating disorder psychopathology among severely obese patients seeking bariatric surgery. The findings support the view that body checking and avoidance behaviors are manifestations of overevaluation of weight and shape and disordered eating. 相似文献
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The "difference position" holds that clinical research and therapeutic medical practice are sufficiently distinct activities to require different ethical rules and principles. The "similarity position" holds instead that clinical investigators ought to be bound by the same fundamental principles that govern therapeutic medicine--specifically, a duty to provide the optimal therapeutic benefit to each patient or subject. Some defenders of the similarity position defend it because of the overlap between the role of attending physician and the role of investigator in a research trial. This overlap is maximal when the same physician occupies both roles with respect to a particular patient-subject. We address the ethical tensions inherent in that role conflict and argue that the tensions are real but manageable. The difference position provides a sound ethical framework within which to manage those tensions, while the similarity position is unsatisfactory because it seeks to deny the existence of the tensions. 相似文献
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Lindsey Kirk Cindy Brody Ari Solomon David A. F. Haaga 《Journal of Rational-Emotive & Cognitive-Behavior Therapy》1999,17(4):237-248
This study compared perceptions of the causes of, therapies for, and means of coping with, depression between two groups of currently nondepressed adults: one with a history of major depression and one with no history of depression. Currently nondepressed participants were selected so that effects of past experience of depression could be distinguished from those of current mood. Recovered depressed participants (RD) (n = 25) and Never depressed participants (ND) (n = 25) recruited via newspaper advertisements completed self-report measures of (a) the perceived utility of either professional or self-help coping strategies for managing their own experiences of depression; (b) likely effectiveness of several major therapies for depression; and (c) perceived accuracy of several etiological theories of depression. RD participants rated depression as being less amenable to everyday self-help methods of coping and more in need of professional intervention. However, RD and ND subgroups did not differ significantly in their perceptions of the plausibility of etiological theories of depression in general, nor in their ratings of the likely helpfulness of major therapies. 相似文献
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Brody H 《The American journal of bioethics : AJOB》2006,6(4):51-3; discussion W42-5
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Gene A. Brewer Justin B. Knight Richard L. Marsh Nash Unsworth 《Memory & cognition》2010,38(3):304-311
The multiprocess view proposes that different processes can be used to detect event-based prospective memory cues, depending
in part on the specificity of the cue. According to this theory, attentional processes are not necessary to detect focal cues,
whereas detection of nonfocal cues requires some form of controlled attention. This notion was tested using a design in which
we compared performance on a focal and on a nonfocal prospective memory task by participants with high or low working memory
capacity. An interaction was found, such that participants with high and low working memory performed equally well on the
focal task, whereas the participants with high working memory performed significantly better on the nonfocal task than did
their counterparts with low working memory. Thus, controlled attention was only necessary for detecting event-based prospective
memory cues in the nonfocal task. These results have implications for theories of prospective memory, the processes necessary
for cue detection, and the successful fulfillment of intentions. 相似文献