Family History and APOE-4 Genetic Risk in Alzheimer’s Disease

Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.     

Assessing Patients’ Beliefs About Their Cancer-Related Fatigue: Validation of an Adapted Version of the Illness Perception Questionnaire

Cancer-related fatigue (CRF) is a common and distressing side-effect of cancer treatment. The present study developed a brief version of the Illness Perception Questionnaire (IPQ) for assessing patients' representations of CRF. Cancer patients and survivors (n?=?155) completed a revised version of the IPQ as well as measures of fatigue severity at two different time-points. Confirmatory factor analysis at both Time 1 and 2 showed that the seven-factor solution based on the Self-Regulation Model fit the data adequately and factorial invariance over the two time-points was supported. The resulting subscales exhibited good internal consistency and test-retest reliability. The adapted version of the IPQ shows promise for the assessment of patient perceptions regarding CRF. The scale may be able to be used clinically to identify if patients have inaccurate or unhelpful representations of CRF and to help tailor interventions for persistent fatigue in cancer survivors.     

Internalization of the thin and muscular body ideal and disordered eating in adolescence: the mediation effects of body esteem

This study investigates body esteem factors (weight-esteem and appearance-esteem) as mediators of the relationship between ‘internalization of the ideal body figure’ and disordered eating behaviors (restrained, emotional and external eating) in a community sample of adolescent males (n = 810) and females (n = 1137) from the Ontario Research on Eating and Adolescent Lifestyles (REAL) study. Mediation models were examined using a bootstrapping approach to test indirect effects and indirect contrasts. In males, weight-esteem partially mediated the relationship between muscular ideal and restrained eating; appearance-esteem partially mediated effects in the emotional and external eating regressions. In females, both weight-esteem and appearance-esteem partially mediated the relationship between thin ideal and all three forms of disordered eating; weight-esteem was a stronger mediator for restrained eating, and appearance-esteem a stronger mediator for emotional and external eating. Body esteem is important to consider for prevention and treatment of disordered eating in both genders.     

FOXP2 in focus: what can genes tell us about speech and language?

The human capacity for acquiring speech and language must derive, at least in part, from the genome. In 2001, a study described the first case of a gene, FOXP2, which is thought to be implicated in our ability to acquire spoken language. In the present article, we discuss how this gene was discovered, what it might do, how it relates to other genes, and what it could tell us about the nature of speech and language development. We explain how FOXP2 could, without being specific to the brain or to our own species, still provide an invaluable entry-point into understanding the genetic cascades and neural pathways that contribute to our capacity for speech and language.     

The Early Lives of Highly Creative Persons: The Influence of the Complex Family

Over the last 50 years, theoretical, speculative, and empirical scholarship has examined the influence of early family context on subsequent accomplishments in children of high ability. Building upon 40 years of creativity literature focusing on optimal experience, this exploratory study applied the Complex Family Framework in a systematic analysis of creative adults' recollections of their early family lives. The study identifies evidence of the interplay of Integration and Differentiation, a catalyst for individual optimal experience, in the families of 9 creative exemplars who have made significant contributions to contemporary culture. Five participants represented the Arts and Humanities, three the Social Sciences, and one the Physical Sciences. The study demonstrates the utility of the Complex Family Framework in understanding families' contributions to children's later creative achievement.     

Including others in the self

We propose that to some extent, people treat the resources, perspectives, and identities of close others as their own. This proposal is supported by allocation, attribution, response time, and memory experiments. Recently, we have applied this idea to deepening understanding of feeling “too close” (including too much of the other in the self leading to feeling controlled or a loss of identity), the effects of relationship loss (it is distressing to the extent that the former partner was included in the self, liberating to the extent that the former partner was preventing self-expansion), ingroup identification (including ingroup in the self), and the effect of outgroup friendships on outgroup attitudes (including outgroup member in the self entails including outgroup member's identity in the self).     

The Relationship Between the Constructs of Religiousness and Prejudice: A Structural Equation Model Analysis

Research examining the connection between religiousness and prejudice has used scales exclusively as proxies for the underlying constructs. Scholars in the psychology of religion, however, are ultimately concerned about the nature of religious constructs and their relationships with other variables, and the use of scales provides only indirect information concerning these constructs. To overcome this limitation, structural equation modeling (SEM) allows researchers to gather information about the relationship among constructs directly. The present study used SEM to examine the relationship between religion and prejudice using four of the most important and heavily researched constructs in the psychology of religion: religious commitment, orthodoxy, fundamentalism, and openness, as well as their relationships with three types of prejudice: racial, sexual orientation, and religious. The strongest results revealed that religious commitment, orthodoxy, and fundamentalism were linked positively with sexual orientation prejudice, whereas religious openness was linked negatively with that type of prejudice. Other religiousness–prejudice relationships were weaker and also more complex.     

Recidivism and dependency in a psychiatric population: An investigation with kelly's dependency grid

Over the years there have been varied attempts to explain or predict recidivism, which is a phenomenon whereby psychiatric patients are hospitalized repeatedly. Recent efforts to predict relapse have used specific symptoms (Harris, Bergman, & Bachrach, 1986), diagnoses (Kastrup, 1987; Lally, 1989), postdischarge treatment compliance (Caton, Koh, Fleiss, Barrow, & Goldstein, 1985), and the level of emotional expression in the family environment (Doane, Goldstein, Miklowitz, & Falloon, 1986) as relapse predictors. Despite progress, many unanswered questions remain. The present study examined recidivism from the perspective of personal construct psychology (Kelly, 1955). The Dependency Grid was administered to 33 first-admission patients, 39 recidivists, and 26 controls. As hypothesized, recidivists identified the smallest social network and the fewest people on whom they believed they actually could rely in a crisis. In contrast, patients experiencing their first admission offered an extensive array of individuals to whom they felt they could turn in a crisis. Controls reported the greatest number of social resources potentially available to them, but then selectively chose a sample of them as individuals on whom they would be comfortable relying. Results are discussed in terms of support for Kelly's personal construct theory.