Active and passive avoidance following the administration of systemic DSP4, xylamine, or p-chloroamphetamine

Groups of rats were administered either DSP4 (50 mg/kg, ip), xylamine (50 mg/kg, ip), or p-chloroamphetamine (2 X 10 mg/kg, ip), either 2 weeks or 1 week before the testing of two-way active avoidance. DSP4 and xylamine, the selective noradrenaline (NA) neurotoxins, caused a two-way avoidance impairment but p-chloroamphetamine, the selective 5-hydroxytryptamine (5-HT) neurotoxin, did not do so. Pretreatment with desipramine (20 mg/kg, ip) blocked the avoidance impairment caused by DSP4 and xylamine treatment. Neither DSP4 nor xylamine caused any alteration of passive avoidance retention. The biochemical analyses indicated severe NA, but not 5-HT, depletions in the DSP4 and xylamine conditions and drastic 5-HT, but not NA, depletions in the p-chloroamphetamine conditions. These results confirm and extend earlier findings concerning the role of NA in avoidance behavior.     

Fetal brain tissue transplants reduce visual deficits in adult rats with bilateral lesions of the occipital cortex

Fetal brain tissue from the occipital or the frontal cortex was implanted into the damaged occipital cortex of adult rats. The animals receiving grafts of embryonic frontal cortex showed partial restoration of brightness discrimination while recipients given homologous implants of occipital cortex were as impaired as those animals with lesions alone. Neither frontal nor occipital grafts aided in the performance of a pattern discrimination problem; both groups of brain-damaged animals were unable to learn the task. Nonetheless, both groups of animals had viable and enlarged grafts with similar neuronal and glial profiles.     

The kinematics,movement phasing and timing of a skilled action in response to varying conditions of uncertainty

This study was designed to provide a detailed analysis of the parameters which interact to produce a field hockey drive. The drive was performed by an elite performer under two conditions of uncertainty (Blocked and Random). The subject was asked to drive a field hockey ball toward a specified target. In the Blocked condition the speed of the approaching ball remained constant (20, 30 and 40 m.p.h.) while in the Random condition these speeds were randomly assigned to each trial. Cine analysis of the subject's successful responses under the two experimental conditions led to an investigation of the kinematics, phasing, and timing of the stroke. The subject placed emphasis upon varying the initial phases of the stroke (i.e., backswing and preparatory phases) in order to produce a temporally consistent ballistic downswing to ball contact. It seemed likely that the subject appraised the ball speed that was being delivered and then incorporated additional stick movement to ‘mark time’ before initiating temporally consistent movement phases, as spatial uncertainty increased, the subject delayed her response initiation, but then tended to respond in intervals of one reaction time for each stroke phase. Consistency was evident for displacement and initiation point values, but to a lesser extent than existed for the other variables. However, as a result of this adjustment in spatial location and displacement of the stick end during the preliminary phases of the response, the subject was able to produce a consistent and accurate ballistic downswing.     

Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks

Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory.     

Women's marital-familial statuses and work histories: Some conceptual considerations

Although vocational psychologists and sociologists have a long history of researching occupational choice, their theoretical postures have almost always been shaped in light of information on males, with little consideration for females. This article is an addition to others which attempt to correct this shortcoming in the literature. The article reviews the dominant conceptual schemes used to study occupational choice, considers potentially female-specific variables, and provides a typology for the analysis of women's marital-familial statuses and work modes.     

The effects of graphemic,phonetic, and semantic relationships on access to lexical structures

The question of whether or not lexical information is accessed directly from a visual code or by a process of phonetic mediation was investigated in three lexical decision experiments. Phonetic similarity influenced decisions about visually presented words only when they were to be discriminated from orthographically regular nonwords. When consonant strings or random letter strings were used as nonwords, phonetic similarity effects were absent, and graphemic similarity exerted a powerful effect while evidence of semantic priming was found. This pattern was interpreted as evidence of direct lexical access, which is probably the normal processing mode for skilled readers. Phonetic coding, when it occurs, may be a storage strategy rather than a part of the addressing chain for lexical structures.     

Meaning,amount of processing,and memory for words

Two experiments were carried out in order to try to resolve the controversy about whether the semantic processing of a word necessarily involves all the elements of its meaning. In the first experiment, subjects categorized a list of auditorially presented words according to whether or not they were natural consumable solids (e.g., “apple“). They were then given an unexpected test of their ability to recall the whole list, which contained equal numbers of words with none, one, two, or all three of the target components. The results confirmed the prediction that the greater the number of components a word has in common with a target category, the better it will be recalled. The second experiment used a visual presentation of a list of words, which subjects scanned for members of a particular target category. There were four different target categories assigned to independent groups of subjects. The results again confirmed the prediction. On the assumption that memorability in such tasks is determined by amount of processing, we conclude that some elements of the meaning of a word can be processed without having to process all of them.