How I Attend—Not How Well Do I Attend: Rethinking Developmental Frameworks of Attention and Cognition in Autism Spectrum Disorder and Typical Development

Evidence from the study of attention among persons with autism spectrum disorder (ASD) and typically developing (TD) children suggests a rethinking of the notion that performance inherently reflects disability, ability, or capacity in favor of a more nuanced story that involves an emphasis on styles and biases that reflect real-world attending. We provide examples from behavioral and physiological research in which performance on attention tasks is not solely a function of abilities, or disabilities, per se but rather is also a function of the ways in which they are implemented. Thus, the study of attention both among persons with ASD and in typical development might best be recast in terms of the question of “how” rather than “how well.”     

Associations of Quality of Life,Physical Activity and Mood States in Women with Breast Cancer Treated with Curative Intent

This study aims to investigate the associations between quality of life, physical activity and mood states in women with breast cancer. A total of 354 women (mean age, 51.74?±?8.63 years; body mass index (BMI), 28?±?5.67 kg/m²) completed the Baecke Physical Activity Questionnaire, Profile of Mood States (POMS), European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) and European Organisation for Research and Treatment of Cancer Breast Cancer-Specific Quality of Life Questionnaire (EORTC QLQ-BR23). Pearson’s correlation and multiple linear regressions were used to verify the relations between outcomes and independent variables. Correlations between scores on POMS, Baecke Physical Activity Questionnaire and global health status/quality of life subscale of EORTC QLQ-C30 found associations (p?<?0.01) between physical activity (r?=?0.191), vigour (r?=?0.333) and fatigue (r?=??0.433). Multiple linear regression analysis of the global health status/quality of life subscale of the EORTC QLQ-C30 showed significant differences for vigour (p?<?0.001), social function (p?=?0.003), side effects of systemic therapy (p?=?0.019), arm and breast symptoms (p?<?0.001) and Baecke physical activity score (p?=?0.006). Physical activity is an independent factor related to the quality of life in women with breast cancer. Understanding these variables may influence clinical decisions during treatment and allow positive interventions regarding symptoms, functions and lifestyle.     

Varieties of Epistemic Freedom

When we deliberate about what to do, we appear to be free to decide on different options. Three accounts use ordinary beliefs to explain this apparent freedom—appealing to different types of ‘epistemic freedom’. When an agent has epistemic freedom, her evidence while deliberating does not determine what decision she makes. This ‘epistemic gap’ between her evidence and decision explains why her decision appears free. The varieties of epistemic freedom appealed to might look similar. But there is an important difference. Two rely on an agent's ability to justifiably form beliefs unconstrained by evidence, and identify decisions as beliefs—either beliefs about acts (Velleman) or about decisions (Joyce and Ismael). But, when used to explain apparent freedom, these accounts face serious problems: they imply that agents have epistemic freedom over evidence-based beliefs, and rely on a faulty notion of justification. Underlying these troubles, it turns out that these accounts presuppose an unexplained apparent ability to form different beliefs. A third variety of epistemic freedom uses ignorance conditions instead (Levi and Kapitan). We appear free partly because we're ignorant of what we'll decide. Ignorance-based accounts avoid the above problems, and remain a promising alternative.     

Solidification thermal parameters,microstructural evolution and dendritic growth in an AlCuNi alloy

ABSTRACT

Unsteady-state upward solidification experiment was carried out with the Al-3Cu-3Ni (wt.%) alloy. Temperature profiles were obtained through a water-cooled directional solidification device. Analysis on the resulting as-cast microstructure and its adaptation to thermal solidification parameter, such as growth and cooling rates and solidification local time, V_L, T_R and t_SL, respectively, was carried out. The results showed that the resulting microstructure is constituted by an Al-rich primary phase (Al _α ), characterised by a dendritic network, and by second phases that take place within the interdendritic regions, forming a eutectic mixture composed by the β-Al₃Ni?+?θ-Al₂Cu intermetallic compounds (IMCs), whose size and morphology have been affected by V_L and T_R. The length of the microstructural scale of the Al _α phase was measured by the secondary dendritic spacing (λ ₂). The experimental mathematical expression of λ ₂ obtained in this work was compared with mathematical models proposed in the literature that associate t_SL-λ ₂ for non-equilibrium and equilibrium solidification conditions.     

