Anatomy of the episodic buffer: a voxel-based morphometry study in patients with dementia

In 2000 Baddeley proposed the existence of a new component of working memory, the episodic buffer, which should contribute to the on-line maintenance of integrated memory traces. The author assumed that this component should be critical for immediate recall of a short story that exceeds the capacity of the phonological store. Accordingly, patients with Alzheimer's dementia (AD) should suffer of a deficit of the episodic buffer when immediate recall of a short story is impossible. On the other hand, the episodic buffer should be somewhat preserved in such patients when some IR can occur (Baddeley and Wilson, 2002). We adopted this logic for a voxel-based morphometry study. We compared the distribution of grey-matter density of two such groups of AD patients with and of a group of age-matched controls. We found that both AD groups had a significant atrophy of the left mid-hippocampus; on the other hand, the anterior part of the hippocampus was significantly more atrophic in patients who were also impaired on the immediate prose recall task. Six out of ten patients with no immediate recall were spared at "central executive" tasks. Taken together our findings suggest that the left anterior hippocampus contributes to the episodic buffer of the revised working memory model. We also suggest that the episodic buffer is somewhat independent from the central executive component of working memory.     

Investigating linguistic relativity through bilingualism: the case of grammatical gender

The authors investigated linguistic relativity effects by examining the semantic effects of grammatical gender (present in Italian but absent in English) in fluent bilingual speakers as compared with monolingual speakers. In an error-induction experiment, they used responses by monolingual speakers to establish a baseline for bilingual speakers and show that gender affects the semantic substitution errors made by monolingual Italian speakers compared with monolingual English speakers. They then showed that Italian-English bilingual speakers behave like monolingual English speakers when the task is in English and like monolingual Italian speakers when the task is in Italian, hence exhibiting appropriate semantic representations for each language. These results show that for bilingual speakers there is intraspeaker relativity in semantic representations and, therefore, that gender does not have a conceptual, nonlinguistic effect. The results also have implications for models of bilingual semantic memory and processing.     

A Type Hierarchy of Selection Processes for the Evaluation of Evolutionary Analogies

In this paper I propose a type-hierarchy approach to provide an intersubjective framework for the evaluation of evolutionary analogies. This approach develops David Hull’s and others’ attempts to provide full generalisation for selection processes, in order to show that sociocultural development and, particularly, scientific change can be considered as an instance of Darwinian selection. I argue that the recent work by Eileen Cornell Way on type hierarchies can offer the kind of generalisation needed to solve the main problems that still affect Hull’s theory and to show that the evolutionary analogy is, after all, only a particular way of grouping phenomena together. If Hull’s main objective is a unified theory of selection, which supports the idea that science selection and natural selection obey the same laws, I also argue that the type hierarchy approach to models shows that this objective is unsustainable as it stands, and is in need of further development. I will firstly introduce the general outline of the type hierarchy approach to models. Then, after a brief recapitulation of Hull’s main points and difficulties, I will try and construct a hierarchy for a general abstraction of selection processes. Finally I will introduce the main criticisms that Hull’s work has faced from philosophers and scientists, and show how they compare with my proposal.     

Self-Perception and Deceptive Behavior: The Uniqueness of Feminine Males

The present study investigated the relationshipbetween deception and selfperception of traditionallymasculine and feminine characteristics. In the firststage of the study, 730 fifth and sixth graders (377 boys and 353 girls), all Jewish Israelis,completed an adapted form of the BSRI (Bem, 1974). Inthe second stage of the study, 154 boys were given threetypes of questionnaires, one consisting of questions dealing with traditionally masculine topics,the second with traditionally feminine topics, and thethird with neutral topics. Since most of the questionswere very difficult, participants faced failure, but were given an opportunity to deceive andpretend to know more than they really did. It was found,as predicted, that cross-sex males, i.e., those whoself-endorse a large amount of traditionally feminine characteristics and a small amount oftraditionally masculine characteristics, were a uniquegroup. They were the only group who deceived more on thegender-inconsistent than gender-consistent task. The other gender role groups deceived more on thegender-consistent task than on the gender-inconsistenttask, or equally on both tasks. The results arediscussed within the context of the debate over themeaning of self-endorsement of masculine and femininetraits.     

Grammatical gender effects on cognition: implications for language learning and language use

In 4 experiments, the authors addressed the mechanisms by which grammatical gender (in Italian and German) may come to affect meaning. In Experiments 1 (similarity judgments) and 2 (semantic substitution errors), the authors found Italian gender effects for animals but not for artifacts; Experiment 3 revealed no comparable effects in German. These results suggest that gender effects arise as a generalization from an established association between gender of nouns and sex of human referents, extending to nouns referring to sexuated entities. Across languages, such effects are found when the language allows for easy mapping between gender of nouns and sex of human referents (Italian) but not when the mapping is less transparent (German). A final experiment provided further constraints: These effects during processing arise at a lexical-semantic level rather than at a conceptual level.     

