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961.
Benetti F da Silveira CK da Silva WC Cammarota M Izquierdo I 《Neurobiology of learning and memory》2012,97(1):54-58
Early partial maternal deprivation causes long-lasting neurochemical, behavioral and brain structural effects. In rats, it causes a deficit in memory consolidation visible in adult life. Some of these deficits can be reversed by donepezil and galantamine, which suggests that they may result from an impairment of brain cholinergic transmission. One such deficit, representative of all others, is an impairment of memory consolidation, clearly observable in a one-trial inhibitory avoidance task. Recent data suggest a role of brain histaminergic systems in the regulation of behavior, particularly inhibitory avoidance learning. Here we investigate whether histamine itself, its analog SKF-91844, or various receptor-selective histamine agonists and antagonists given into the CA1 region of the hippocampus immediately post-training can affect retention of one-trial inhibitory avoidance in rats submitted to early postnatal maternal deprivation. We found that histamine, SKF-91844 and the H2 receptor agonist, dimaprit enhance consolidation on their own and reverse the consolidation deficit induced by maternal deprivation. The enhancing effect of histamine was blocked by the H2 receptor antagonist, ranitidine, but not by the H1 receptor antagonist pyrilamine or by the H3 antagonist thioperamide given into CA1 at doses known to have other behavioral actions, without altering locomotor and exploratory activity or the anxiety state of the animals. The present results suggest that the memory deficit induced by early postnatal maternal deprivation in rats may in part be due to an impairment of histamine mediated mechanisms in the CA1 region of the rat hippocampus. 相似文献
962.
de Oliveira IR Hemmany C Powell VB Bonfim TD Duran EP Novais N Velasquez M Di Sarno E Alves GL Cesnik JA 《CNS spectrums》2012,17(1):16-23
IntroductionThe best prevention against relapse results when patients are taught to restructure negative core beliefs (CBs). Efficacy of the trial-based thought record (TBTR) in decreasing the credit given by patients to negative CBs and corresponding emotions was evaluated.MethodPatients (n = 166) were submitted to a simulation of a legal trial to assess their adherence to negative CBs and corresponding emotions after each cognitive therapy technique incorporated by TBTR. RESULTS: Significant reductions existed in percent values after the first and second defense attorney pleas, as well as after jury's verdict and initial preparation for the appeal (p < 0.001), relative to the investigation phase. Significant differences also emerged between the defense attorney's first and second pleas and between the defense attorney's second plea and jury's verdict, as well as preparation for the appeal (p < 0.001). There was no significant difference between percentages presented by patients submitted to TBTR used in the empty chair format relative to the conventional format. Similarly, there was no difference between outcomes, regardless of therapists' level of exposure to TBTR.ConclusionTBTR may help patients reduce attachment to negative CBs and corresponding emotions. Outcomes were significantly favorable regardless of the format use and therapists' level of exposure to TBTR. 相似文献
963.
Osilla KC D'Amico EJ Díaz-Fuentes CM Lara M Watkins KE 《Cultural diversity & ethnic minority psychology》2012,18(2):192-202
Culturally and linguistically appropriate interventions are needed to reduce the risk of driving under the influence (DUI) recidivism among diverse populations. Using core elements of Motivational Interviewing, we developed a culturally relevant web-MI intervention (web-MI) in English and Spanish to serve as a standalone or adjunctive program in DUI educational settings and evaluated its feasibility and acceptability among clients with first-time DUI offenses. We conducted an iterative formative assessment using focus groups with staff (n = 8) and clients (n = 27), and usability interviews with clients (n = 21). Adapting MI for the web was widely accepted by staff and clients. Clients stated the web-MI was engaging, interactive and personal, and felt more comfortable than past classes and programs. Spanish-speaking clients felt less shame, embarrassment, and discomfort with the web-MI compared to other in-person groups. Results support the viability of web-MI for DUI clients at risk for recidivism and highlight the importance of adapting the intervention for diverse populations. Key decisions used to develop the web-MI are discussed. 相似文献
964.
Since modernity, the concept of subject supposes both an anthropocentric and a dualistic view of life and reality. In this study, we carry out an analytic interpretation of the Descartes’ notion of subject, in order to build a different dimension of the concept of subject. We discuss the activity of computing, as the manner by which the living subject relates with and in-forms the world. We further examine computing in the aging yeast as an example of living subject and we try to comprehend the maturity of the subjectivity in Descartes’ res cogitans and in our proposed res computans. 相似文献
965.
An experiment was conducted using a human instrumental learning task with the goal of evaluating the mechanisms underlying the deleterious effect of context-switching on responding to an unambiguous stimulus when contexts are informative to solve the task. Participants were trained in a context-based reversal discrimination in which two discriminative stimuli (X and Y) interchange their meaning across contexts A and B. In context A, discriminative stimulus Z consistently announced that the relationship between a specific instrumental response (RI) and a specific outcome (O1) was in effect. Performance in the presence of stimulus Z was equally deteriorated when the test was conducted outside the training context, regardless of whether the test context was familiar (context B) or new (context C). This result is consistent with the idea that participants code all the information presented in an informative context as context-specific with the context playing a role akin to an occasion setter. 相似文献
966.
