Clinical and Counseling Experiences of Early Adopters of Whole Exome Sequencing

Currently, there are limited data regarding the practice of genetic counseling for whole exome sequencing (WES). Improved understanding of how genetic counselors and other providers are educating, counseling, and communicating results may identify practice trends, and patient or provider needs. Between April 2013 and December 2014, we surveyed providers who ordered WES testing from GeneDx, a CLIA-certified laboratory. Forty-nine respondents completed the survey; 41 % of participants reported board certification in genetic counseling. Pre-test and post-test counseling was completed in all but one case each. Pre-test counseling lasted less than 1 h for 53 % of cases and 1 to 2 h for 43 %. Topics discussed with all patients included consent for testing, and incidental findings; other topics were variable. In contrast to pre-test counseling, 59 % reported post-test counseling lasting 1 to 2 h and 33 % less than an hour; post-testing counseling was significantly longer in cases with a definitive diagnosis than those without (p?=?0.0129). The survey findings indicate some variability regarding the amount of time spent on counseling and the topics discussed during pre-test counseling. Additional exploration, patient and provider educational resources, and potentially more specific guidelines regarding counseling for WES may be warranted.     

THE PSYCHOANALYTIC CONTRIBUTIONS OF MELITTA SCHMIDEBERG KLEIN. MORE THAN MELANIE KLEIN’S REBEL DAUGHTER

Compared to the impact of the work of Melanie Klein on the history of psychoanalysis, the contributions of her daughter, Melitta Schmideberg, passed almost unnoticed. At present, Schmideberg is solely remembered for having harshly attacked her mother at the start of the Controversial Discussions of the British Psycho-Analytical Society and for having coined the fitting expression “stable instability” in order to describe borderline and asocial personality disorders. However, the author discusses how the early groundbreaking discoveries of Klein with regards to primitive anxieties were the result of the joint work and thinking of Melanie and Melitta. Moreover, he argues that the conflict between the two, along with the subsequent polarization of their views, did not facilitate the development of psychoanalysis, neither did it help the analytic community to recognize the value of Melitta’s contributions to psychoanalysis.     

Psychometric Properties of the Italian Version of the Distress Tolerance Scale (DTS)

Journal of Psychopathology and Behavioral Assessment - Distress tolerance represents the capacity to bear and manage negative psychological states associated with distress. Low distress tolerance...     

Explaining unexplainable food choices

In recent years, psychologists have started to investigate the downstream consequences of nonconsciously activated behaviour (acting in an ‘explanatory vacuum’). Results have shown that when such behaviour is norm‐violating, people experience a need to confabulate reasons for this behaviour. The present paper aims to add more convincing evidence for this assumption. Study 1 addresses this question by replicating Study 2 of Adriaanse, Weijers, De Ridder, De Witt Huberts, and Evers ( 2014 ) while adding a condition in which people are post hoc provided with an explanation for their behaviour. Study 2 addresses this question by explicitly demanding an explanation for a nonconsciously steered choice. Both studies were conducted in the context of eating behaviour. Results of both studies were indicative of confabulation as a downstream consequence of nonconsciously steered eating behaviour (Study 1) or food choice (Study 2). Future research should address the potential of confabulated reasons spilling over to next occasions.     

Frustration Discomfort Scale (FDS). A Psychometric Study of the Italian Version

The Frustration Discomfort Scale (FDS, Harrington 2005a) was developed as a multidimensional measure of frustration intolerance. Frustration intolerance plays an important role in behavioral and cognitive model of emotional problems (Harrington 2006). The aim of this study is to translate the original English version of FDS into Italian and to assess the validity and reliability of the Italian version for application among Italian population. The Italian version of FDS-R, with the Hospital Anxiety and Depression Scale were administered on-line to 497 subjects aged from 18 to 66 years old. The exploratory factor analysis suggested a solution with four factors, plus a general factor. The factor analysis supports a multidimensional model of frustration intolerance but the distribution of the items is different. The internal consistency appears optimal for all four factors (range .637–.866). Despite encouraging evidence, the factor structure and other features of the FDS-R are yet to be firmly established.     

A Minimalist Theory of Appropriation

The Journal of Ethics - This paper offers a conditional defence of a minimalist theory of appropriation. The conclusion of its main argument is that, if people do enjoy a natural right to...     

Performance gains from directed training do not transfer to untrained tasks

Given the increasing complexity of the tasks and skills needed in modern society, developing effective training strategies is of tremendous practical importance. Furthermore, training that improves performance of both trained and untrained tasks would be highly efficient. In the present study, we examined how directed training contributes to skill acquisition, and more importantly, to engendering transfer of training to untrained tasks. Participants learned a complex video game for 30 h (Space Fortress, Donchin, Fabiani, & Sanders, 1989) using one of two training regimens: Hybrid Variable-Priority Training (HVT), with a focus on improving specific skills and managing task priority, or Full Emphasis Training (FET) in which participants simply practiced the game to obtain the highest overall score. We compared game performance, retention of training gains, and transfer of training to untrained tasks as a function of the training regimen. Compared to FET, HVT learners reached higher levels of mastery on the game and HVT was particularly beneficial for initially poor performing participants. This benefit persisted seven months after training. However, contrary to expectation, both HVT and FET were unsuccessful in producing transfer to untrained tasks compared to a group that received limited game experience, suggesting that directed training and practice can produce task-specific improvements, but improvements do not necessarily transfer from trained to untrained tasks.     

Mental contrasting instigates goal pursuit by linking obstacles of reality with instrumental behavior

The self-regulatory strategy of mental contrasting a desired future with obstacles of reality instigates goal-directed behavior when expectations of success are high and curbs goal-directed behavior when expectations are low (Oettingen, 2000). Two studies show that mental contrasting paired with high expectations of success creates strong associations between obstacles of reality and behavior instrumental to overcome these obstacles; mental contrasting paired with low expectations of success leads to weak associations. Reverse contrasting and irrelevant content control conditions did not produce expectancy-dependent associations between obstacle and instrumental behavior. Importantly, the strength of these associations mediated mental contrasting effects on goal-directed behavior (Study 2).     

Wishful information preference: positive fantasies mimic the effects of intentions

When pursuing set goals or intentions, people prefer to acquire information about the pros rather than the cons of their goal pursuit. Little is known about information preferences at earlier stages, when people are not yet serious about pursuing a given future. In the present three studies, positive fantasies that depicted an idealized desired future--compared with fantasies that questioned whether the future would be so ideal--created a preference for pros over cons, just like set goals or intentions have been shown to do. Positive fantasies created a stronger preference for pros versus cons when people were not serious about pursuing an imagined future or had just foregone an opportunity to do so. Results suggest that before people are engaged in serious pursuits, positive fantasies spur the selective acquisition of pro information, which may lead to poor decisions even if the acquired information is carefully deliberated on later.