蛋白质相互作用研究的哲学思考

蛋白质相互作用几乎是所有生物学过程都必需的重要的生理过程,已成为国内外生命科学研究的热点之一.近十年来,多个诺贝尔生理医学奖项目与蛋白质相互作用研究有关.从蛋白质相互作用的特点和重要性出发,结合我们实践中的点滴体会,列举有关实例与数据说明:为什么蛋白质相互作用研究是细胞通讯网络途径中的重要研究环节,从而提出:蛋白质与蛋白质相互作用研究具有丰富的哲学内涵.     

可旋转地图和固定地图的定位效率研究

本研究采用两个分实验,分别比较了在空白背景与复杂背景上地图旋转与地图固定两种导航方式下被试的方位判断反应时之间的差异,然后考察两种背景在两种导航方式差异上的一致性问题。结果发现,在运动点的运动方向为朝上、朝左和朝右时,对于空白背景,地图旋转方式下的反应时显著低于地图固定方式;而对于复杂背景,两种导航方式下的反应时之间不存在显著差异。在运动点的运动方向为朝下时,对于两种背景,地图旋转方式的反应时均显著低于地图固定方式。这一结果基本证实了本研究的假设,即被试利用地图进行空间定向的认知过程包括心理旋转与目标搜索两个阶段。     

评王其亨教授威尼斯看"风水"

《新京报》“文化新闻”6月5日载《中国学者为威尼斯看风水》。文中说道,将于6月9日开幕的“威尼斯国际艺术双年展”为国际艺术界所注目,而“以研究中国传统风水和地理环境著称”的天津大学教授王其亨,“这次转变身份为参展艺术家”。他“运用风水学分析之后”,制作出参展作品《威尼斯双年展的风水》。据王教授的研究:“大运河穿过威尼斯城形成的图形恰似太极,而双年展国家馆部分中,美国馆风水甚好,而日本、巴西则颇有缺失。如此富有中国传统特色的分析想比会让很多人发生好奇”。该新闻同时刊载了王教授分析威尼斯风水后所作的“运河在城内…     

汉语发展性深层阅读障碍的个案研究

报告了一个发展性阅读障碍个案J,J的语音技能存在缺陷,音位、声调意识差,语音短时记忆能力弱,在汉字命名中产生大量语义错误、视觉错误和选择错误,表现出一系列深层阅读障碍症候群,是一例典型的深层阅读障碍个案。还讨论了汉语发展性阅读障碍亚类型的分类标准以及分布特点。     

Changes in suicide methods in Quebec between 1987 and 2000: the possible impact of bill C-17 requiring safe storage of firearms

This study presents the changes in the overall and firearm suicide rates for Québec (Canada) before and after Bill C-17, which was implemented to secure safe storage of firearms. It covers 20,009 suicide cases reported to the coroner's office. Interrupted time series analysis is used to compare suicide rates in the two periods. Firearm suicide rates have dropped among males and females, but the downward trends were not significant when compared to those prior to the law. Hanging suicide rates have risen considerably among men and women, but those upward trends did not increase significantly when compared with those preceding the law. The decline in suicide rates involving firearms has not resulted in a parallel decline in overall suicide rates. The analyses suggest that Bill C-17 neither improved the downward trend in firearm suicide, which had already begun before the enactment of the law, nor reduced the upward trend of the overall suicide rate. Correlation analyses between firearm suicide, hanging suicide, and the overall suicide rate suggest that firearm suicide is replaced by hanging suicide among males.     

言语中的音高信息声学语音学加工的大脑偏侧化

旨在探讨言语中音高信息自下而上的声学语音学加工的神经机制和大脑偏侧化.发现,被动听和主动判断任务分别激活了颞叶和额叶,激活在颞极、颞上回和额下回眶部表现出明显的右侧优势.结果表明,对言语中音高信息自下而上的声学语音学加工主要是右脑的功能,言语与非言语信号的音高信息可能有相似的加工机制,支持Gandour等提出的理论.     

Early vocabulary inventory for Mandarin Chinese

Early vocabulary development is a reliable predictor of children's later language skills. The MacArthur-Bates Communicative Development Inventory (CDI) has provided a powerful tool to assess earlyvocabulary development in English and other languages. However, there have been no published CDI norms for Mandarin Chinese. Given the importance of large-scale comparative data sets for understanding the early childhood lexicon, we have developed an early vocabulary inventory for Mandarin. In this article, we report our efforts in developing this instrument, and discuss the data collected from 884 Chinese families in Beijing over a period of 12-30 months, based on our instrument. Chinese children's receptive and expressive lexicons as assessed by our inventory match well with those reported for English on the basis of CDI. In particular, our data indicate comprehension-production differences, individual differences in early comprehension and in later production, and different lexical development profiles among infants versus toddlers. We also make the checklists and norms of our inventory available to the research community via the Internet; they may be accessed from the Psychonomic Society's Archive of Norms, Stimuli, and Data, at www.psychonomic.org/archive.     

社会认知神经科学研究的最新进展

社会认知神经科学是一门采用认知神经科学技术研究社会认知现象的交叉学科,目前已经形成认知神经科学与心理生理学的热点研究领域。该文回顾了近年来有关情绪、情绪障碍、自我意识、经济决策、道德等方面的脑机制研究,临床研究和脑成像研究表明,恐惧、厌恶、愤怒、惊讶、快乐、悲伤等基本情绪在表达和识别上具有普遍性与特殊性;孤独症与“男性脑”的特征相关,抗抑郁药百忧解对抑郁症儿童的治疗作用;在自我意识的研究领域,自我概念产生的脑区定位、灵长类的自我意象、精神疾病患者的自我概念变化等研究的热点问题;经济决策的研究最近成为亮点之一,主要包括强互惠合作、风险决策、跨期选择以及品牌决策等方面;在道德的脑机制研究中,重点涉及了道德判断与捐赠行为的神经基础。文章最后展望了社会认知神经科学在我国发展的前景     

不同阅读水平儿童中央执行系统比较研究

本研究通过两部分实验探讨汉语发展性阅读障碍儿童与正常儿童中央执行系统的容量差异和这种差异的性质。通过比较匹配生理年龄的不同阅读水平儿童在自定步速和固定步速的复杂阅读广度测验中的成绩,发现发展性阅读障碍儿童在两种阅读广度测验中都表现出中央执行系统容量的缺陷,这种缺陷既不能用加工效率理论,也不能用资源分配理论来解释,而符合一般容量假设。因此,本研究支持发展性阅读障碍儿童存在实时加工和存储信息的一般容量缺陷。     

Speech perception deficits by Chinese children with phonological dyslexia

Findings concerning the relation between dyslexia and speech perception deficits are inconsistent in the literature. This study examined the relation in Chinese children using a more homogeneous sample—children with phonological dyslexia. Two experimental tasks were administered to a group of Chinese children with phonological dyslexia, a group of age-matched control children, and a group of adults. In addition to a categorical perception task, a selective adaptation task was carried out. The results indicated that Chinese children with phonological dyslexia were less consistent than both the child and adult control groups in identifying stimuli within a given phonetic category. Furthermore, they did not show any significant adaptation effects in the selective adaptation task even when the adapting stimulus was identical to an endpoint stimulus in the test continuum. It seems that children with phonological dyslexia have a general deficiency in representing and processing speech stimuli.