骨源性因子ucOCN在运动抗抑郁中的作用机制

羧化不全骨钙素(ucOCN)是骨中成骨细胞分泌的特异性蛋白,因其在调控神经发育、神经可塑性等中的重要角色而受到神经科学领域关注。"骨-脑"串联"对话"是骨内分泌-神经介导的应答系统,ucOCN透过血脑屏障后介导单胺类神经递质、神经内分泌、神经免疫、神经再生及基因表达等机制,进而作用于海马CA3区、扣带回等脑区功能发挥来调节抑郁发生及改善。而ucOCN作为骨源性力学刺激敏感基因,运动上调其表达后进入血液循环,通过介导5-HT/GABA分泌、HPA轴功能、炎症反应、神经营养因子(BDNF等)表达或信号途径(如GSK3β/β-catenin、TLR4/miR-223/NLRP3等)激活等来实现"骨串联脑",发挥运动抗抑郁作用。通过对骨源性因子ucOCN介导脑区功能变化从而实现运动抗抑郁的作用机制进行探讨、梳理,一方面有助于更深入了解骨内分泌功能,另一方面为抑郁发生、改善和运动抗抑郁研究提供新的理论基础和研究思路。     

当代心理学发展的一种新取向--进化心理学

进化心理学是近年在西方心理学中出现的一种新的研究取向,目前仍没有一个明确的概念和系统的理论。其基本主张是：过去是理解心理机制的关键;功能分析是理解心理机制的主要途径;心理机制是在解决问题的过程中演化形成的;模块性是心理机制整体组织的特性;人的行为是心理机制和环境互动作用的结果。进化心理学的发展既有意义同时也存在局限。其意义是：其发展与当代科学发展趋势相一致;它的研究促进了对人性和心理的进一步思考。局限是：具有遗传决定论的倾向;方法论存在一定的缺陷,忽视了文化对进化的意义等等。     

社会快感缺失认知过程的跨诊断研究进展

社会快感缺失具有广泛的跨诊断和亚临床特征,包括孤独感、内向性、社交焦虑和社会功能受损等。传统医学模型聚焦于社会快感缺失相关疾病的诊断和神经生理机制,促进了社会快感缺失药物和神经靶向治疗。然而社会快感缺失广泛地存在于健康人群和亚临床人群中,只有寻找有效的心理咨询和治疗方案,才会对亚临床人群社会快感缺失的缓解和社会功能的提升提供帮助。认知过程模型聚焦于积极效价系统,强调对积极奖赏刺激注意、记忆、心理意象等认知过程的提升,该模型将是社会快感缺失心理咨询与治疗的有效途径。

     

PROBABILITY DISCORDANCE AND CHOICE REACTION TIME: I. Effects of discordant probability on choice reaction time during prolonged training

Successive development of disinhibitory action over long monotonous training periods was studied with choice RT stimuli possessing discordant properties related to their relative frequency and the direction of movement. The results indicate that stimuli with strong initial proactive interference on ensuing reaction to the critical probe-stimulus become, with prolonged training, the least interfering.     

视觉注意捕获的快速脱离假说与信号抑制假说

快速脱离假说和信号抑制假说都是将传统的自下而上捕获和自上而下控制结合起来的混合模式假说。快速脱离假说认为突显干扰物总能在第一时间自下而上地捕获注意, 当突显干扰物与任务要求不符时, 注意会迅速脱离该位置。信号抑制假说认为突显干扰物都会产生“注意我”的信号, 当突显干扰物与任务要求不符时, 该信号会被自上而下地抑制以阻止注意捕获发生。前者相关的研究多采用空间线索提示范式和眼动脱离范式, 实验中被试采取独子探测策略, 而后者相关的研究多采用额外单例范式的变式, 实验中被试采取特征探测策略。未来研究应采用不同的刺激类型和实验方法进一步为两个假说提供证据支持, 同时要关注奖赏、训练等因素对“捕获-脱离”和“信号-抑制”的影响。     

Examining the item response process to personality measures in high-stakes situations: Issues of measurement validity and predictive validity

We conducted two experimental studies with between-subjects and within-subjects designs to investigate the item response process for personality measures administered in high- versus low-stakes situations. Apart from assessing measurement validity of the item response process, we examined predictive validity; that is, whether or not different response models entail differential selection outcomes. We found that ideal point response models fit slightly better than dominance response models across high- versus low-stakes situations in both studies. Additionally, fitting ideal point models to the data led to fewer items displaying differential item functioning compared to fitting dominance models. We also identified several items that functioned as intermediate items in both the faking and honest conditions when ideal point models were fitted, suggesting that ideal point model is “theoretically” more suitable across these contexts for personality inventories. However, the use of different response models (dominance vs. ideal point) did not have any substantial impact on the validity of personality measures in high-stakes situations, or the effectiveness of selection decisions such as mean performance or percent of fakers selected. These findings are significant in that although prior research supports the importance and use of ideal point models for measuring personality, we find that in the case of personality faking, though ideal point models seem to have slightly better measurement validity, the use of dominance models may be adequate with no loss to predictive validity.     

FOK判断等级及其准确性的实验研究

通过实验集中探讨了FOK判断等级及其准确性的影响因素。实验以中文字串为学习材料,使用组内设计的实验方法研究了被激活信息的量和强度对FOK等级及准确性的影响。实验结果表明：FOK判断的等级是由被激活信息的总量决定的,和被激活信息的正确与否无关;FOK判断的准确性是由被激活信息的强度决定的;且二者之间是有内在联系的。     

试析学校体育对青少年社会性格的影响

社会性格是指在一定社会结构中的大多数人为了适应社会条件的需要而共同具有的稳定的心理特征倾向及其行为习惯方式。学校体育运动可以为人们提供多种活动情景,对参与者或观看者产生一定的影响,为培养良好的社会性格创造有利的条件。     

Bird on Dispositions and Antidotes

In The Philosophical Quarterly , 48 (1998), Alexander Bird raises an objection against the conditional analysis of dispositions: where an 'antidote' is present all the supposed conditions for manifestation of a disposition are fulfilled but the manifestation does not occur. But Bird's argument suffers from equivocation. If we spell out properly whether the disposition's conditions are to include the presence of the antidote or not, the apparent counter-examples disappear. So his examples do not undermine the conditional analysis of dispositions; they show merely that we need to be careful about describing the examples consistently.