High level swimming performance and its relation to non-specific parameters: a cross-sectional study on maximum handgrip isometric strength

The relationship between handgrip isometric strength and swimming performance was assessed in the four competitive swimming strokes in swimmers of different age groups and of both sexes. 78 national-level Portuguese swimmers (39 males, 39 females) were selected for this study. Grip strength, previously used as a marker of overall strength to predict future swimming performance, was measured using a hand dynamometer. The best competitive time at 100 and 200 m in all four swimming strokes were converted into 2010 FINA points. Non-parametric tests were used to evaluate differences between groups. Pearson product-moment correlations were computed to verify the association between variables. Handgrip maximum isometric strength was significantly correlated with swimming performance, particularly among female swimmers. Among female age group swimmers, the relationship between handgrip and 100-m freestyle was significant. Handgrip isometric strength seems to be related to swimming performance, especially to 100-m freestyle and in female swimmers. For all other distances and strokes, technique and training probably are more influential than semi-hereditary strength markers such as grip strength.     

A planner agent that tries its best in presence of nondeterminism

In many nondeterministic planning domains, an agent whose goal is to achieve φ may not succeed in finding a policy that can guarantee that all paths from the initial state lead to a final state where φ holds (strong solution). Nevertheless, if the agent is trying its best to achieve φ, it cannot give up. Instead, it may be inclined to accept weaker guarantees, such as having a path leading to φ from any intermediate state reached by the policy (strong-cyclic solution), or even less, such as having at least one path leading to φ from the initial state (weak solution). But the agent should choose among such different options based on their availability in each situation. Although the specification of this type of goal has been addressed before, in this paper we show how a planner based on the branching time temporal logic α-ctl can be used to plan for intuitive and useful goals of the form “try your best to achieve φ”.     

Strategic differentiation and integration among the 50 states of the USA

Recent studies demonstrate that individuals and populations (at the scale of nations) exhibiting slower life history (LH) speeds are more differentiated amongst themselves with respect to the components of life history. Faster life history individuals and populations are more integrated by comparison. This phenomenon, termed strategic differentiation–integration effort (SD–IE), has not yet been tested on a national scale, however, which is an important remaining step in establishing its generalizability at different levels of aggregation among humans. SD–IE was tested with data on five LH variables from the fifty states of the US. Effects supportive of the SD–IE hypothesis were found in all LH variables, with an average effect magnitude slightly larger than that found in studies of SD–IE at the individual differences level. This is putatively attributed to population stratification, due to the varied racial make-up of the population in the US, including European, African, Native American, and Asian ancestries from multiple countries. This study indicates that SD–IE is a generalizable phenomenon occurring at various levels of aggregation.     

Sleep deprivation effects on object discrimination task in zebrafish (<Emphasis Type="Italic">Danio rerio</Emphasis>)

The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition.     

Development of an evaluation scale for sitting and standing from the ground for children with Duchenne muscular dystrophy

The authors developed an evaluation scale for sit-stand from the ground for children with Duchenne muscular dystrophy (DMD) and tested its reliability. The construction occurred in stages: (a) the characterization of the movement in healthy children, (b) the characterization of the movement in children with DMD, (c) the elaboration of the 1st version of the scale and the manual, (d) the evaluation by experts and readjustments, and (e) the analysis of inter- and intraexaminer reliability and correlation with the Vignos Scale, age, and time for the execution of the activity. The scale comprehended 3 phases for sitting and 5 for the standing. A very good repeatability of the measures of sitting and standing (ICC = 0.89 and 0.84, respectively) and excellent reproducibility (ICC = 0.93 and 0.92, respectively) was demonstrated. The Kappa coefficient for the 8 phases in the interexaminer analysis varied from 0.77 to 1.00 (excellent reliability), and in the intraexaminer analysis varied from 0.80 to 1.00 (excellent reliability). Good correlation was found between the variables on the Vignos Scale (age: r = 0.58; stand: r = 0.56). The scale is a reliability instrument that allows evaluation of the activity of sitting and standing in children with DMD.