Muscarinic cholinergic receptor blockade in the rat prelimbic cortex impairs the social transmission of food preference

Previous findings demonstrate the involvement of the cholinergic NBM in the acquisition of the social transmission of food preference (STFP), a relational associative odor-guided learning task. There is also evidence that muscarinic receptors in the medial prefrontal cortex, an important NBM target area, may modulate olfactory associative memory. The present experiment determined the consequences of blocking muscarinic cholinergic receptors in a component of the medial prefrontal region (the prelimbic cortex) on the STFP task. Adult male Wistar rats were bilaterally infused with scopolamine (20 microg/site) prior to training and showed a severe impairment in the expression of the task measured in two retention sessions, both immediately and 24h after training. Local scopolamine injections in the prelimbic cortex did not affect other behavioral measures such as olfactory perception, social interaction, motivation to eat, neophobia, or exploration. Results suggest that muscarinic transmission in the prelimbic cortex is essential for the STFP, supporting the hypothesis that ACh in a specific prefrontal area is important for this naturalistic form of olfactory relational memory. Current data are discussed in the context of disruption of learning as a result of interferences in PLC functions such as behavioral flexibility, attention, and strategic planning.     

Effects of parafascicular excitotoxic lesions on two-way active avoidance and odor-discrimination

To investigate whether the parafascicular (PF) nucleus of the thalamus is involved in different learning and memory tasks, two experiments were carried out in adult male Wistar rats that were submitted to pre-training bilateral N-methyl-d-aspartate PF infusions (0.15M, pH 7.4; 1.2 microl/side, 0.2 microl/min). In Experiment 1, we evaluated the effects of PF lesions in two identical 30-trial training sessions, separated by a 24-h interval, of a two-way active avoidance conditioning. PF-lesioned rats exhibited impaired performance in both sessions, measured by number of avoidance responses. In Experiment 2, the effects of PF lesions were assessed in a training session (5 trials) and a 24-h retention test (2 retention trials and 2 relearning trials) of an odor-discrimination task. PF lesions did not significantly disrupt the acquisition or the first retention trial, which was not rewarded. However, lesioned animals' performance was clearly affected in subsequent trials, following the introduction of the single non-rewarded trial. Current data are discussed considering evidence that lesions of the PF nucleus affect learning and memory functions mediated by anatomically related areas of the frontal cortex and striatum.     

Intention to learn influences the word frequency effect in recall but not in recognition memory

Watkins, LeCompte, and Kim (2000) suggested that the recall advantage for rare words in mixed lists is due to a compensatory study strategy that favors the rare words. They found the advantage was reversed when rare and common words were studied under incidental learning conditions. The present study investigated the possibility that the rare-word advantage in recognition memory is also the result of a compensatory study strategy. Experiment 1 replicated the findings of Watkins et al. that the rare-word advantage in recall is eliminated under incidental learning conditions. In contrast, Experiment 2 showed that the rare-word advantage in recognition memory is maintained under both intentional and incidental learning conditions. Experiment 3 replicated the results of Experiments 1 and 2 using different stimuli and a different orienting task. Finally, Experiment 4 showed that the rare-word advantage in recognition is maintained with pure lists. These findings show that the rare-word advantage in recognition memory is not the result of a compensatory study strategy. Instead, rare words are encoded more distinctively than common words, irrespective of participants' intention to remember them.     

When mirrors lie: “Visual capture” of arm position impairs reaching performance

If we stand at a mirror’s edge, we can see one half of our body reflected in the mirror, as if it were the other half of our body, seen “through” the mirror. We used this mirror illusion to examine the effect of conflicts between visually and proprioceptively specified arm positions on subsequent reaching movements made with the unseen right arm. When participants viewed their static left arm in the mirror (i.e., as if it were their right arm), subsequent right-arm reaching movements were affected significantly more when there was conflict between the apparent visual and the proprioceptively specified right-arm positions than when there was no conflict. This result demonstrates that visual capture of arm position can occur when individual body parts are viewed in the mirror and that this capture has a measurable effect on subsequent reaching movements made with an unseen arm. The result has implications for how the brain represents the body across different sensory modalities.     

