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41.
Disturbances in exploratory behavior and functional recovery in the Y and radial mazes following dopamine depletion of the lateral septum 总被引:1,自引:0,他引:1
The effects of 6-hydroxydopamine (6-OHDA) injected into the lateral septum in rats were investigated for spontaneous alternation behavior in a Y maze and for spatially oriented behavior in an 8-arm radial maze. The performance of the animals in these tests was assessed under two physiological states, food-satiated and food-deprived. The selective depletion of septal dopaminergic concentrations leads to behavioral disturbances in both the Y and the radial mazes. These deficits disappeared when the animals with 6-OHDA lesions were food-deprived. These results confirm other studies from our laboratory and support two conclusions. First, lesions of dopaminergic neurons lead to behavioral impairments which resemble those found after the total lesion of the structure they innervate. Second, these behavioral impairments are responsive to therapeutic treatments, manipulations of the internal or external environment, or the level of arousal, since under certain conditions a recovery of function can occur in the absence of dopaminergic neurons. These two points provide additional support for a nonspecific role for the dopaminergic neurons originating in the ventral tegmental area. These neurons could have a permissive role in the functioning of the forebrain structures they innervate. 相似文献
42.
Substance P facilitation of memory: effects in an appetitively motivated learning task 总被引:1,自引:0,他引:1
K Schlesinger M A Pelleymounter J van de Kamp D L Bader J M Stewart T N Chase 《Behavioral and neural biology》1986,45(2):230-239
Food deprived, heterogeneous strain (HS/IBG) mice were trained on two different discrimination tasks for food reinforcement. In one experiment animals were trained to make spatial discriminations in a T maze. Immediately after training they were given subcutaneous injections of either substance P (1 ng/g) or vehicle. Twenty-four hours later the animals were given reversal training in the same maze. The results showed that substance P-treated animals took significantly longer to acquire the reversal habit than did control mice. In a second experiment, animals were trained to make visual discriminations in a T maze. Immediately after reaching acquisition criterion animals were injected with either substance P (1 ng/g) or vehicle. Different groups of mice were retrained on the same task either 1, 2, 3, or 7 days after original learning. Savings scores were calculated and, at every interval, substance P-treated mice retained the task better than control animals. One interpretation of these data is that substance P-treated mice remembered the original task significantly better than vehicle-injected control animals. 相似文献
43.
Fixation point digits have been widely used in tachistoscopic laterality studies as a simple and convenient means of ensuring unihemispheric projection of stimulus materials to the hemispheres. Previous findings demonstrate that fixation digits do not influence asymmetries in recognition accuracy studies with adult Ss. Present results, comparing four conditions differing in their use of fixation digits, show that in the naming latency paradigm the requirement to remember and report fixation control digits significantly augments RVF superiority. Implications for other latency tasks are discussed. 相似文献
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45.
A. H. C. van der Heijden R. Schreuder L. Maris M. Neerincx 《Attention, perception & psychophysics》1984,36(6):577-585
This study investigates the separate activation versus coactivation issue for redundant targets in a simple letter-detection paradigm with latency as the dependent variable. The results of a one-response visual-search task are reported. Since, on single-target trials, only the target was presented and no accompanying noise element, no “distraction decrement” caused by irrelevant noise elements (Grice et al., 1984) was to be expected. The data obtained showed a clear redundantsignal effect. Subsequent detailed analysis of the latency data using Miller’s (1982) procedure indicated that the results were consistent with a separate activation model and failed to provide convincing evidence in favor of coactivation models. A further analysis of the data indicated that, in the present study, the separate channels were negatively correlated for a range of fast RTs and positively correlated for intermediate and larger RTs. No evidence in favor of Grice et al.’s (1984) distraction-decrement hypothesis was found. The conclusions of this study are that (1) a separate activation model summarizes the essential features of information processing in this simple visual search task, and (2) no convincing evidence in favor of coactivation in visual search tasks has been reported in the literature up to now. 相似文献
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47.
