Making the case for objective performance metrics in newborn screening by tandem mass spectrometry

The expansion of newborn screening programs to include multiplex testing by tandem mass spectrometry requires understanding and close monitoring of performance metrics. This is not done consistently because of lack of defined targets, and interlaboratory comparison is almost nonexistent. Between July 2004 and April 2006 (N=176,185 cases), the overall performance metrics of the Minnesota program, limited to MS/MS testing, were as follows: detection rate 1:1,816, positive predictive value 37% (54% in 2006 till date), and false positive rate 0.09%. The repeat rate and the proportion of cases with abnormal findings actually been reported are new metrics proposed here as an objective mean to express the overall noise in a program, where noise is defined as the total number of abnormal results obtained using a given set of cut-off values. On the basis of our experience, we propose the following targets as evidence of adequate analytical and postanalytical performance: detection rate 1:3,000 or higher, positive predictive value>20%, and false positive rate<0.3%.     

Does a regional accent perturb speech processing?

The processing costs involved in regional accent normalization were evaluated by measuring differences in lexical decision latencies for targets placed at the end of sentences with different French regional accents. Over a series of 6 experiments, the authors examined the time course of comprehension disruption by manipulating the duration and presentation conditions of accented speech. Taken together, the findings of these experiments indicate that regional accent normalization involves a short-term adjustment mechanism that develops as a certain amount of accented signal is available, resulting in a temporary perturbation in speech processing.     

Social processes affecting the mnemonic consequences of rumors on children’s memory

This research examined whether the impact of overheard rumors on children’s memory for their experiences varies as a function of social processes. The results of two experiments revealed that the very same errant rumor had different consequences for children’s recollections depending on the degree and type of social interactions they had with peers after exposure to the rumor. In both experiments, 3- to 5-year-olds overheard a false rumor about a recently experienced event and then were interviewed about the event 1 week later. In Experiment 1, children were more likely to report experiencing rumored-but-nonoccurring information if they were allowed to interact naturally with peers following exposure to the rumor than if they were prevented from peer exchange. In Experiment 2, exposure to the rumor induced greater memory contamination if it was planted among familiar peers than if it was encountered among strangers.     

Increased Error-Related Brain Activity in Six-Year-Old Children with Clinical Anxiety

Anxiety disorders are the most frequently diagnosed form of psychopathology in children and often result in chronic impairment that persists into adulthood. Identifying neurobehavioral correlates of anxiety that appear relatively early in life would inform etiological models of development and allow intervention and prevention strategies to be implemented more effectively. The error-related negativity (ERN), a negative deflection in the event-related potential at fronto-central sites approximately 50 ms following the commission of errors, has been consistently found to be larger among anxious adults. The current study sought to extend these findings to even younger individuals: the ERN was elicited by a Go/NoGo task in 48 six year-old children with a clinical anxiety disorder assessed by diagnostic interview and 48 age-matched controls. In addition to child anxiety disorder, the ERN was examined in relation to maternal history of anxiety disorder, which was previously related to a smaller ERN. Anxious children were characterized by a larger (i.e., more negative) ERN and maternal history of anxiety disorder was associated with a smaller ERN. Thus, the relationship between an increased ERN and clinical anxiety is evident by age 6, and this effect appears independent from an opposing influence of maternal anxiety history on the ERN. These findings support the ERN as a promising neurobehavioral marker of anxiety, and implications are discussed.     

The role of career values for work engagement during the transition to working life

The present longitudinal study examined the role of career values for work engagement across the transition from university education to working life. Finnish young adults reported on their career values (intrinsic, rewards, and security values) at the age of 23; and the degree of person–organization fit (value congruence, and congruence between one's education and the job), subjective income and economic stress two years later at the age of 25. Work engagement was assessed at both measurement points. Structural equation modeling results showed, first, that intrinsic but not rewards or security career values were related to work engagement. Second, value congruence and having a job which was related to young adults' educational field were positively associated with work engagement. Our findings suggest that along with person–organization fit, intrinsic career values are a significant factor in shaping and facilitating successful transitions from education to work.     

Cognitive development of lead exposed children from ages 6 to 15 years: an application of growth curve analysis.

The effect of lead exposure on cognitive growth patterns was assessed in a longitudinal study of 196 children. Performances on tests of verbal comprehension and perceptual organization (Vocabulary & Block Design, Wechsler Intelligence Scales for Children) were measured at ages 6.5, 11 and 15 years. Growth curve analyses revealed that the quadratic model best described the relationship between test scores and age. Children with higher lead levels, as measured at age 15 years, demonstrated lower verbal comprehension scores over time and greater decline in their rate of Vocabulary development at age 15 years, as compared to children with lower lead levels. Lead exposure was not significantly associated with growth in perceptual organization test scores. Socioeconomic status and maternal intelligence were statistically significantly associated with growth patterns for both test scores, independent of the effects of lead. The findings suggest that lead negatively impacts the developmental progression of specific cognitive skills from childhood through adolescence.     

Phlegmatic temperament from the psychiatric angle

Unlike the other five deadly sins of the Church, sloth is not attributed to an instinct or an impulse but to an anancastic form of reaction. A phlegmatic person is characterised by a lack of egoistic or altruistic instincts while feelings of nausea or fear are increased. Among phlegmatic persons those of clinical importance are epileptoid psychopaths, oblomovists and those exhibiting (forms of) phlegmatic temperament combined with obsessional or hysterical neurosis.     

Depth of Field: Using photographs and narratives to explore and reflect on ageing

The learning landscape of the higher education environment is changing, with an increased focus over the past decade on how educators might begin to cultivate reflective skills in health professions students. In addition, changing professional requirements demand that health professionals are adequately prepared to practise in today’s complex healthcare systems, including responding to changing demographics of population ageing. In this educational case study, we will share how we (a group of education, medical and nursing academics) developed ‘Depth of Field: Exploring Ageing’ a digital, consumer-driven, interprofessional reflective learning resource that uses photographs, narrative and small-group work to strengthen reflective capacity in current and/or future health professionals.