Competing interests: The need to control conflict of interests in biomedical research

Individual and institutional conflict of interests in biomedical research have becomes matters of increasing concern in recent years. In the United States, the growth in relationships — sponsored research agreements, consultancies, memberships on boards, licensing agreements, and equity ownership — between for-profit corporations and research universities and their scientists has made the problem of conflicts, particularly financial conflicts, more acute. Conflicts can interfere with or compromise important principles and obligations of researchers and their institutions, e.g., adherence to accepted research norms, duty of care to patients, and open exchange of information. Disclosure is a key component of a successful conflict policy. Commitments which conflict with a faculty member's primary obligations to teaching, research, administrative responsibilities, or patient care also need attention. Institutional conflict of interests present different problems, some of which are discussed in an analysis of an actual problem posed by two proposed clinical trials. This paper is adapted from a lecture presented to a Symposium on Scientific Integrity, Warsaw, Poland, 23 November 1995. Daniel Steiner was Vice-President and General Counsel of Harvard University (1972–92) and in that capacity became familiar with conflict of interest issues. He is currently Counsel to the Boston law firm. Ropes and Gray, and is Adjunct Lecturer in Public Policy at the John F. Kennedy School of Government. Harvard University.     

Laboratory functions for the Tecmar Lab Tender and IBM PC

A set of assembly language functions has been written to interface laboratory software for the IBM PC to the Tecmar, Inc., Lab Tender circuit board. These functions provide convenient access to the Lab Tender’s parallel ports, timers, A/D converters, and D/A converters from laboratory control programs written in the C language.     

Help Seeking: Effects of Visibility of Task Performance and Seeking Help

This study manipulated independently whether help seeking and task performance were public or private, since in public settings persons may lose esteem by seeking help or by demonstrating unsuccessful performance. Subjects were given false feedback that they were doing poorly on a task involving judging levels of neuroticism in others, and were given all opportunity to seek help by consulting a set of guidelines. The main result was an interaction with help seeking most likely when task performance was public and help seeking was private.     

Vocational role choice in second- and sixth-grade children

In a replication of two investigations reported by Looft (1971a, 1971b), 40 second- and sixth-grade male and female students were interviewed concerning their desired and expected vocational aspirations. In contrast to Looft's findings, no significant sex differences were found for either grade level in (a) the number of different (nonoverlapping) vocations nominated or (b) the number of subjects changing initial vocational role choices. When the issue of traditionality of vocational choice (i.e., vocations socially identified with the sex of the subject) was examined, it was found that half of the sixth-grade females interviewed nominated nontraditional vocations (e.g., basketball player, police officer). It was observed further that males in both the second- and sixth-grade samples overwhelmingly nominated traditional vocations. Contrary to Looft's interpretation, the findings suggest that although goals associated with the women's liberation movement (e.g., changes in sex-role expectations) are not demonstrated clearly in the vocational aspirations or expectations of young children, they may be reflected in the aspirations of adolescent females.     

Beauty Is Only "Name" Deep: The Effect of First-Name On Ratings of Physical Attraction

College students ( n = 197) voted to select a beauty queen from among six photographs equivalent in physical attractiveness, as determined by rankings of 35 students from a separate university. Half the photographs bore a desirable first-name and half were assigned an undesirable first-name. As predicted, firstname had a significant effect on physical attraction: Girls with desirable firstnames received 158 votes to 39 for those with undesirable names. These data were discussed in terms of an additive, rather than an interactive, effect, due to the nature of the task. The strength of these findings was related to the study's ecological validity.     

Picture superiority in free recall: The effects of organization and elaboration

A conception of semantic memory structure is presented in which elaboration is considered to vary both between and within items. Pictures and their verbal labels are suggested to activate common abstract memory representations, but these activations will differ in their degree of within-item elaboration. However, pictures and words should show comparable between-item elaboration properties, such as might be revealed by the category-recall relationship and clustering in free recall. Children were presented pictures and words in either a category-recall situation, where between-item elaboration was emphasized, or in a control situation where between-item elaboration was minimized. No differences between pictures and words in either recall or clustering were found in the category-recall task. However, when the same items were presented in the control situation the typical picture superiority effect in free recall was found. The results are interpreted as consistent with a two-factor theory of semantic elaboration, and indicate that these basic properties of memory encoding hold even for young children.     

Technology transfer at Harvard University

This memorandum was prepared by Daniel Steiner, General Counsel to Harvard University on behalf of the President's Office and distributed to the faculty in October, 1980. It reviews recent Harvard policy with regard to patents and technology transfer. Spurred by recombinant DNA research, at Harvard and elsewhere, benefits and pitfalls of the University's participation as a minor shareholder in a company engaged in research and development are identified. The author notes that “The memorandum has benefited from numerous discussions with members of the faculty and administration and in particular from the comments of President (Derek) Bok and Dean (Henry) Rosovsky.”     

Asymmetric attributions for compliance: Reward vs punishment

It was proposed that people attribute an individual's behavior more to internal factors when that individual's actions are influenced by reward than when those actions are influenced by punishment. Previous research has failed to control for the power of reward versus punishment which, in effect, creates a confounding of behavioral base rates (consensus) with the reward-punishment manipulation. The current research created reward and punishment contingencies that were equal in their base rates for producing a compliant response. In Experiment 1, subjects (n = 63) who produced the base-rate data also made attributions regarding a compliant target person. The results supported the reward-punishment attributional asymmetry hypothesis in that the target person was held more responsible for his actions in the reward than in the punishment conditions. A second experiment (n = 72) provided some attributors with information regarding base rates for compliance and measured perceived base rates for compliance. Knowledge of the base rates for compliance eliminated the reward-punishment attributional asymmetry phenomenon. Subjects not provided with such knowledge erroneously assumed different base rates for reward and punishment and maintained the perception of reward-punishment attributional asymmetry. Using subjects' estimates of base rate for compliance as a covariate eliminated the attributional asymmetry effect. It is suggested that erroneous base-rate assumptions mediate the attributional asymmetry phenomenon.