The use of sacrificial animal blood in the Hebrew Bible has generated much discussion. While various scholars have attempted to explain the significance of these blood rites, each of these attempts has proved problematic. The current paper employs mimetic theory to develop a more robust and plausible model for exploring biblical animal sacrifice. Using the Passover ritual as a model, I develop a model of sacrificial blood rites as pantomimes of mimetic violence. These pantomimes re-create a violent yet transformative crisis from the community's collective memory. Such rituals allow the community to enter into and re-experience the cleansing violence of a mimetic crisis, albeit in a more controlled manner. Through these pantomimes, the community attempts to appease the primitive sacred's blood lust and re-discover the divine blessing secured through the original crisis. This model may prove helpful when applied to more opaque examples of biblical blood manipulation. 相似文献
48.
Yolanda van Beek David Hessen Lisa Levelt Daniëla Beijer Corine Rijnberk Athanasios Maras Mathilde M. Overbeek 《Journal of Family Therapy》2023,45(3):271-290
The effectiveness of intense specialised multi-family therapy (ISMFT) for 111 multi-stressed families, and the therapeutic alliance as a possible predictor of outcome, were examined. A repeated measures design was used, where changes in all ISMFT phases (preparation, multi-family therapy and follow-up) were assessed and compared for both mothers and fathers. Evidence was found for improved family functioning after the therapy period, which was maintained at 3 months follow-up, although the multi-stressed families still functioned in the problematic range. The therapy did however not decrease parenting stress, or did so only temporarily. Observations of the therapeutic alliance with the System for Observing Family Therapy Alliances (SOFTA) scales indicated that high therapist engagement was related to positive therapy outcomes, both at the start of therapy and later. High family engagement also predicted therapy effectiveness, but only at the start of therapy. The present study shows that solution-focused multi-family therapy at least seems to provide the first step in alleviating problems in multi-stressed families. 相似文献
49.
Linet R. Durmuşoğlu Sarah L. de Lange Theresa Kuhn Wouter van der Brug 《Political psychology》2023,44(3):583-601
Research shows that parents have a strong influence on the party preferences of their children. Yet little is known about how such preferences are transmitted in multiparty systems with weak party identification and high electoral volatility. We propose a model of intergenerational transmission that includes both direct effects of parents' party preferences on those of their children, as well as indirect effects through left–right and issue positions. We test this model with original survey data of Dutch adolescents (14–20 years old) and their parents (N = 751 adolescent-parent pairs). We find two paths through which parents exert influence on the party preferences of their adolescent children. On the first path, parental party preferences function as a direct predictor of adolescent party preferences. On the second path, adolescent left–right and issue positions function as a mediator between parental left–right and issue positions and adolescent party preferences, with the effect of left–right positions being stronger than that of issue positions. The frequency with which adolescents discuss political topics with their parents moderates these effects. 相似文献
50.
Marlene Meyer Johanna E. van Schaik Francesco Poli Sabine Hunnius 《Developmental science》2023,26(1):e13259
When teaching infants new actions, parents tend to modify their movements. Infants prefer these infant-directed actions (IDAs) over adult-directed actions and learn well from them. Yet, it remains unclear how parents’ action modulations capture infants’ attention. Typically, making movements larger than usual is thought to draw attention. Recent findings, however, suggest that parents might exploit movement variability to highlight actions. We hypothesized that variability in movement amplitude rather than higher amplitude is capturing infants’ attention during IDAs. Using EEG, we measured 15-month-olds’ brain activity while they were observing action demonstrations with normal, high, or variable amplitude movements. Infants’ theta power (4–5 Hz) in fronto-central channels was compared between conditions. Frontal theta was significantly higher, indicating stronger attentional engagement, in the variable compared to the other conditions. Computational modelling showed that infants’ frontal theta power was predicted best by how surprising each movement was. Thus, surprise induced by variability in movements rather than large movements alone engages infants’ attention during IDAs. Infants with higher theta power for variable movements were more likely to perform actions successfully and to explore objects novel in the context of the given goal. This highlights the brain mechanisms by which IDAs enhance infants’ attention, learning, and exploration. 相似文献