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971.
Evidence suggests that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP dependent protein kinase (PKG) signaling pathway plays a key role in memory processing, but the actual participation of this signaling cascade in the hippocampal CA1 during morphine-induced reward memory remains unknown. In this study, we investigated the role of the NO/sGC/PKG signaling pathway in the CA1 on morphine-induced reward memory using a conditioned place preference (CPP) paradigm. We found that rats receiving an intraperitoneal (i.p.) injection of 4mg/kg morphine exhibited CPP, whereas rats treated with only 0.2mg/kg morphine failed to produce CPP. Intra-CA1 injection of the neuronal NO synthase (nNOS) inhibitor 7-NI, the sGC inhibitor ODQ or the PKG inhibitor Rp-8-Br-PET-cGMPS had no effect on the acquisition of CPP by 4mg/kg morphine. Intra-CA1 injection of 7-NI blocked the consolidation of CPP induced by 4mg/kg morphine, and this amnesic effect of 7-NI was mimicked by ODQ and Rp-8-Br-PET-cGMPS. Intra-CA1 injection of the NOS substrate L-arg or the sGC activator YC-1 with an ineffective dose of morphine (0.2mg/kg, i.p.) elicited CPP. This response induced by L-arg or YC-1 was reversed by pre-microinjection of Rp-8-Br-PET-cGMPS in the CA1. These results indicated that the activation of the NO/sGC/PKG signaling pathway in the CA1 is necessary for the consolidation of morphine-related reward memory. 相似文献
972.
Ya‐Ling Wang Yi‐Cheng Lin Chin‐Lan Huang Kuang‐Hui Yeh 《Asian Journal of Social Psychology》2012,15(3):198-207
Psychological distance in terms of its purpose as a psychological adjustment is currently not well understood. Some researchers claim that psychological distance serves as an emotion regulator, while others argue that psychological distance has the reverse effect, leading to cognitive avoidance and rumination. To elucidate upon this discrepancy, we propose that a complementary matching of psychological distance to one's habitual psychological distance perspective may lead to better emotion regulation when compared to the original perspective (i.e. fixing on either psychological immersion or distance). This study hypothesizes that a complementary matching of psychological distance to one's habitual perspective generally leads to better emotion regulation; specifically, individuals with high avoidant attachment, who habitually distance themselves from their experiences, may benefit from psychological immersion, while individuals with high anxious attachment, who habitually immerse themselves in their experiences, may benefit from psychological distancing. A total of 83 participants completed measures of adult attachment orientations; read a conflict scenario, triggering their attachment systems; and then rewrote that scenario using designated pronouns, thereby employing psychological immersion or psychological distance. Participants in the self‐immersed condition were asked to write from the first‐person perspective, whereas those in the self‐distancing condition were asked to write from the third‐person perspective. The results support our hypothesis of a complementary matching of psychological distance and habitual perspective. 相似文献
973.
Payne BR Gao X Noh SR Anderson CJ Stine-Morrow EA 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2012,19(1-2):122-149
The present study was an examination of how exposure to print affects sentence processing and memory in older readers. A sample of older adults (N = 139; Mean age = 72) completed a battery of cognitive and linguistic tests and read a series of sentences for recall. Word-by-word reading times were recorded and generalized linear mixed effects models were used to estimate components representing attentional allocation to word-level and textbase-level processes. Older adults with higher levels of print exposure showed greater efficiency in word-level processing and in the immediate instantiation of new concepts, but allocated more time to semantic integration at clause boundaries. While lower levels of working memory were associated with smaller wrap-up effects, individuals with higher levels of print exposure showed a reduced effect of working memory on sentence wrap-up. Importantly, print exposure was not only positively associated with sentence memory, but was also found to buffer the effects of working memory on sentence recall. These findings suggest that the increased efficiency of component reading processes that come with life-long habits of literacy buffer the effects of working memory decline on comprehension and contribute to maintaining skilled reading among older adults. 相似文献
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975.
延迟学习判断是学习判断的一种形式,是指在材料学习完以后间隔一段时间才发生的学习判断。在与即时学习判断的对比研究中发现,延迟学习判断具有较高的相对准确性,这种现象被称为延迟学习判断效应。研究者进行了大量的研究并提出了多种理论来解释这种延迟学习判断效应。随着研究的不断深入,延迟学习判断的研究从研究指标、研究方法甚至是研究的理论基础都在不断更新。延迟学习判断的研究进展,包括主要理论和相关实验,以及最新研究成果将被介绍。最后,文章梳理了延迟JOL的研究进程,并指出了未来的研究方向。 相似文献
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作者通过实验考察了大学生被试对五种充分条件句语义关系知觉对其条件推理的影响。两个实验的结果表明,被试对条件句中前后件之间语义关系的知觉理解影响和调节其相应的条件推理的成绩。实验1新发现,被试对充分条件句后件对前件必要性的知觉理解存在难易差异,对许可句和定义句的后件必要性容易知觉,对偶然句、义务句和因果句的后件必要性难以知觉。实验2新发现,被试对充分条件句后件对前件必要性的知觉理解的难易差异导致被试在否定后件式推理成绩上的差异,对许可句和定义句的否定后件式推理成绩显著高于对偶然句、义务句和因果句的否定后件式推理成绩,对充分条件句否定后件式推理成绩随对后件必要性知觉增加而增加。 相似文献
979.
在许多社会科学研究中,社会称许性会对研究的效度产生不良影响。研究者希望能得到被试的真实态度和反应,从而极力避免这种社会称许性偏见。内隐测量工具的一个主要目的是让研究者能够获得未加任何粉饰的态度测量结果从而消除和避免自我表现和社会称许性。本文通过四个实验考察了内隐联想测验的可掩饰性、掩饰的持久性、掩饰的条件化和IAT经验的迁移性,结果显示:(1)被试可以通过一定的反应策略来掩饰其真实的内隐态度,从而使所测得的个体内隐态度和群体内隐态度失真,典型的反应策略是均衡相容和不相容任务的反应速度;(2)内隐联想测验的可掩饰性需以先前的IAT经验为基础,且IAT经验无需属于相同的测验范畴,对IAT原理的掌握将有助于被试成功地实施掩饰;(3)内隐联想测验的可掩饰性具有一定的时效性,先前的IAT经验越久远,则成功掩饰的可能性越低;总之,内隐联想测验并不能彻底避免社会称许性。 相似文献
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