Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Comparative clinicogenetic study of schizophrenic psychoses

The author diagnoses 350 carefully selected schizophrenic subjects, their parents and their siblings during parallel studies using three different clinical classification systems and analyzes the results by multiple threshold analysis and the multifactorial inheritance model. The results suggest that, of the three classifications the author studied, Leonhard's and Sneshnewski's system yield relatively homogeneous subgroups; this indicates the future significance of these nosological systems for the planning of biopsychiatric research.     

Compliance with homework to employ self-instructions in controlling ice water pain: an analogue to counseling

40 women were taught to use self-statements to cope with pain caused by ice water. The trainer used four different strategies for reassigning a homework task of using self-statements to cope with pain produced by immersing one hand in ice water. The strategies were equally effective in eliciting compliance with the homework assignment.     

The horizontal-vertical illusion in photographs of concrete scenes with and without depth information

On the basis of the hypothesis of misapplied constancy scaling, the perception of an abstract horizontal-vertical illusion figure embedded in photographs of natural scenes with depth cues is investigated. The effect is compared with that of a figure on photographs containing no depth information and with a figure on a neutral surface. It is shown that the magnitude of the illusion in the perspective scenes is greater than in the other two conditions. The results are considered compatible with a constancy theory of the illusion. Finally, the evidence for misapplied constancy scaling in the horizontal-vertical illusion in relation to a retinal theory is discussed.     

Auditory-successive selective attention for learning disabled and normal boys

Improvement in auditory-successive selective attention was noted across the age range of 9 through 16 yr. In contrast to comparable paradigms with visual-simultaneous materials, 30 learning disabled and 30 normal boys did not differ. Results of research on selective attention may be affected by task materials and encoding requirements.     

Psychometric studies on the specificity of psychological performance disorders of epileptic patients

Using a psychological test battery for registration of psychic/psychomotoric speed and flexibility/perseveration we examined 78 epileptic patients with different forms of epilepsy and the same number of brain healthy control persons, parallelised in sex, age, education, profession and intelligence. The registrated data were varianz-, correlation- and factoranalised. We found a deceleration of psychic/psychomotoric speed as a primary basic disorder in epileptics. Decreases of flexibility independent of speed were not ascertainable.     

Temporal proximity and reinforcement sensitivity in multiple schedules

Distributions of reinforcers between two components of multiple variable-interval schedules were varied over a number of conditions. Sensitivity to reinforcement, measured by the exponent of the power function relating ratios of responses in the two components to ratios of reinforcers obtained in the components, did not differ between conditions with 15-s or 60-s component durations. The failure to demonstrate the “short-component effect,” where sensitivity is high for short components, was consistent with reanalysis of previous data. With 60-s components, sensitivity to reinforcement decreased systematically with time since component alternation, and was higher in the first 15-s subinterval of the 60-s component than for the component whose total duration was 15 s. Varying component duration and sampling behavior at different times since component transition may not be equivalent ways of examining the effects of average temporal distance between components.     

Representation and retention of three-event sequences in pigeons

The present experiments studied a three-event delayed sequence-discrimination (DSD) task: one arrangement (order) of two stimuli (red and yellow overhead lights) taken three in succession (e.g., red, yellow, red) was the positive sequence and the remaining seven arrangements were the negative sequences for responding and reward during the subsequent test stimulus. In Experiment 1, the final stimulus (recency) and the order of stimuli in the positive sequence controlled acquisition of discrimination. In Experiment 2, increasing the duration of memory intervals between stimuli reduced the discriminability of those negative sequences identical to the positive sequence after the delay. Three-event DSD performance in Experiments 1 and 2 was similar to two-event DSD performance in comparable published experiments. Models developed to explain pigeon performance in two-event DSD were extended to the three-event task. Results from both two- and three-event versions of the DSD task falsified a noncumulative model and several cumulative integration models (i.e., adding, averging, and some multiplying models), but corroborated one cumulative, multiplying model.     

Biomagnetism from the neuropsychiatric viewpoint--principles of recent developments in diagnostic procedure

The following survey is intended to demonstrate and discuss some principle problems of biomagnetism and the application in clinical fields. The development of special technical parameters especially by the SQUID method is initiating new possibilities of research and completing the neurobiologically determinated basis and conditions of neuropsychiatric disorders. The Magnetoencephalography (MEG) will be represent an important role of a new functional diagnostic method.