This review systematically investigates rates of physical intimate partner violence for both sexes in international samples. Surveys that accessed nationally representative samples, used gender inclusive methodology and neutral contexts are reviewed to determine 12-month and lifetime victimization and perpetration rates. Discrepancies between international rates, and the impact that gender equality may have upon these differences is also investigated. Electronic databases were systematically searched to identify surveys that met inclusion criteria. Eleven surveys were reviewed. Of these, Family Violence surveys had the highest methodological quality and showed equal rates for both sexes. Surveys of lesser quality typically showed higher female victimization and male perpetration rates. Countries at the extremes of gender empowerment measure scores differed in their patterns of rates. Gender equality in the US was associated with symmetry for the sexes, and inequality in Uganda associated with higher female victimization. However, as countries tended to use different methods to investigate the problem it was not possible to compare the effects of gender equality on differences in international rates of IPV. It is concluded that survey methodology needs to be consistent across nations, and specifically target family violence if true rates are to be determined and compared across the globe. 相似文献
967.
Penelope P. Espinoza Stephanie A. Quezada Rodolfo Rincones E. Natalia Strobach María Armida Estrada Gutiérrez 《Social Psychology of Education》2012,15(4):533-554
The present work investigates the validation of a newly developed instrument, the attributional bias instrument, based on achievement attribution theories that distinguish between effort and ability explanations of behavior. The instrument further incorporates the distinction between explanations for success versus failure in academic performance. An important characteristic of the instrument is that it can be used to assess biased attributions. For instance, attributional gender bias is the tendency to generate different attributions (explanations) for female versus male students’ performance in math. Whereas boys’ successes in math are attributed to ability, girls’ successes are attributed to effort; conversely, boys’ failures in math are attributed to a lack of effort and girls’ failures to a lack of ability. Previous research has shown this bias to be committed by teachers, parents, and students themselves. In the present study, high school students in Mexico were administered the instrument and asked to generate attributions for their successes and failures in math. Findings revealed: (1) a factor analysis confirmed the proposed structure of the instrument, (2) boys and girls committed the attributional gender bias, replicating effects in U.S. samples, and (3) additional analyses involving related measures further supported valid use of the instrument. 相似文献
968.
Martín Plot 《Continental Philosophy Review》2012,45(2):235-259
Although Merleau-Ponty??s early phenomenology of perception and his essays on art, politics, and language already showed an affinity between the aesthetic phenomena of expression and style and the political and cultural dynamics of society at large, this paper specifically focuses on his late theorizing of the notion of flesh and its relevance to his late understanding of politics and democracy. The emergence of flesh as a concept was contemporary to Merleau-Ponty??s break with Marxism as a philosophical model and with revolutionary dialectics as a political project. It is by showing that such a break was consistently grounded on his theorizing of the being flesh of both the body and of society that this paper shows Merleau-Ponty??s unique contribution to democratic theory and to contemporary political philosophy. In the course of this analysis, it will become clear that in philosophically breaking with the position of a ??no that is a yes????i.e. the model of the revolution, which implies a total negation of the given that becomes a total affirmation of the new order (dictatorship) once in power??he would politically embrace the Weberian ??heroic liberalism????or his ??non-communist left????of parliamentary democracy. 相似文献
969.
Algarabel S Fuentes M Escudero J Pitarque A Peset V Mazón JF Meléndez JC 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2012,19(5):608-619
ABSTRACT There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (MCI). Whereas lower performance in recollection is the hallmark of MCI, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed light on the pattern of responding in recollection and familiarity in MCI. Five groups of participants were tested. The main participant samples were those formed by two MCI groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups. Whereas one of the control groups served to assess the performance of the MCI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in MCI. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MCI stage. 相似文献
970.
Cunillera T Fuentemilla L Periañez J Marco-Pallarès J Krämer UM Càmara E Münte TF Rodríguez-Fornells A 《Cognitive, affective & behavioral neuroscience》2012,12(1):16-33
In this study, we sought to dissociate event-related potentials (ERPs) and the oscillatory activity associated with signals
indicating feedback about performance (outcome-based behavioral adjustment) and the signals indicating the need to change
or maintain a task set (rule-based behavioral adjustment). With this purpose in mind, we noninvasively recorded electroencephalographic
signals, using a modified version of the Wisconsin card sorting task, in which feedback processing and task switching could
be studied separately. A similar late positive component was observed for the switch and correct feedback signals on the first
trials of a series, but feedback-related negativity was observed only for incorrect feedback. Moreover, whereas theta power
showed a significant increase after a switch cue and after the first positive feedback of a new series, a selective frontal
beta–gamma increase was observed exclusively in the first positive feedback (i.e., after the selection of the new rule). Importantly,
for the switch cue, beta–alpha activity was suppressed rather than increased. This clear dissociation between the cue and
feedback stimuli in task switching emphasizes the need to accurately study brain oscillatory activity to disentangle the role
of different cognitive control processes. 相似文献