When "minimal risk" research yields clinically-significant data, maybe the risks aren't so minimal

Surveys and routine clinical procedures applied in research protocols are typically considered only minimally risky to participants. The apparent benign nature of "minimal risk" tasks increases the chance that investigators and Institutional Review Boards (IRBs) will overlook the probability that clinical tools will identify signs, symptoms, or definitive test results that are clinically-relevant to subjects' welfare. "Minimal risk" procedures may also pose a particular hazard to participants in clinical research by increasing the therapeutic misconception because the tasks mimic clinical care and are often conducted in clinical settings. Investigators should anticipate which measures could yield clinically-important findings and should describe explicit plans for data monitoring, disclosure, and follow-up. Protocols that include reliable and valid clinical measures should prompt a more detailed risk assessment by the IRB, even when the tasks meet the regulatory criteria for minimal physical, psychological, or emotional risk.     

Dysfunctional beliefs in panic disorder: The Panic Belief Inventory

The Panic Belief Inventory (PBI) was developed to assess beliefs that increase the likelihood of catastrophic reactions to physical and emotional experiences in panic disorder. In the first stage of scale development, 197 panic disorder patients completed the PBI and standard self-report inventories of psychiatric symptomatology. An exploratory factor analysis yielded a 4-factor solution from which a 35-item instrument with 4 scales was constructed. The shortened measure and its scales had good internal consistency and convergent validity and moderate discriminant validity. Subsequently, 22 panic disorder patients who received cognitive therapy completed the PBI and other self-report inventories of dysfunctional cognitions at intake, 4 weeks, 8 weeks, termination, and several follow-up intervals. Results indicated that the PBI decreased significantly across treatment, with the largest decline occurring between intake and 4 weeks into treatment. The PBI correlated more strongly with dysfunctional cognitions associated with anxiety than dysfunctional cognitions associated with depression. These results provide preliminary evidence that the PBI has adequate psychometric characteristics, is useful to assess change in dysfunctional beliefs during treatment, and has the potential to advance cognitive theories of panic.     

Passion, Pain, and Purpose: One Man’s Response to the Passion of the Lord

The purpose of this article is to review and comment on the book The Passion of the Lord: African American Reflections. Edited by James A. Noel and Matthew V. Johnson, and published by Facets (an imprint of Fortress Press: Minneapolis), the book explores the unique perspective of African American thought in relation to the story of the Passion of Christ, and the cultural aesthetics which allow Christ’s suffering on the cross to become a powerful agent of spiritual strength, hope, love, and faith. This article records one African American man’s deep personal engagement of, and resonance to, the material as he validates, affirms the important insights of the seven theologians presented. Through personal observation and experience, poetry and relevant cultural idioms, the author honors work which, ultimately, contributes to a vitally important self-understanding of who African Americans are now, where they are now, and how they have come to be the people they are now in America.

The Short Mood and Feelings Questionnaire (SMFQ): A Unidimensional Item Response Theory and Categorical Data Factor Analysis of Self-Report Ratings from a Community Sample of 7-through 11-Year-Old Children

Item response theory (IRT) and categorical data factor analysis (CDFA) are complementary methods for the analysis of the psychometric properties of psychiatric measures that purport to measure latent constructs. These methods have been applied to relatively few child and adolescent measures. We provide the first combined IRT and CDFA analysis of a clinical measure (the Short Mood and Feelings Questionnaire—SMFQ) in a community sample of 7-through 11-year-old children. Both latent variable models supported the internal construct validity of a single underlying continuum of severity of depressive symptoms. SMFQ items discriminated well at the more severe end of the depressive latent trait. Item performance was not affected by age, although age correlated significantly with latent SMFQ scores suggesting that symptom severity increased within the age period of 7–11. These results extend existing psychometric studies of the SMFQ and confirm its scaling properties as a potential dimensional measure of symptom severity of childhood depression in community samples.     

Early mother-infant interaction and factors negatively affecting parenting

The social information-processing model contributes to identifying the psychological processes underlying the construct "sensitivity" in early mother-child interaction. Negative emotional states associated with inadequate self-regulation in coping with stressors affect the mother's attention skills and the processing of the baby's signals. This leads to less synchronous parental practices, particularly unsatisfactory when the baby is unhappy, or crying because the required self-regulation is not provided. This micro-social research studies the sequential profile of maternal reactions to the baby's positive/neutral vs. difficult behaviours and compares them in two groups of dyads, one with mothers who reported high levels of distress and other negative factors for parenting and another group with low levels. The unfavourable circumstances of the high stress group and their negative effects on interaction were observed in some indiscriminate maternal responses and particularly as they reacted to their baby's difficult behaviour, when the mother's regulatory role is more necessary.