GOOD or BAD responder? Behavioural and neuroanatomical markers of clinical response to donepezil in dementia

We explored the neuropsychological and neuromorphometrical differences between probable Alzheimer's disease patients showing a good or a bad response to nine months treatment with donepezil. Before treatment, the neuropsychological profile of the two patient groups was perfectly matched. By the ninth month after treatment, the BAD-responders showed a decline of the MMSE score together with a progressive impairment of executive functions. A voxel-based morphometry investigation (VBM), at the time of the second neuropsychological assessment, showed that the BAD-responders had larger grey and white matter atrophies involving the substantia innominata of Meynert bilaterally, the ventral part of caudate nuclei and the left uncinate fasciculus, brain areas belonging to the cholinergic pathways. A more widespread degeneration of the central cholinergic pathways may explain the lack of donepezil efficacy in those patients not responding to a treatment that operates on the grounds that some degree of endogeneous release of acetylcholine is still available.     

Assessing Vindictiveness: Psychological Aspects by a Reliability and Validity Study of the Vengeance Scale in the Italian Context

Vengeance can be commonly defined as the disposition towards the infliction of harm in return for perceived injury or insult or as simply getting back at another person. This paper describes a contribution to the Italian validation of the Vengeance Scale (Stuckless and Goranson, Journal of social Behavior and Personality 7: 25?C42, 1992) following the same steps of the original authors and shows psychological implications of vindictive behavior. 377 under-graduate students responded to the Big Five Questionnaire, State Trait Anger Expression Inventory and a back-translated Italian version of the Vengeance Scale (IVS). The IVS shows good psychometric properties. Convergent validity is shown by correlations with crucially connected variables (anger, empathy, social desirability). Factorial analysis suggested that the IVS is basically a one-dimensional measure. Regression analysis reveals that empathy, anger and emotional stability are significant predictors of vengeance. General results show that the IVS is a good instrument of evaluation of the tendency to be vindictive. Statistic analysis highlights that specific personality traits are involved in vindictive behavior; furthermore the interactions between some features of subject and the environment appear determinant. The implications and utility of the IVS in future research are discussed.     

Anxiety and Depression in Patients with Amyotrophic Lateral Sclerosis and Their Caregivers

A large number of studies have investigated a variety of psychological aspects in people with Amyotrophic Lateral Sclerosis, but there is still considerable uncertainty concerning the actual morbidity, in particular for anxiety. We aim to evaluate depression levels and anxiety disposition in ALS patients and their caregivers, in comparison to healthy controls. We conducted a cross-sectional comparison between people with ALS, their caregivers and a non-clinical control group in order to evaluate anxiety and depression levels. 40 ALS patients, their caregivers and 40 healthy adult subjects completed the Beck Depression Inventory II (BDI-II) and the State-Trait Anxiety Inventory—Y2 scale (STAI). We compared overall and single item scores in order to find differences between the three groups. BDI-II scores were significantly different between groups. Depression scores were higher for patients than for healthy controls, in both somatic and psychological sub-scales. Caregivers presented higher levels of psychological depression in comparison with healthy controls, and lower scores of somatic depression in comparison to patients. No differences were found in trait anxiety levels comparing the three groups. ALS patients and their caregivers developed more depression related symptomatology than the non-clinical sample. However, susceptibility to anxiety for both patients and caregivers seemed to be at a normal level.     

People,State and Civic Responses to Immigration,Xenophobia and Racism in the New South Africa

As a result of its political transformation, South Africa has become a victim of its own success, in that the shift in political power brought about a range of new discriminatory practices and victims. South Africa became a magnet for nationals from African countries who came to ‘the rainbow nation’ to share in the fruits of more stable governance and enjoy the benefits of a larger more dynamic economy, instead find themselves faced with xenophobia and racism. The aim of this paper is to analyse the development of immigration policy in post-apartheid South Africa in terms of the vulnerabilities and protections it has afforded migrants, as well as ways in which it has informed the behaviour of state officials from 1994 to 2008. It highlights trends and tensions surrounding immigration reform in the new South Africa and argues that legislation has made significant strides in informing the behaviour of high- and low-ranking officials in government and state departments but still has a long way to go.     

Eighteen-month-old human infants show intensive development in comprehension of different types of pointing gestures

This study explored children’s development in comprehending four types of pointing gestures with different familiarity. Our aim was to highlight human infants’ pointing comprehension abilities under the same conditions used for various animal species. Sixteen children were tested longitudinally in a two-choice task from 1 year of age. At the age of 12 and 14 months, infants did not exceed chance level with either of the gestures used. Infants were successful with distal pointing and long cross-pointing at the age of 16 months. By the age of 18 months, infants showed a high success rate with the less familiar gestures (forward cross-pointing and far pointing) as well. Their skills at this older age show close similarity with those demonstrated previously by dogs when using exactly the same testing procedures. Our longitudinal studies also revealed that in a few infants, the ability to comprehend pointing gestures is already apparent before 16 months of age. In general, we found large individual variation. This has been described for a variety of cognitive skills in human development and seems to be typical for pointing comprehension as well.